2. Metabolic Enzyme/Protease
  3. NAMPT E1/E2/E3 Enzyme
  4. NAMPT activator-9

NAMPT activator-9 (Compound DIPM) 是一种变构、非竞争性 NAMPT 激活剂，对 hNAMPT 的 EC50 为 3.366 μM。NAMPT activator-9 通过变构、非竞争性机制增强 NAMPT 的酶活性。NAMPT activator-9 可提升细胞内 NAD+ 水平。NAMPT activator-9 可恢复肌管直径，降低萎缩标志物 Atrogin-1 和 MuRF1 的表达。NAMPT activator-9 可用于肌肉萎缩的相关研究。

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NAMPT activator-9

NAMPT activator-9 Chemical Structure

CAS No. : 931366-46-0

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NAMPT activator-9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NAMPT activator-9 (Compound DIPM) is an allosteric, non-competitive NAMPT activator, with an EC50 of 3.366 μM against hNAMPT. NAMPT activator-9 enhances the enzymatic activity of NAMPT via an allosteric, non-competitive mechanism. NAMPT activator-9 increases intracellular NAD+ levels. NAMPT activator-9 restores myotube diameter and reduces the expression of atrophy markers Atrogin-1 and MuRF1. NAMPT activator-9 is applicable to research related to muscle atrophy[1].

体外研究
(In Vitro)

NAMPT activator-9 (60 min) 是 hNAMPT 的强效变构激活剂，其 EC50 为 3.366 μM[1]。
NAMPT activator-9 (0.741-20 μM; 24 h) 可显著升高完全分化的 C2C12 肌管内的细胞内 NAD+水平及 NAD+/NADH 比值；在 2.222 μM 处理 24 h 后，NAD+ 水平升高约 2 倍[1]。
NAMPT activator-9 (2.222-20 μM; 24 h) 可通过降低萎缩标志物的表达，保护完全分化的 C2C12 肌管免受 Dexamethasone (HY-14648) 诱导的萎缩[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NAMPT activator-9 相关抗体:

Cell Viability Assay[1]

Cell Line: Fully differentiated C2C12 myotubes
Concentration: 0.247-4860 μM
Incubation Time: 24 h
Result: Showed no obvious toxicity in C2C12 myotubes up to 180 μM, with an IC50 value of 1.98 mM.

Western Blot Analysis[1]

Cell Line: Fully differentiated C2C12 myotubes (dexamethasone-induced atrophy model)
Concentration: 2.222-20 μM (co-incubated with 10 μM dexamethasone)
Incubation Time: 24 h
Result: Nearly completely abolished Dexamethasone-induced upregulation of Atrogin-1 and MuRF1 expression.
Reversed dexamethasone-induced reduction of MyHC expression, with significant recovery at all tested concentrations.
分子量

305.33

Formula

C17H15N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NAMPT activator-9 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAMPT activator-9931366-46-0NAMPT activator9NAMPT activator 9NAMPTE1/E2/E3 EnzymeNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseSER-275ASP-219muscle atrophyC2C12 myotubesNAD+MuRF1Atrogin-1myosin heavy chainVAL-242Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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