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SA-β-Gal

" in MCE Product Catalog:

By Targets:	Apoptosis (1) CDK (2) Epigenetic Reader Domain (1) Fluorescent Dye (4) Glycosidase (1) PROTACs (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (1)

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-158742

SBB-Analogue (GL13) Biotin 1 篇文献验证 GL13; SBB-A-B	Fluorescent Dye	Others
SBB-Analogue (GL13) Biotin (GL13; SBB-A-B) 由与生物素结合的 Sudan Black B (SBB; HY-D0213) 衍生物组成。SBB-Analogue (GL13) Biotin 强效检测衰老细胞，可消除 SA-β-gal 因血清饥饿和细胞融合产生的假阳性染色的缺陷。SBB-Analogue (GL13) Biotin 可以用于流式细胞术和免疫荧光分析等。

HY-100023

LY3177833	CDK	Cancer
LY3177833 (Example 4) 是一种具有口服活性的 CDC7 和 pMCM2 的抑制剂，其 IC₅₀ 值分别为 3.3 nM 和 290 nM。LY3177833 是一种衰老诱导剂。

HY-100023A

LY3177833 monhydrate	CDK	Cancer
LY3177833 (Example 4) monhydrate 是一种具有口服活性的 CDC7 和 pMCM2 的抑制剂，其 IC₅₀ 值分别为 3.3 nM 和 290 nM。LY3177833 monhydrate 是一种衰老诱导剂。

HY-165424

NIR-BG2	Fluorescent Dye Glycosidase	Cardiovascular Disease Cancer
NIR-BG2 是一种靶向衰老相关 β-半乳糖苷酶 (SA-β-Gal) 的近红外荧光探针。NIR-BG2 被 SA-β-Gal 激活后水解释放出亲电的甲基醌，与周围蛋白共价结合进行原位标记，在 709 nm 处荧光信号增强 16 倍。NIR-BG2 有望用于细胞衰老的体内成像研究。

HY-158331

Gal-ARV-771	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
Gal-ARV-771 是一种 PROTAC 前药，是半乳糖修饰的 ARV-771 (HY-100972)。Gal-ARV-771 可在表达 SA-β-Gal 的衰老癌症细胞中被激活，从而释放 ARV-771。Gal-ARV-771 通过泛素-蛋白酶体途径在衰老细胞中诱导 BRD4 蛋白选择性降解。Gal-ARV-771 促进衰老癌细胞凋亡 (apoptosis)。

HY-177945

MS99-β-Gal Gal-MS99	PROTACs	Cancer
MS99-β-Gal (Gal-MS99) 是一种半乳糖修饰的 NPM-ALK PROTAC 降解剂。MS99-β-Gal 仅在衰老癌细胞中被 SA-β-半乳糖苷酶 (SA-β-gal) 和酯酶水解，释放出 MS99，特异性降解 NPM-ALK 融合蛋白。MS99-β-Gal 对衰老的 Karpas 299 细胞的 IC₅₀ 值为 454.8 nM，显著低于对正常 Karpas 299 细胞 (IC₅₀ = 2.162 μM)。MS99-β-Gal 可用于癌症研究。

HY-D2992

KSA02	Fluorescent Dye	Cancer
KSA02 是一种双维度的智能荧光探针。KSA02 不仅检测衰老相关β-半乳糖苷酶 (SA-β-gal) 的活性，还能同时感知 SA-β-gal 所在的溶酶体微环境的 pH 值变化。KSA02 可区分衰老与癌症、追踪衰老进程、评估抗衰老剂的效果。KSA02 可用于研究衰老生物学。

HY-D2990

KSA01	Fluorescent Dye	Others
KSA01 是一种二维荧光探针。KSA01 可以检测 SA-β-gal 活性和感知溶酶体 pH。KSA01 能精准区分细胞衰老与其他高表达 β-gal 的病理状态。

Cat. No.	Product Name	Type

HY-D2992

KSA02	Fluorescent Dye
KSA02 是一种双维度的智能荧光探针。KSA02 不仅检测衰老相关β-半乳糖苷酶 (SA-β-gal) 的活性，还能同时感知 SA-β-gal 所在的溶酶体微环境的 pH 值变化。KSA02 可区分衰老与癌症、追踪衰老进程、评估抗衰老剂的效果。KSA02 可用于研究衰老生物学。

HY-D2990

KSA01	Fluorescent Dye
KSA01 是一种二维荧光探针。KSA01 可以检测 SA-β-gal 活性和感知溶酶体 pH。KSA01 能精准区分细胞衰老与其他高表达 β-gal 的病理状态。

NIR-BG2	Alkaloids Other Alkaloids Cananga odorata Plants Annonaceae Indole Alkaloids Source Classification	Fluorescent Dye Glycosidase
NIR-BG2 是一种靶向衰老相关 β-半乳糖苷酶 (SA-β-Gal) 的近红外荧光探针。NIR-BG2 被 SA-β-Gal 激活后水解释放出亲电的甲基醌，与周围蛋白共价结合进行原位标记，在 709 nm 处荧光信号增强 16 倍。NIR-BG2 有望用于细胞衰老的体内成像研究。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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SA-β-Gal

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