2. Membrane Transporter/Ion Channel
  3. Na+/Ca2+ Exchanger
  4. SAR296968

SAR296968 是一种 Na+/Ca2+交换体 (NCX) 亚型抑制剂，对 hNCX1 的 IC50 值为 74 nM。SAR296968 抑制 NCX 电流的正向和反向模式。SAR296968 可提升心脏收缩力和每搏输出量。SAR296968 具有抗心律失常作用。SAR296968 可用于心力衰竭的相关研究。

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SAR296968

SAR296968 Chemical Structure

CAS No. : 1426899-28-6

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SAR296968 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAR296968 is a Na+/Ca2+ exchanger (NCX) subtype inhibitor with an IC50 value of 74 nM against hNCX1. SAR296968 inhibits both forward and reverse modes of NCX current. SAR296968 enhances cardiac contractility and stroke volume. SAR296968 exerts antiarrhythmic effects. SAR296968 is applicable to research related to heart failure[1].

体外研究
(In Vitro)

SAR296968 可强效抑制 CHO 细胞系中 hNCX1，IC50 值为 74 nM[1]。
SAR296968 可强效抑制豚鼠心肌细胞中内源性 NCX 电流的正向和反向模式，对应的 IC50 值分别为 34.9 nM 和 38.9 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SAR296968 相关抗体:
体内研究
(In Vivo)

SAR296968 (1.5 mg/kg；静脉注射; 持续 20 分钟) 可使麻醉猪的左心室收缩力提升 49%，并将电诱导的心房心律失常发生率降低 74%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified strain (pentobarbital-anesthetized)[1]
Dosage: 1.5 mg/kg
Administration: i.v.; over 20 minutes
Result: Increased left ventricular contractility by 49% (dP/dtmax rose from 1423 ± 144 mm Hg/s at baseline to 2115 ± 189 mm Hg/s post-infusion).
Reduced the incidence of atrial arrhythmias by 74% (6.56 ± 1.99 events post-treatment vs.
25.50 ± 1.75 events at baseline, n=8, P<0.001).
Showed no changes in left or right atrial effective refractory period regardless of basic cycle length.
分子量

410.49

Formula

C22H22N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SAR296968 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

SAR2969681426899-28-6SAR 296968SAR-296968Na+/Ca2+ Exchangerheart failureNa+/Ca2+ exchanger (NCX)CHO cell linesmongrel dogsNCX isoformssympathovagal balanceantiarrhythmic agentpacing-induced heart failurebaroreflex sensitivityguinea pig cardiomyocytesInhibitorinhibitorinhibit

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产品名称：
SAR296968
目录号：
HY-182252
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