2. Epigenetics PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. AMPK FLT3 Src VEGFR Ephrin Receptor MNK Ribosomal S6 Kinase (RSK)
  4. Multi-kinase-IN-12

Multi-kinase-IN-12 是一种非选择性的多靶点抑制剂，对人源靶点的 IC50 值分别为：Flt3 < 0.001 μM、c-Src 0.002 μM、KDR 0.004 μM、Eph-A2、MNK-1 与 Flt1 0.011 μM、Lck 0.016 μM、Rsk1 0.21 μM、AMPK α2 亚基 0.041 μM。Multi-kinase-IN-12 可用于实体瘤的相关研究。

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Multi-kinase-IN-12

Multi-kinase-IN-12 Chemical Structure

CAS No. : 597544-21-3

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Multi-kinase-IN-12 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

查看所有亚型
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

查看 Src 亚型特异性产品:

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 Ephrin Receptor 亚型特异性产品:

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EphB EphA

查看 MNK 亚型特异性产品:

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MNK1 MNK2 MNK

查看 Ribosomal S6 Kinase (RSK) 亚型特异性产品:

查看所有亚型
p70S6K RSK2 RSK3 RSK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-kinase-IN-12 is a non-selective multi-target inhibitor, with IC50 values against human targets as follows: Flt3 < 0.001 μM, c-Src 0.002 μM, KDR 0.004 μM, Eph-A2, MNK-1 and Flt1 0.011 μM, Lck 0.016 μM, Rsk1 0.21 μM, and α2 subunit of AMPK 0.041 μM. Multi-kinase-IN-12 can be used in research related to solid tumors[1].

体外研究
(In Vitro)

Multi-kinase-IN-12 可强效抑制重组人源 AMPK α2/β1/γ1 异源三聚体，其 IC50 为 0.04 μM[1]。
Multi-kinase-IN-12 (1-10 μM; 6 h) 可抑制 MEF 细胞中的细胞 AMPK 活性 (通过 ACC 磷酸化水平检测)，在 10 μM 处理 6 小时时可观察到显著抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Multi-kinase-IN-12 相关抗体:

Western Blot Analysis[1]

Cell Line: Mouse embryonic fibroblast (MEF) cells
Concentration: 1, 5 and 10 μM
Incubation Time: 6 h
Result: Reduced ACC phosphorylation to ~1.2-fold of untreated control at 1 μM.
Reduced ACC phosphorylation to ~1.1-fold of untreated control at 5 μM.
Significantly reduced ACC phosphorylation to ~0.5-fold of untreated control at 10 μM.
分子量

401.47

Formula

C23H23N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-kinase-IN-12 相关分类

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Keywords:

Multi-kinase-IN-12597544-21-3AMPKFLT3SrcVEGFREphrin ReceptorMNKRibosomal S6 Kinase (RSK)AMP-activated protein kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Vascular endothelial growth factor receptorMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseS6KFlt3AMPK α2 subunitKDRLckc-SrcEph-A2Rsk1acetyl CoA carboxylase 1MNK-1Flt1Inhibitorinhibitorinhibit

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