戈米辛N
Gomisin N 是一种口服活性的木脂素化合物。Gomisin N 可从 Schisandra chinensis 中分离得到。Gomisin N 在多种细胞中诱导凋亡 (Apoptosis)。Gomisin N 激活 AMPK、Akt、MAPK/ERK、Nrf2、caspase-3 和 PARP-1。Gomisin N 抑制 GSK3β、一氧化氮 (NO) 和促炎细胞因子 (IL-1β、IL-6、TNF-α)。Gomisin N 具有抗炎、抗氧化、抗肥胖、抗糖尿病、抑制黑色素生成活性。Gomisin N 对宫颈癌和肝癌具有抗肿瘤活性。Gomisin N 改善阿尔兹海默症。
大豆皂苷Ab
Soyasaponin Ab 是一种有口服活性的大豆皂苷。Soyasaponin Ab 可抑制 PPARγ 转录活性。高浓度的 Soyasaponin Ab 可诱导细胞凋亡 (apoptosis)。Soyasaponin Ab 具有抗肥胖、抗氧化、抗炎和抗衰老作用。Soyasaponin Ab 可预防 Scopolamine (HY-N0296) 引起的记忆力减退。
桔梗皂苷 D (标准品)
Platycodin D (Standard)是 Platycodin D 的分析标准品。本产品用于研究及分析应用。Platycodin D 是可从桔梗中分离得到的皂苷类化合物，为 AMPKα 的激活剂，具有抗肥胖活性。WNT/β-catenin 通路介导 Platycodin D 的抗成脂作用。
达木林B
Damulin B 是一种被发现在绞股蓝 (Gynostemma pentaphyllum) 中的达玛烷型皂苷。Damulin B 能够抑制癌细胞凋亡 (apoptosis)，降低线粒体膜电位，抑制活性氧 (apoptosis) 的产生，并导致 G0/G1 期阻滞。Damulin B 可预防 Cisplatin (HY-17394) 诱导的急性肾损伤，并能促进毛发生长。Damulin B 具有抗炎、抗糖尿病和抗肥胖的作用。Damulin B 可用于癌症、炎症、代谢性疾病的研究，如肺癌、骨关节炎和糖尿病。
莱苞迪甙 A (标准品)
Rebaudioside A (Standard) 是 Rebaudioside A 的分析标准品。本产品用于研究及分析应用。Rebaudioside A 是一种口服有效的甜菊醇糖苷，具有较高的甜味。Rebaudioside A 是 α-glucosidase 抑制剂，IC50 值是 35.01 μg/mL。Rebaudioside A 通过葡萄糖依赖性的方式，增加 β 细胞内的 ATP/ADP 比值，从而抑制 KATP 通道，导致细胞膜去极化、钙离子内流，最终刺激胰岛素分泌。Rebaudioside A 通过抑制胆固醇合成的限速酶 HMGCR，激活 SREBP 信号通路，导致细胞表面 LDLR 表达增加，从而促进血液中 LDL-C 的摄取。Rebaudioside A 可用于研究血糖、血脂调节和抗肥胖。
泽泻醇A
Alisol A 是一种口服活性的原萜烷型四环三萜类化合物。Alisol A 可从泽泻 (Alisma orientale) 根茎中提取。Alisol A 激活 AMPK/ACC/SREBP-1c、SIRT1、PPARα，抑制 MMP-2/-9、减少炎症细胞因子表达 (IL-1β、IL-6、IL-8)。Alisol A 对乳腺癌、结直肠癌具有抗肿瘤活性。Alisol A 具有抗肥胖、抗动脉粥样硬化活性。Alisol A 可用于乙型肝炎、乳腺癌、结直肠癌、动脉粥样硬化、肥胖的研究。
泽泻醇A (标准品)
Alisol A (Standard) 是 Alisol A (HY-N0853) 的分析标准品。本产品用于研究及分析应用。Alisol A 是一种口服活性的原萜烷型四环三萜类化合物。Alisol A 可从泽泻 (Alisma orientale) 根茎中提取。Alisol A 激活 AMPK/ACC/SREBP-1c、SIRT1、PPARα，抑制 MMP-2/-9、减少炎症细胞因子表达 (IL-1β、IL-6、IL-8)。Alisol A 对乳腺癌、结直肠癌具有抗肿瘤活性。Alisol A 具有抗肥胖、抗动脉粥样硬化活性。Alisol A 可用于乙型肝炎、乳腺癌、结直肠癌、动脉粥样硬化、肥胖的研究。
泽泻醇A
