2. Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. Pyruvate Kinase STAT Apoptosis
  4. PKM2 activator 11

PKM2 activator 11 (Compound 23) 是一种 PKM2 激活剂，其 AC50 值为 92.12 nM。PKM2 activator 11 可促进 PKM2 四聚化并抑制其核转位。PKM2 activator 11 可抑制糖酵解和 PKM2/STAT3 信号通路。PKM2 activator 11 可诱导细胞凋亡 (Apoptosis)。PKM2 activator 11 在体外对结直肠癌具有高效且选择性的抗癌活性。

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PKM2 activator 11

PKM2 activator 11 Chemical Structure

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PKM2 activator 11 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PKM2 activator 11 (Compound 23) is a PKM2 activator with an AC50 value of 92.12 nM. PKM2 activator 11 promotes PKM2 tetramerization and inhibits its nuclear translocation. PKM2 activator 11 suppresses glycolysis and the PKM2/STAT3 signaling pathway. PKM2 activator 11 induces Apoptosis. PKM2 activator 11 exhibits anti-CRC activity in vitro with potency and selectivity[1].

IC50 & Target[1]

STAT3

 

PKM2

 

分子量

457.54

Formula

C27H23NO4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PKM2 activator 11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKM2 activator 11Pyruvate KinaseSTATApoptosisanti-CRCInhibitorinhibitorinhibit

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