2. Apoptosis
  3. MDM-2/p53
  4. SEN205A

SEN205A 是一种能够结合人源 S100B 疏水口袋的片段化合物 (Kd=0.5-1.0 mM)，该位点正是 S100B 与 TRTK-12 及 p53 相互作用的关键区域，且 SEN205A 可被 TRTK-12 从该位点置换。SEN205A 具备优良的体外 ADME 特性，包括高代谢稳定性、化学稳定性以及在生理 pH 条件下的良好溶解性。SEN205A 可作为基于结构优化的起始片段，用于开发靶向 S100B-p53 蛋白-蛋白相互作用的抑制剂和恶性黑色素瘤发病机制。

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SEN205A

SEN205A Chemical Structure

CAS No. : 958712-85-1

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SEN205A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SEN205A is a fragment compound that binds to the hydrophobic pocket of human S100B (Kd = 0.5-1.0 mM), which is the key region for the interaction of S100B with TRTK-12 and p53, and SEN205A can be displaced from this site by TRTK-12. SEN205A exhibits excellent in vitro ADME properties, including high metabolic stability, chemical stability, and good solubility under physiological pH conditions. SEN205A can serve as a starting fragment for structure-based optimization to develop inhibitors targeting the S100B-p53 protein-protein interaction and investigate the pathogenesis of malignant melanoma[1].

体外研究
(In Vitro)

SEN205A (800 μM; 相对于单体 S100B 呈 5 倍摩尔过量；0.5-1 当量 TRTK-12) 可结合人源 S100B 的 p53/TRTK-12 相互作用位点，其估算 Kd 值为 0.5-1.0 mM，且可被高亲和力 TRTK-12 肽完全从该位点上置换下来[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SEN205A 相关抗体:
分子量

263.73

Formula

C13H14ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SEN205A 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEN205A958712-85-1MDM-2/p53human CYP3A4p53malignant melanomaS100BTRTK-12Inhibitorinhibitorinhibit

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HY-W237439
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