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mucosal healing

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By Targets:	Aryl Hydrocarbon Receptor (1) CD47 (2) Cytochrome P450 (1) ERK (1) FAK (2) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (2) MMP (1) NF-κB (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) Prostaglandin Receptor (3) Reactive Oxygen Species (ROS) (1) TNF Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (2) Infection (2) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (1)

抑制剂 & 激动剂

抗体抑制剂

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-134570

ZINC40099027 3 篇文献验证	FAK	Metabolic Disease Inflammation/Immunology
ZINC40099027 是一种选择性 FAK 激活剂。ZINC40099027 促进 FAK 磷酸化，但不激活其旁系同源物 Pyk2 和 Src。ZINC40099027 通过激活 FAK 来促进人肠上皮单层细胞伤口闭合和小鼠溃疡愈合。ZINC40099027 可用于与胃肠道黏膜损伤相关的疾病研究。

HY-128686

KAG-308 3 篇文献验证	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
KAG-308 是一种有效、选择性、可口服的 EP4 receptor (一种前列腺素 E2 受体亚型) 激动剂，抑制结肠炎，促进组织粘膜愈合，有效抑制 TNF-α 的产生。KAG-308 对人 EP4 受体的 K_i 值和 EC₅₀ 值分别为 2.57 nM 和 17 nM，对其选择性高于 EP1，EP2，EP3 和 IP 受体。

HY-P990131

Anti-Mouse CD47/IAP Antibody (MIAP301) 1 篇文献验证	CD47	Infection Inflammation/Immunology Cancer
Anti-Mouse CD47/IAP Antibody (MIAP301) 是一种抗小鼠 CD47/IAP IgG2a 单克隆抗体。Anti-Mouse CD47/IAP Antibody (MIAP301) 能有效阻断 CD47 信号传导并增强巨噬细胞吞噬功能。Anti-Mouse CD47/IAP Antibody (MIAP301) 可以增加免疫细胞的浸润。Anti-Mouse CD47/IAP Antibody (MIAP301) 恢复髓系细胞吞噬功能并减轻 B 细胞抑制。Anti-Mouse CD47/IAP Antibody (MIAP301) 可能会干扰伤口愈合。Anti-Mouse CD47/IAP Antibody (MIAP301) 可用于研究癌症, 炎症疾病和感染性疾病如黑色素瘤, 肠粘膜修复和脓毒症。

HY-P990132

Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410)	CD47	Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 是一种抗小鼠/大鼠/人 CD47/IAP IgG1 单克隆抗体。Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 能有效阻断 CD47 信号传导并增强巨噬细胞吞噬功能。Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 可以增加免疫细胞的浸润。Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 可能会干扰伤口愈合。Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 可用于研究癌症和炎症疾病如乳腺癌和肠粘膜修复。

HY-170522

ISM012-042	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
ISM012-042 是一种口服有效的、选择性的 PHD1 和 PHD2 抑制剂，其 IC₅₀ 值分别为 1.9 nM 和 2.5 nM。ISM012-042 稳定肠道上皮细胞内的 HIF1α 蛋白，从而激活与粘液生成、紧密连接形成、抗炎介质产生和伤口愈合相关的基因转录程序，从根源上促进黏膜屏障修复并调节肠道免疫。ISM012-042 可用于炎症性肠病的研究。

HY-126941

Hecogenin acetate	ERK MMP Reactive Oxygen Species (ROS) NF-κB p38 MAPK NOD-like Receptor (NLR) TRP Channel TNF Receptor Interleukin Related	Infection Neurological Disease Inflammation/Immunology Endocrinology
龙舌兰皂苷乙酯 Hecogenin acetate 是一种口服有效的甾体皂苷元，具有广泛的生物活性。Hecogenin acetate 抑制 NF-κB 和 p38 MAPK 信号通路磷酸化，拮抗 TRPA1/TRPM8 通道，抑制促炎细胞因子产生，具有消炎镇痛的作用。Hecogenin acetate 抑制 ROS 产生和 NLRP3 炎症小体激活；下调 MMP-2 表达，具有神经保护和抗肿瘤活性。Hecogenin acetate 抑制醛固酮合酶基因表达，增加尿量和电解质排泄。Hecogenin acetate 可与某些抗生素联用，调节细菌外排泵，恢复抗生素敏感性。

