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estrous

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By Targets:	Endogenous Metabolite (3) Estrogen Receptor/ERR (2) GABA Receptor (1) GnRH Receptor (2)
By Research Areas:	Cardiovascular Disease (1) Endocrinology (4) Metabolic Disease (1) Neurological Disease (2)

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-N12634

Pregnant mare serum gonadotropin PMSG	Endogenous Metabolite	Metabolic Disease
Pregnant mare serum gonadotropin (PMSG) 是一种促性腺激素，可用于促进动物的卵泡发育和排卵。Pregnant mare serum gonadotropin 通过刺激体内血液激素、促性腺激素和前脑垂体及下丘脑细胞质雌二醇受体的相关变化来发挥其调节作用。Pregnant mare serum gonadotropin 常用于畜牧业以提高繁殖效率，也可用于研究发情周期调节。

HY-W007566

5-Methoxyindole-3-acetic acid	Endogenous Metabolite	Endocrinology
5-Methoxyindole-3-acetic acid 是 Melatonin (HY-B0075) 的一种代谢产物。5-Methoxyindole-3-acetic acid 显著延长雌性大鼠发情周期、增加子宫重量并诱导卵巢卵泡囊肿，同时调节相关激素水平。

HY-N2026A

Propylparaben sodium 1 篇文献验证 Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium	Estrogen Receptor/ERR	Cardiovascular Disease Neurological Disease
羟苯丙酯钠 Propylparaben sodium 是一种有口服活性的弱雌激素受体激动剂。Propylparaben sodium可调控 PI3K-AKT 和 JNK 信号通路，诱导氧化应激，并改变动情周期、激素水平及卵巢储备功能。Propylparaben sodium可制窦状卵泡生长，并改变卵泡培养基中类固醇激素的积累。Propylparaben sodium 可用于卵巢衰老、心肌缺血再灌注损伤相关研究[1][2][3][4][5]。

HY-125611

Fluorogestone acetate	GnRH Receptor	Endocrinology
黄体酮杂质9；醋酸氟孕酮 Fluorogestone acetate 是一种黄体酮化合物。Fluorogestone acetate 通过抑制脑下垂体黄体生成素 (LH) 的释放来抑制牛的排卵和同步发情周期。

HY-117038

Anordiol	Estrogen Receptor/ERR	Endocrinology
Anordiol 是一种具有弱雌激素活性的抗雌激素化合物。Anordiol 能够降低雌二醇诱导的大鼠子宫生长参数 (包括子宫湿重、可溶性蛋白含量和 DNA 含量)，并可调节大鼠动情周期。Anordiol 抗雌激素相关疾病的研究中具有潜在应用价值。

HY-P0037

Org-30850 Org 30850ANT	GnRH Receptor	Endocrinology
Org-30850 是一种强效 LHRH 拮抗剂，用于研究激素依赖性疾病。在动物研究中，单次皮下剂量可有效抑制大鼠排卵，并在给药后长达 48 小时内显着降低雄性大鼠的睾酮水平。雌性大鼠每日服用 Org-30850 可抑制发情周期、减轻子宫和卵巢重量，并降低血清雌二醇和 FSH 水平。在雄性大鼠中，长期处理会导致性腺功能和睾酮水平可逆性降低，停止后几乎完全恢复。与同类 LHRH 拮抗剂不同，Org-30850 的注射部位刺激最小，没有水肿反应。

HY-W644305

Androst-16-en-3-ol 3β-Androstenol	GABA Receptor Endogenous Metabolite	Neurological Disease
Androst-16-en-3-ol 是一种公猪的一种信息素，能引发发情母猪的交配反应，也存在于人类尿液、血浆、唾液和汗液中。Androst-16-en-3-ol 是一种内源性神经类固醇，可作为 GABA_A 受体 (GABA_A receptor) 正性调节剂，在小鼠中可产生抗焦虑、抗抑郁和抗惊厥活性。

Cat. No.	Product Name	Target	Research Area

HY-P0037

Org-30850 Org 30850ANT	GnRH Receptor	Endocrinology
Org-30850 是一种强效 LHRH 拮抗剂，用于研究激素依赖性疾病。在动物研究中，单次皮下剂量可有效抑制大鼠排卵，并在给药后长达 48 小时内显着降低雄性大鼠的睾酮水平。雌性大鼠每日服用 Org-30850 可抑制发情周期、减轻子宫和卵巢重量，并降低血清雌二醇和 FSH 水平。在雄性大鼠中，长期处理会导致性腺功能和睾酮水平可逆性降低，停止后几乎完全恢复。与同类 LHRH 拮抗剂不同，Org-30850 的注射部位刺激最小，没有水肿反应。

Pregnant mare serum gonadotropin PMSG	Structural Classification Natural Products Animals Source Classification	Endogenous Metabolite
Pregnant mare serum gonadotropin (PMSG) 是一种促性腺激素，可用于促进动物的卵泡发育和排卵。Pregnant mare serum gonadotropin 通过刺激体内血液激素、促性腺激素和前脑垂体及下丘脑细胞质雌二醇受体的相关变化来发挥其调节作用。Pregnant mare serum gonadotropin 常用于畜牧业以提高繁殖效率，也可用于研究发情周期调节。

5-Methoxyindole-3-acetic acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
5-Methoxyindole-3-acetic acid 是 Melatonin (HY-B0075) 的一种代谢产物。5-Methoxyindole-3-acetic acid 显著延长雌性大鼠发情周期、增加子宫重量并诱导卵巢卵泡囊肿，同时调节相关激素水平。

Propylparaben sodium 1 篇文献验证 Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium	Infection Structural Classification Natural Products Classification of Application Fields Cosmetic Research Endogenous metabolite Disease Research Fields Source Classification	Estrogen Receptor/ERR
羟苯丙酯钠 Propylparaben sodium 是一种有口服活性的弱雌激素受体激动剂。Propylparaben sodium可调控 PI3K-AKT 和 JNK 信号通路，诱导氧化应激，并改变动情周期、激素水平及卵巢储备功能。Propylparaben sodium可制窦状卵泡生长，并改变卵泡培养基中类固醇激素的积累。Propylparaben sodium 可用于卵巢衰老、心肌缺血再灌注损伤相关研究[1][2][3][4][5]。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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