Alisol A 是一种口服活性的原萜烷型四环三萜类化合物。Alisol A 可从泽泻 (Alisma orientale) 根茎中提取。Alisol A 激活 AMPK/ACC/SREBP-1c、SIRT1、PPARα，抑制 MMP-2/-9、减少炎症细胞因子表达 (IL-1β、IL-6、IL-8)。Alisol A 对乳腺癌、结直肠癌具有抗肿瘤活性。Alisol A 具有抗肥胖、抗动脉粥样硬化活性。Alisol A 可用于乙型肝炎、乳腺癌、结直肠癌、动脉粥样硬化、肥胖的研究。
戈米辛N
Gomisin N 是一种口服活性的木脂素化合物。Gomisin N 可从 Schisandra chinensis 中分离得到。Gomisin N 在多种细胞中诱导凋亡 (Apoptosis)。Gomisin N 激活 AMPK、Akt、MAPK/ERK、Nrf2、caspase-3 和 PARP-1。Gomisin N 抑制 GSK3β、一氧化氮 (NO) 和促炎细胞因子 (IL-1β、IL-6、TNF-α)。Gomisin N 具有抗炎、抗氧化、抗肥胖、抗糖尿病、抑制黑色素生成活性。Gomisin N 对宫颈癌和肝癌具有抗肿瘤活性。Gomisin N 改善阿尔兹海默症。
大豆皂苷Ab
Soyasaponin Ab 是一种有口服活性的大豆皂苷。Soyasaponin Ab 可抑制 PPARγ 转录活性。高浓度的 Soyasaponin Ab 可诱导细胞凋亡 (apoptosis)。Soyasaponin Ab 具有抗肥胖、抗氧化、抗炎和抗衰老作用。Soyasaponin Ab 可预防 Scopolamine (HY-N0296) 引起的记忆力减退。
达木林B
Damulin B 是一种被发现在绞股蓝 (Gynostemma pentaphyllum) 中的达玛烷型皂苷。Damulin B 能够抑制癌细胞凋亡 (apoptosis)，降低线粒体膜电位，抑制活性氧 (apoptosis) 的产生，并导致 G0/G1 期阻滞。Damulin B 可预防 Cisplatin (HY-17394) 诱导的急性肾损伤，并能促进毛发生长。Damulin B 具有抗炎、抗糖尿病和抗肥胖的作用。Damulin B 可用于癌症、炎症、代谢性疾病的研究，如肺癌、骨关节炎和糖尿病。
桔梗皂苷 D (标准品)
Platycodin D (Standard)是 Platycodin D 的分析标准品。本产品用于研究及分析应用。Platycodin D 是可从桔梗中分离得到的皂苷类化合物，为 AMPKα 的激活剂，具有抗肥胖活性。WNT/β-catenin 通路介导 Platycodin D 的抗成脂作用。
莱苞迪甙 A (标准品)
Rebaudioside A (Standard) 是 Rebaudioside A 的分析标准品。本产品用于研究及分析应用。Rebaudioside A 是一种口服有效的甜菊醇糖苷，具有较高的甜味。Rebaudioside A 是 α-glucosidase 抑制剂，IC50 值是 35.01 μg/mL。Rebaudioside A 通过葡萄糖依赖性的方式，增加 β 细胞内的 ATP/ADP 比值，从而抑制 KATP 通道，导致细胞膜去极化、钙离子内流，最终刺激胰岛素分泌。Rebaudioside A 通过抑制胆固醇合成的限速酶 HMGCR，激活 SREBP 信号通路，导致细胞表面 LDLR 表达增加，从而促进血液中 LDL-C 的摄取。Rebaudioside A 可用于研究血糖、血脂调节和抗肥胖。
泽泻醇A (标准品)
Alisol A (Standard) 是 Alisol A (HY-N0853) 的分析标准品。本产品用于研究及分析应用。Alisol A 是一种口服活性的原萜烷型四环三萜类化合物。Alisol A 可从泽泻 (Alisma orientale) 根茎中提取。Alisol A 激活 AMPK/ACC/SREBP-1c、SIRT1、PPARα，抑制 MMP-2/-9、减少炎症细胞因子表达 (IL-1β、IL-6、IL-8)。Alisol A 对乳腺癌、结直肠癌具有抗肿瘤活性。Alisol A 具有抗肥胖、抗动脉粥样硬化活性。Alisol A 可用于乙型肝炎、乳腺癌、结直肠癌、动脉粥样硬化、肥胖的研究。
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
