2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Topoisomerase
  4. Premafloxacin

Premafloxacin 是一种强效的抗菌 (antimicrobial) 剂，对金黄色葡萄球菌、牛型棒状杆菌和淀粉样棒状杆菌均具有活性。Premafloxacin 通过靶向拓扑异构酶 IV (topoisomerase IV) 对 S. aureus 表现出强效的抗菌活性，且是 NorA 外排泵的弱底物。Premafloxacin 可用于抗菌研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Premafloxacin

Premafloxacin Chemical Structure

CAS No. : 143383-65-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Premafloxacin 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II DNA gyrase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Premafloxacin is a potent antimicrobial agent that exhibits activity against Staphylococcus aureus, Corynebacterium bovis, and Corynebacterium amylocolatum. Premafloxacin demonstrated potent antimicrobial activity against S. aureus by targeting topoisomerase IV, and is a poor substrate for NorA efflux pump. Premafloxacin can be used for antimicrobial research[1][2].

IC50 & Target[1]

TOPO IV

 

体外研究
(In Vitro)

Premafloxacin (24-48 小时) 对金黄色葡萄球菌野生型 ISP794 表现出活性，其 MIC 为 0.004-0.008 μg/mL；而对这两种菌株中拓扑异构酶 IV 亚基发生改变的 grlA 和 grlB 突变株，其活性下降 4-8 倍，MIC 为 0.032-0.064 μg/mL[1]。
Premafloxacin (2-8 × MIC；48 小时) 在 4 × 或更高浓度的 S. aureus ISP794 的 MIC 值下未能筛选出单步耐药突变体，仅在 2× MIC 浓度下可检测到耐药突变体 (突变频率：6.4×10-10 至 4.0×10-7)[1]。
Premafloxacin (24 小时) 对从牛乳腺中分离的牛棒状杆菌 (Corynebacterium bovis) 和淀粉样棒状杆菌 (Corynebacterium amylocolatum) 菌株均表现出强效的体外活性，其 MIC90 为 0.015 μg/mL[2]。
Premafloxacin (24-48 小时) 对过度表达 NorA 外排泵的 flqB 突变株的活性降低 2 倍，表明其是 NorA 的较弱底物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Premafloxacin 相关抗体:
分子量

403.45

Formula

C21H26FN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Premafloxacin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Premafloxacin143383-65-7BacterialTopoisomerasetopoisomerase IVNorA efflux pumpStaphylococcus aureusCorynebacterium amylocolatumbovine mammary glandsQRDRCorynebacterium bovisgrlA mutationsbovine mastitistopoisomerase IV-DNA complexesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Premafloxacin
目录号：
HY-180414
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z