2. Anti-infection
  3. Bacterial
  4. PV-DPD-19

PV-DPD-19 是一种自诱导物-2 (AI-2) 群体感应抑制剂。PV-DPD-19 减少 AI-2 生成量、抑制多种 MSCRAMM 的表达。PV-DPD-19 在与金黄色葡萄球菌共培养的体系中，可减少铜绿假单胞菌绿脓菌素和弹性蛋白酶的产生。PV-DPD-19 削弱金黄色葡萄球菌对肺上皮细胞的黏附能力。PV-DPD-19 抑制铜绿假单胞菌 (MBIC50 = 27 μg/mL) 和金黄色葡萄球菌 (MBIC50 = 35 μg/mL) 的生物膜形成。PV-DPD-19 在体外肺上皮细胞及体内大蜡螟幼虫模型中均无细胞毒性。

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PV-DPD-19

PV-DPD-19 Chemical Structure

CAS No. : 3112321-20-4

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PV-DPD-19 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PV-DPD-19 is an autoinducer-2 (AI-2) quorum sensing inhibitor. PV-DPD-19 reduces AI-2 production and inhibits the expression of multiple MSCRAMMs. In co-culture systems with *Staphylococcus aureus*, PV-DPD-19 decreases the production of pyocyanin and elastase in *Pseudomonas aeruginosa*. PV-DPD-19 impairs the adhesion ability of *Staphylococcus aureus* to lung epithelial cells. PV-DPD-19 inhibits biofilm formation of *Pseudomonas aeruginosa* (MBIC50 = 27 μg/mL) and *Staphylococcus aureus* (MBIC50 = 35 μg/mL). PV-DPD-19 shows no cytotoxicity in both in vitro lung epithelial cell models and in vivo *Galleria mellonella* larva models[1].

体外研究
(In Vitro)

PV-DPD-19 抑制铜绿假单胞菌 (MBIC50 = 27 μg/mL) 和金黄色葡萄球菌 (MBIC50 = 35 μg/mL) 的生物膜形成[1]。
PV-DPD-19 可使金黄色葡萄球菌对 A549 上皮细胞的黏附率显著降低约 30%[1]。
PV-DPD-19 (2 mM; overnight, 8 h) 可通过哈维弧菌生物发光测定显著降低金黄色葡萄球菌 SH1000 的 AI-2 生成量[1]。
PV-DPD-19 (20-40 μM; 16 h) 以剂量依赖方式降低铜绿假单胞菌 PAO1 的绿脓菌素生成[1]。
PV-DPD-19 (3.12-200 μM; 24 h) 对上皮细胞 A549 无细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PV-DPD-19 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human alveolar basal epithelial carcinoma A549 cells
Concentration: 3.12-200 μM
Incubation Time: 24 h
Result: Maintained cell viability at 100% for all compounds.
Showed no statistically significant reduction in viability.
体内研究
(In Vivo)

PV-DPD-19 (1-200 μM；用微量注射器注入前腹足；单剂量) 在浓度高达 200 μM 时，对 Galleria mellonella (大蜡螟) 幼虫无可见急性毒性，72 小时内存活率维持在 ≥97%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: larvae (0.2-0.3 g in weight)[1]
Dosage: 1 μM; 100 μM; 200 μM
Administration: injected into the proleg using a microsyringe; single dose
Result: Observed 100% survival at 24 hours post-injection for all doses.
Observed 100% survival at 48 hours post-injection for 1 μM and 200 μM doses, and 97% survival for 100 μM dose.
Observed 98% survival at 72 hours post-injection for 1 μM and 200 μM doses, and 97% survival for 100 μM dose.
Showed no significant survival difference compared to untreated controls.
分子量

293.32

Formula

C15H19NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PV-DPD-19 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PV-DPD-193112321-20-4Bacterialα-hemolysinquorum sensing inhibitorpyocyaninelastaseStaphylococcus aureusPseudomonas aeruginosaGalleria mellonellaprotein SpAautoinducer-2human lung epithelial cellsInhibitorinhibitorinhibit

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