2. Apoptosis
  3. Survivin
  4. MX106

MX106 是一种 survivin 抑制剂，也是 UC-112 (HY-12842) 的类似物。MX106 可在体外和体内抑制 survivin 的表达。MX106 抑制人黑色素瘤细胞、表皮样癌细胞和结肠癌细胞的增殖，对过表达 P-糖蛋白的多药耐药细胞系也有抑制作用。

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MX106

MX106 Chemical Structure

CAS No. : 2170836-81-2

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MX106 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MX106 is a survivin inhibitor and an analog of UC-112 (HY-12842). MX106 inhibits the expression of survivin both in vitro and in vivo. MX106 suppresses the proliferation of human melanoma cells, epidermoid carcinoma cells and colon cancer cells, and also exerts inhibitory effects on multidrug-resistant cell lines overexpressing P-glycoprotein[1].

体外研究
(In Vitro)

MX106 (0.03 nM-1 μM; 72 h) 可抑制人黑色素瘤细胞、表皮样癌细胞和结肠癌细胞的增殖，对过表达 P-糖蛋白的多药耐药细胞系的抑制活性更强，对 SW620/Ad300 细胞的 IC50 低至 0.03 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MX106 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A375, WM164, M14, M14/MDR1, KB-3-1, KB-C2, SW620, SW620/Ad300
Concentration: 0.03 nM-1 μM; 0.9 μM (A375); 1.1 μM (WM164); 0.8 μM (M14); 1.8 μM (M14/MDR1); 1.25 μM (KB-3-1); 0.33 μM (KB-C2); 0.15 μM (SW620); 0.03 μM (SW620/Ad300)
Incubation Time: 72 h
Result: Inhibited proliferation of A375 cells with an IC50 of 0.9 ± 0.1 μM.
Inhibited proliferation of WM164 cells with an IC50 of 1.1 ± 0.2 μM.
Inhibited proliferation of M14 cells with an IC50 of 0.8 ± 0.2 μM.
Inhibited proliferation of M14/MDR1 cells with an IC50 of 1.8 ± 0.4 μM, showing 2.3-fold resistance compared to parental M14 cells.
Inhibited proliferation of KB-3-1 cells with an IC50 of 1.25 ± 0.10 μM.
Inhibited proliferation of KB-C2 cells with an IC50 of 0.33 ± 0.12 μM, showing 3.8-fold greater potency compared to parental KB-3-1 cells.
Inhibited proliferation of SW620 cells with an IC50 of 0.15 ± 0.01 μM.
Inhibited proliferation of SW620/Ad300 cells with an IC50 of 0.03 ± 0.01 μM, showing 5-fold greater potency compared to parental SW620 cells.
分子量

390.53

Formula

C25H30N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MX106 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MX1062170836-81-2MX 106MX-106Survivinepidermoid carcinoma cellsmultidrug-resistant cell linessurvivinP-glycoproteinSW620/Ad300 cellshuman melanoma cellscolon cancer cellsInhibitorinhibitorinhibit

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