2. Apoptosis PI3K/Akt/mTOR GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Apoptosis PI3K Akt mTOR Adrenergic Receptor GABA Receptor Beta-secretase Bcl-2 Family
  4. Scoulerine hydrochloride

Scoulerine hydrochloride  (Synonyms: (-)-Scoulerine hydrochloride; Discretamine hydrochloride)

目录号: HY-N1255A
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Scoulerine hydrochloride 是一种多靶点抑制剂，具有抗肿瘤和抗氧化活性。Scoulerine hydrochloride 主要靶向 PI3K/Akt/mTOR 信号轴和 α1D-肾上腺素能受体，破坏微管结构并诱导细胞周期阻滞与凋亡。Scoulerine hydrochloride 有效抑制线粒体脱氢酶活性，靶向 GABA 受体和 BACE1，抑制癌细胞的增殖、迁移、侵袭、上皮间质转化及干细胞特性。Scoulerine hydrochloride 还具备抗恶性疟原虫、抗菌、止吐镇咳等多重药理活性，并能调节内质网应激及线粒体功能 (调控 Bax、Bcl-2 和细胞色素 c)。Scoulerine hydrochloride 可用于白血病、卵巢癌及结直肠癌的相关研究。

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Scoulerine hydrochloride

Scoulerine hydrochloride Chemical Structure

CAS No. : 51486-68-1

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规格 价格 是否有货 数量
1 mg ￥640
1 - 2 周
5 mg ￥2240
1 - 2 周
10 mg ￥3600
1 - 2 周
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Scoulerine hydrochloride:

Scoulerine hydrochloride 相关抗体

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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α adrenergic receptor β adrenergic receptor

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Scoulerine hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine hydrochloride mainly targets the PI3K/Akt/mTOR signaling axis and α1D-adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine hydrochloride effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine hydrochloride also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine hydrochloride is applicable to research related to leukemia, ovarian cancer, and colorectal cancer[1][2][3].

IC50 & Target[1][2]

mTOR

 

Bak

 

BACE1

 

Alpha-1D adrenergic receptor

 

体外研究
(In Vitro)

Scoulerine (1-50 μM；72 h) 对人肺癌 A549 细胞、卵巢癌 A2780 细胞、乳腺癌 SK-BR-3 细胞和 MCF-7 细胞具有抗增殖活性，低浓度 (1 μM、5 μM) 对细胞增殖影响较小或略有延迟，高浓度 (10 μM、20 μM、50 μM) 则显著抑制细胞增殖[2]。
Scoulerine (2.5-20 μM；24 h) 诱导 Jurkat 和 MOLT-4 白血病细胞凋亡，早期和晚期凋亡率均呈剂量依赖性增加，且能通过 TUNEL assay 检测到 DNA 片段化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Scoulerine hydrochloride 相关抗体:

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[2]

Cell Line: Jurkat, MOLT-4, Raji, HL-60, U-937, HEL 92.1.7, A549, A2780, SK-BR-3, MCF-7
Concentration: 1 μM, 5 μM, 10 μM, 15 μM, 20 μM, 50 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Reduced the viability and proliferation of leukemic cells in a dose-dependent manner within 24 h, and the reduction was more pronounced at 48 h.
For adherent cell lines, low concentrations (1 μM, 5 μM) had no significant effect or slightly delayed proliferation, while high concentrations (10 μM, 20 μM, 50 μM) exerted a potent antiproliferative effect over 72 h.
The IC50 values of scoulerine against human leukemic cells ranged from 2.7 to 6.5 μM as determined by XTT assay.
IC50 values: 2.7 ± 0.1 μM (Jurkat), 4.2 ± 0.2 μM (HL-60), 4.7 ± 0.2 μM (MOLT-4), 4.8 ± 0.3 μM (U-937), 6.3 ± 0.8 μM (HEL 92.1.7), 6.5 ± 0.7 μM (Raji).

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[2]

Cell Line: A549
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 h
Result: Disrupted the microtubule structure at 10 μM and 20 μM, leading to dense aggregation of microtubules around cell nuclei and reduced density at the cell periphery.
At 5 μM, the tubulin network remained almost intact similar to the control cells.
分子量

363.84

Formula

C19H22ClNO4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Scoulerine hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Scoulerine51486-68-1(-)-ScoulerineDiscretamineApoptosisPI3KAktmTORAdrenergic ReceptorGABA ReceptorBeta-secretaseBcl-2 FamilyPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinBeta ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorBACEβ-SecretasePI3K/Akt/mTOR axisepithelial-mesenchymal transitioncolorectal cancer cellsα1D-adrenoreceptorBACE1GABA receptorsovarian cancer mouse modelsPlasmodium falciparumleukemic cellsovarian cancer xenograft mouse modelsInhibitorinhibitorinhibit

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