2. Membrane Transporter/Ion Channel
  3. ASCT
  4. P-LPK

P-LPK 是一种特异性靶向结直肠癌细胞膜上高表达的 SLC1A5 的十二肽，其 Kd 值为 1.19 μM。P-LPK 不具备固有细胞增殖调控活性。经镓-68 标记的 P-LPK 可在异种移植小鼠模型中选择性聚集于结直肠癌肿瘤部位。P-LPK 可作为靶向载体将 Camptothecin (HY-16560) 递送至结直肠癌细胞，形成偶联物 P-LPK-CPT。P-LPK 可用于结直肠癌的研究。

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Custom Peptide Synthesis

P-LPK

P-LPK Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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P-LPK 相关抗体

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ASCT2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P-LPK is a dodecapeptide that specifically targets SLC1A5, which is highly expressed on the membrane of colorectal cancer cells, with a Kd value of 1.19 μM. P-LPK has no intrinsic cell proliferation regulatory activity. Gallium-68-labeled P-LPK selectively accumulates at colorectal cancer tumor sites in xenograft mouse models. P-LPK can serve as a targeted carrier to deliver Camptothecin (HY-16560) to colorectal cancer cells, forming the conjugate P-LPK-CPT. P-LPK can be used in the research of colorectal cancer[1].

体外研究
(In Vitro)

P-LPK (2 小时) 可选择性结合人结直肠癌细胞系 Colo320HSR、HCT116 和 LoVo 的细胞膜，其结合能力显著高于未转化的人结肠上皮细胞 NCM460[1]。
P-LPK 可选择性结合人结直肠癌 (CRC) 组织，其结合能力显著高于对人癌旁正常结肠组织的结合能力[1]。
P-LPK (过夜) 在人结直肠癌 HCT116 细胞的细胞膜上与 SLC1A5 共定位，而 P-LPK 的突变会破坏这种结合[1]。
P-LPK (24-72 h) 对人结直肠癌 HCT116 细胞、LoVo 细胞以及未转化的人结肠上皮 NCM460 细胞均无细胞毒性或增殖调控作用[1]。
P-LPK 主要通过网格蛋白介导的内吞机制被内化至人结直肠癌 HCT116 细胞中[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

P-LPK 相关抗体:
体内研究
(In Vivo)

68Ga-P-LPK (3.7 MBq；静脉注射；单次给药) 可在裸鼠的 HCT116 结直肠肿瘤中选择性聚集，其结合作用可被未标记的 P-LPK (静脉注射；预注射) 竞争性抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (female, 4 weeks old)[1]
Dosage: 3.7 MBq (100 μCi, 0.1 nmol in 100 μl) (68Ga-P-LPK); unlabeled P-LPK (blocking experiment)
Administration: i.v.; single dose; pre-injection (blocking experiment)
Result: Showed remarkable accumulation in HCT116 tumors at all time points, with significantly higher tumor/non-tumor (T/NT) ratios compared to 68Ga-P-CON.
Demonstrated no significant accumulation in U87 tumors.
Dramatically attenuated 68Ga-P-LPK binding to HCT116 tumors when pre-injected as unlabeled P-LPK, significantly reducing T/NT ratios at 60 and 120 minutes.
分子量

1291.47

Formula

C54H94N14O20S
Sequence

Leu-Pro-Lys-Thr-Val-Ser-Ser-Asp-Met-Ser-Leu-Asn
Sequence Shortening

LPKTVSSDMSLN
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P-LPK 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-LPKASCTAlanine Serine Cysteine TransportersSLC1A5camptothecinglioblastoma cellscolorectal cancer cellshuman colorectal cancer cell linesxenograft mouse modelsSolute carrier 1 family member 5clathrin-mediated endocytosisnon-transformed colonic epithelial cellscolorectal cancerInhibitorinhibitorinhibit

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