2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. NCX-278

NCX-278 是一种人类碳酸酐酶 (carbonic anhydrase) 抑制剂，对 hCA II 的 Ki 为 13 nM，对 hCA I 的 Ki 为 410 nM，对 hCA IV 的 Ki 为 181 nM，且对 hCA II 的抑制作用相较于 hCA IV 具有选择性。NCX-278 是一种强效的 NO/sGC/cGMP 信号刺激剂，其 EC50 为 2.05 μM。NCX-278 可发挥 NO 介导的血管舒张作用。NCX-278 能够降低正常血压兔的眼内压。NCX-278 可用于开角型青光眼的研究。

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NCX-278

NCX-278 Chemical Structure

CAS No. : 1202697-61-7

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NCX-278 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NCX-278 is a human carbonic anhydrase inhibitor with a 13 nM Ki for hCA II, 410 nM Ki for hCA I, 181 nM Ki for hCA IV, and selective inhibition of hCA II over hCA IV. NCX-278 is a potent and effective stimulator of NO/sGC/cGMP signaling with an EC50 of 2.05 lM. NCX-278 exerts NO-mediated vascular relaxant effects. NCX-278 lowers intraocular pressure in normotensive rabbits. NCX-278 can be used for the research of open-angle glaucoma[1].

IC50 & Target

hCA II

13 nM (Ki)

hCA I

410 nM (Ki)

体外研究
(In Vitro)

NCX-278 可强效抑制重组人源 hCA II，其 Ki 值为 13 nM；对 hCA II 的选择性是 hCA IV 的 13.9 倍，同时抑制 hCA I 的 Ki 值为 410 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCX-278 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Tmax
Rat[1] 55 mM o.a. 120 min
体内研究
(In Vivo)

NCX-278 (55 mM；眼部给药；单次给药) 可使正常血压新西兰白兔的眼内压产生具有统计学意义的最大降幅 (-3.7 mmHg)，给药后 120 分钟达到作用峰值[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand white rabbits[1]
Dosage: 55 mM
Administration: o.a.; single dose
Result: Reduced intraocular pressure to a maximal effect of -3.7 mmHg.
Reached peak effect at 120 minutes post-dosing.
Returned to basal intraocular pressure levels at 360 minutes post-dosing.
分子量

471.53

Formula

C14H21N3O9S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NCX-278 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCX-2781202697-61-7NCX278NCX 278Carbonic AnhydraseCarbonate dehydrataserecombinant human hCA IIopen-angle glaucomavascular relaxant effectshCA IVhuman carbonic anhydraseintraocular pressurenormotensive rabbitshCA IhCA IINew Zealand white rabbitsInhibitorinhibitorinhibit

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产品名称：
NCX-278
目录号：
HY-182426
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