2. Apoptosis
  3. Apoptosis
  4. PP-60

PP-60 是一种凋亡 (apoptosis) 诱导剂。PP-60 可抑制癌细胞增殖以及诱导癌细胞凋亡。PP-60 可在裸鼠肝肿瘤模型中发挥抗肿瘤作用。PP-60 可用于肝癌、肺癌、前列腺癌等癌症的相关研究。

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Custom Peptide Synthesis

PP-60

PP-60 Chemical Structure

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PP-60 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PP-60 is an apoptosis inducer. PP-60 inhibits the proliferation of cancer cells and induces cancer cell apoptosis. PP-60 exerts anti-tumor effects in nude mouse liver tumor models. PP-60 is applicable to research related to cancers such as liver cancer, lung cancer, and prostate cancer[1].

体外研究
(In Vitro)

PP-60 (24 h) 对 HepG2、A549 和 PC-3 细胞表现出强效抗增殖活性， IC50 值分别为 1.73，2.15, 2.69 μM[1]。
PP-60 (2 μM；2-4 h) 具有优异的细胞摄取能力[1]。
PP-60 (0-5 μM) 在 HepG2 细胞中剂量依赖的抑制细胞周期在 G2 期的进程, 当浓度为 5μM 时，处于 G2 期的细胞百分比达到约 35%[1]。
PP-60 (0-5 μM, 6 h) 在 HepG2 细胞中诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PP-60 相关抗体:

Immunofluorescence[1]

Cell Line: HepG2 cells
Concentration: 2 μM
Incubation Time: 2, 4 h
Result: Increased FITC fluorescence signal intensity indicates a stronger cellular uptake capacity.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 0, 1, 2, 5 μM
Incubation Time: 6 h
Result: Induced apoptosis, at a concentration of 5 μM, the apoptosis rate is approximately 80%.
体内研究
(In Vivo)

PP-60 (每只小鼠 0.5 mg；瘤内注射；于第 1、6、15 天给药) 在 HepG2 异种移植裸鼠模型中展现出强效抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (female; HepG2 (2 × 106 cells/mouse) xenograft model)[1]
Dosage: 0.5 mg per mouse
Administration: intratumoral injection; on day 1, 6, and 15
Result: Exhibited potent antitumor activity.
Reduced tumor volume; decreased tumor weight; showed the highest caspase 3 positive staining; reduced Ki67 positive cells to the lowest level; induced significant tumor cell apoptosis.
分子量

3103.74

Formula

C142H252N36O40
Sequence

Ac-{Arg(β-Glu(1→4)-α-Glu)}-Leu-{(S)-2-(4-pentenyl)alanine}-Lys-Asp-Lys-{(S)-2-(4-pentenyl)alanine}-Lys-Gly-Ile-Gly-Lys-Leu-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-{(S)-2-(4-pentenyl)alanine}--Lys-Thr-Leu-{(S)-2-(4-pentenyl)alanine}-NH2 (RCM bridge: {S5}3-{S5}7, {S5}22-{S5}26)
Sequence Shortening

Ac-{Arg(β-Glu(1→4)-α-Glu)}-L-{S5}-KDK-{S5}-KGIGKLAGKAALGA-{S5}-KTL-{S5}-NH2 (RCM bridge: {S5}3-{S5}7, {S5}22-{S5}26)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PP-60 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PP-60PP60PP 60ApoptosisapoptosisHepG2 xenograft nude miceHepG2 cellsA549 cellsPC-3 cellsliver cancerlung cancerprostate cancerInhibitorinhibitorinhibit

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