2. Anti-infection Apoptosis NF-κB Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. Bacterial Apoptosis Keap1-Nrf2 NF-κB Aryl Hydrocarbon Receptor STAT
  4. Plumericin

Plumericin 是一种抗炎、抗氧化、抗菌 (antibacterial) 剂。Plumericin 可减少细胞凋亡 (Apoptosis)，促进 Nrf-2 的表达并抑制 NF-κB 与 AhR 的激活，阻断 STAT3 信号通路。Plumericin 可抑制结核分枝杆菌 (Mycobacterium tuberculosis)的生长。Plumericin 可用于慢性肾脏病、血管疾病、炎症性肠病、腹膜炎及结核病的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Plumericin

Plumericin Chemical Structure

CAS No. : 77-16-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Plumericin 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Plumericin is an anti-inflammatory, antioxidant, and antibacterial agent. Plumericin reduces Apoptosis, promotes Nrf-2 and inhibits NF-κB and AhR activation, blocks STAT3 signaling. Plumericin inhibits Mycobacterium tuberculosis growth. Plumericin can be used for the research of chronic kidney disease, vascular diseases, inflammatory bowel diseases, peritonitis, and tuberculosis[1][2][3][4][5][6].

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

Plumericin (0.5-2 μM; 1 h) 可显著降低 IS 诱导的 IEC-6 细胞凋亡[1]。
Plumericin (0.5-2 μM; 1 h) 可显著抑制 IS 诱导的 IEC-6 细胞中 iNOS、COX-2 和 caspase-1 的表达，以及 IL-1β 的产生[1]。
Plumericin (0.3-3 μM; 30 min) 可抑制血清诱导的原代大鼠主动脉血管平滑肌细胞 (VSMC) 增殖[2]。
Plumericin (0.5-2 μM; 24 h) 不会降低大鼠肠上皮 IEC-6 细胞的增殖能力[3]。
Plumericin (30 min) 可强效抑制 HEK293/NF-κB-luc 细胞中 TNF-α 诱导的 NF-κB 激活， IC50 为 1.07 μM[4]。
Plumericin (0.5-2 μM; 24 h) 可显著提高经 LPS + IFN 刺激的 IEC-6 细胞的迁移速度，促进肠上皮损伤修复[5]。
Plumericin (MIC 为 5 天，MBC 为 6 周) 可抑制泛敏感结核分枝杆菌 H37Rv 的生长，其 MIC 为 2.1 ± 0.12 μg/mL；MBC 为 3.6 ± 0.22 μg/mL [6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Plumericin 相关抗体:

Apoptosis Analysis[1]

Cell Line: IEC-6 rat intestinal epithelial cells
Concentration: 0.5-2 μM
Incubation Time: 1 h pre-incubation, then 24 h co-incubation with IS
Result: Significantly reduced IS-induced apoptosis at all tested concentrations.
Significantly decreased pro-apoptotic Bax expression at all tested concentrations compared to IS-only treated cells.
Significantly increased anti-apoptotic Bcl-2 expression at all tested concentrations compared to IS-only treated cells.

Immunofluorescence[1]

Cell Line: IEC-6 rat intestinal epithelial cells
Concentration: 1 μM
Incubation Time: 1 h before IS
Result: Significantly reduced IS-induced nuclear translocation of NF-κB p65, decreasing nuclear NF-κB p65 fluorescence intensity compared to IS-only treated cells.
体内研究
(In Vivo)

Plumericin (3 mg/kg；腹腔注射；每日一次；4 天) 对经 DNBS (HY-W324435) 诱导结肠炎的雄性 CD1 小鼠发挥强效抗炎与抗氧化活性[3]。
Plumericin (3 mg/kg；腹腔注射；两次) 可在统计学上显著减少 Thioglycollate 诱导的中性粒细胞向小鼠腹膜的募集 (P < 0.001)[4]。
Plumericin (3 mg/kg；腹腔注射；每日一次；4 天) 可显著减轻 DNBS 诱导的小鼠结肠炎模型中的结肠炎症、PARP 活化及凋亡损伤[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice (male, 20-25 g, DNBS-induced colitis)[3]
Dosage: 3 mg/kg
Administration: i.p.; daily; 4 days
Result: Significantly reduced body weight loss compared to DNBS-only mice.
Prevented colon shortening relative to DNBS-only mice.
Significantly reduced macroscopic colon damage scores.
Reduced histological signs of colon injury, including decreased cellular infiltration, edema, and inflammatory lesions.
Significantly reduced colon TNF-α levels (P < .001 vs DNBS group).
Inhibited DNBS-induced IκB-α degradation and NF-κB p65 nuclear translocation.
Significantly reduced colon malondialdehyde (MDA) levels (P < .001 vs DNBS group).
Reduced nitrotyrosine immunoreactivity in colon tissue (P < .001 vs DNBS group).
Significantly increased colon Nrf2 and superoxide dismutase (SOD) expression.
Significantly reduced colon IL-1β levels (P < .001 vs DNBS group).
Reduced colon caspase-1 expression.
分子量

290.27

Formula

C15H14O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Plumericin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Plumericin77-16-7BacterialApoptosisKeap1-Nrf2NF-κBAryl Hydrocarbon ReceptorSTATNuclear factor-κBNuclear factor-kappaBAhRprimary rat aortic VSMCchronic kidney diseaseIKK-βIKK complexSTAT3Mycobacterium tuberculosisNrf2IEC-6 cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Plumericin
目录号：
HY-N16435
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z