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Myc axis

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By Targets:	c-Myc (3) Akt (1) Apoptosis (1) Bcl-2 Family (1) DNA/RNA Synthesis (1) Epigenetic Reader Domain (1) ERK (1) Ferroptosis (1) FOXO (1) Glutathione Peroxidase (1) GSK-3 (1) JNK (2) MASTL (1) p38 MAPK (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (4) Infection (1) Metabolic Disease (1)

抑制剂 & 激动剂

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Targets Recommended: c-Myc

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-N0863

Methyl protodioscin NSC-698790; Smilax saponin B	Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO	Cancer
Methyl protodioscin (NSC-698790；Smilax saponin B) 是一种多靶点的选择性、甾二糖苷型抑制剂，具有抗肿瘤活性，能诱导细胞周期阻滞。Methyl protodioscin 的作用机制复杂，通过诱导 G2/M 细胞周期阻滞、调节 Bcl-2/Bax 凋亡 (apoptosis) 通路、抑制 Akt1/c-Myc 轴及 MAPK/ERK 信号，同时下调 ADAM15、诱导 FOXO1 以减少胆固醇合成，还能抑制 JNK/c-Jun 通路降低炎症因子 (IL-6、TNF-α) 产生。Methyl protodioscin 具有显著的抗肿瘤 (抑制增殖、迁移、侵袭并诱导凋亡)、抗炎及抗血管再狭窄活性。Methyl protodioscin 可用于肺癌、前列腺癌、胰腺癌等肿瘤，气道炎症、肠炎等炎症性疾病的研究。

HY-N10549

Gigantol 1 篇文献验证	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3	Infection Metabolic Disease Cancer
Gigantol 是一种具有口服活性的联苄类化合物。Gigantol 靶向 *MYC* 促进其泛素 - 蛋白酶体降解并抑制肺癌细胞生长。Gigantol 通过 SLC7A11-GPX4 轴诱导铁死亡 (Ferroptosis)，从而发挥抗肺癌活性。Gigantol 可恢复携带 mcr 的多重耐药菌对粘菌素的敏感性。Gigantol 通过抑制 JNK/cPLA2/12-LOX 炎症通路的激活改善四氯化碳诱导的肝损伤。Gigantol 促进睾丸间质细胞中的胆固醇代谢和孕酮生物合成。Gigantol 可用于肺癌、多重耐药革兰氏阴性菌感染、急性肝损伤等疾病的相关研究。

HY-182036

KWZL-7f15	Epigenetic Reader Domain	Cancer
KWZL-7f15 (compound 7f15) 是一种双重 CDK6/BET 抑制剂，对人源 CDK6 的 IC₅₀ 为 31.81 nM。KWZL-7f15 可抑制 CDK6-RB 轴与 BRD4-*Myc* 轴。KWZL-7f15 对三阴性乳腺癌细胞具有抗增殖活性。KWZL-7f15 在异种移植小鼠模型中展现出抗肿瘤活性，且无显著不良反应。KWZL-7f15 可用于三阴性乳腺癌的相关研究。

HY-185310

MKI-2	MASTL c-Myc DNA/RNA Synthesis	Cancer
MKI-2 是一种选择性 MASTL 抑制剂，其 IC₅₀ 为 37.44 nM。MKI-2 可诱导乳腺癌细胞中因 MASTL-PP2A 轴调控异常而产生的有丝分裂灾难。MKI-2 可降低磷酸化 ENSA、总 c-Myc 及磷酸化 c-Myc 的水平。MKI-2 可抑制癌细胞的增殖与迁移，并诱导 DNA 损伤。MKI-2 可抑制小鼠卵母细胞的生发泡破裂。MKI-2 可用于癌症相关研究，例如乳腺癌研究。

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0863

Methyl protodioscin NSC-698790; Smilax saponin B	Structural Classification other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO
Methyl protodioscin (NSC-698790；Smilax saponin B) 是一种多靶点的选择性、甾二糖苷型抑制剂，具有抗肿瘤活性，能诱导细胞周期阻滞。Methyl protodioscin 的作用机制复杂，通过诱导 G2/M 细胞周期阻滞、调节 Bcl-2/Bax 凋亡 (apoptosis) 通路、抑制 Akt1/c-Myc 轴及 MAPK/ERK 信号，同时下调 ADAM15、诱导 FOXO1 以减少胆固醇合成，还能抑制 JNK/c-Jun 通路降低炎症因子 (IL-6、TNF-α) 产生。Methyl protodioscin 具有显著的抗肿瘤 (抑制增殖、迁移、侵袭并诱导凋亡)、抗炎及抗血管再狭窄活性。Methyl protodioscin 可用于肺癌、前列腺癌、胰腺癌等肿瘤，气道炎症、肠炎等炎症性疾病的研究。

HY-N10549

Gigantol 1 篇文献验证	Structural Classification Classification of Application Fields Orchidaceae Other Diseases Phenols Polyphenols Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3
Gigantol 是一种具有口服活性的联苄类化合物。Gigantol 靶向 *MYC* 促进其泛素 - 蛋白酶体降解并抑制肺癌细胞生长。Gigantol 通过 SLC7A11-GPX4 轴诱导铁死亡 (Ferroptosis)，从而发挥抗肺癌活性。Gigantol 可恢复携带 mcr 的多重耐药菌对粘菌素的敏感性。Gigantol 通过抑制 JNK/cPLA2/12-LOX 炎症通路的激活改善四氯化碳诱导的肝损伤。Gigantol 促进睾丸间质细胞中的胆固醇代谢和孕酮生物合成。Gigantol 可用于肺癌、多重耐药革兰氏阴性菌感染、急性肝损伤等疾病的相关研究。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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