HY-106054

Nocloprost	Prostaglandin Receptor	Metabolic Disease Inflammation/Immunology
诺氯前列素 Nocloprost 是一种口服有效的前列腺素 E2 (PGE2) 类似物，是一种 EP1 和 EP3 受体激动剂。Nocloprost 抑制诱发的 [³H]ACh 释放。Nocloprost 具有胃保护和溃疡愈合特性。Nocloprost 可加速大鼠慢性胃溃疡的愈合并增强粘膜生长。

HY-147128

PY109	Aryl Hydrocarbon Receptor Cytochrome P450 Interleukin Related	Inflammation/Immunology
PY109 是一种口服有效的、高选择性的芳基烃受体 (AHR) 激动剂，其在人源 HepG2 和小鼠 Hepa-1c1c7 细胞的 EC₅₀ 分别为 1.2 nM 和 1.4 nM。PY109 显著上调 CYP1A1 和 IL-22 的表达，且抑制了 IL-17A 的表达。PY109 显著改善了小鼠结肠炎。PY109 可用于研究结肠炎。

HY-119762

Spizofurone AG-629	Prostaglandin Receptor	Cardiovascular Disease
Spizofurone 是一种具有口服活性和增加胃粘膜血流量活性的抗溃疡化合物。Spizofurone 作用机制与 PGE2 (HY-101952) 类似，能够通过局部和系统性途径发挥作用，并且可能通过改善胃粘膜的血液供应来促进溃疡愈合。Spizofurone 可用于胃溃疡的发生和发展策略方面的研究。

HY-181487

FAK activator-1	FAK	Inflammation/Immunology
FAK activator-1 (5aHCl) 是一种 FAK 激活剂和黏膜愈合诱导剂。FAK activator-1 可提高 FAK 在 Tyr-397 位点的磷酸化水平，从而促进 FAK 激活。FAK activator-1 可促进黏膜愈合。FAK activator-1 可用于非甾体抗炎药相关胃肠道黏膜损伤的研究。

Cat. No.	Product Name	Target	Research Area	图片

HY-P990131

Anti-Mouse CD47/IAP Antibody (MIAP301) 1 篇文献验证	CD47	Infection Inflammation/Immunology Cancer
Anti-Mouse CD47/IAP Antibody (MIAP301) 是一种抗小鼠 CD47/IAP IgG2a 单克隆抗体。Anti-Mouse CD47/IAP Antibody (MIAP301) 能有效阻断 CD47 信号传导并增强巨噬细胞吞噬功能。Anti-Mouse CD47/IAP Antibody (MIAP301) 可以增加免疫细胞的浸润。Anti-Mouse CD47/IAP Antibody (MIAP301) 恢复髓系细胞吞噬功能并减轻 B 细胞抑制。Anti-Mouse CD47/IAP Antibody (MIAP301) 可能会干扰伤口愈合。Anti-Mouse CD47/IAP Antibody (MIAP301) 可用于研究癌症, 炎症疾病和感染性疾病如黑色素瘤, 肠粘膜修复和脓毒症。

HY-P990132

Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410)	CD47	Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 是一种抗小鼠/大鼠/人 CD47/IAP IgG1 单克隆抗体。Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 能有效阻断 CD47 信号传导并增强巨噬细胞吞噬功能。Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 可以增加免疫细胞的浸润。Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 可能会干扰伤口愈合。Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) 可用于研究癌症和炎症疾病如乳腺癌和肠粘膜修复。

Hecogenin acetate	Structural Classification Agave americana Linn. Agavaceae Plants Steroids Source Classification	ERK MMP Reactive Oxygen Species (ROS) NF-κB p38 MAPK NOD-like Receptor (NLR) TRP Channel TNF Receptor Interleukin Related
龙舌兰皂苷乙酯 Hecogenin acetate 是一种口服有效的甾体皂苷元，具有广泛的生物活性。Hecogenin acetate 抑制 NF-κB 和 p38 MAPK 信号通路磷酸化，拮抗 TRPA1/TRPM8 通道，抑制促炎细胞因子产生，具有消炎镇痛的作用。Hecogenin acetate 抑制 ROS 产生和 NLRP3 炎症小体激活；下调 MMP-2 表达，具有神经保护和抗肿瘤活性。Hecogenin acetate 抑制醛固酮合酶基因表达，增加尿量和电解质排泄。Hecogenin acetate 可与某些抗生素联用，调节细菌外排泵，恢复抗生素敏感性。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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mucosal healing

抑制剂 & 激动剂

抗体抑制剂

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