2. Membrane Transporter/Ion Channel
  3. Na+/HCO3- Cotransporter
  4. SOAT-IN-2

SOAT-IN-2 是一种选择性的钠依赖性有机阴离子转运体 (SOAT，SLC10A6) 抑制剂。SOAT-IN-2 可阻断 DHEAS (HY-113416) 的钠依赖性细胞摄取。SOAT-IN-2 可减少细胞内雌二醇合成、DHEA (HY-14650) 生成以及 DHEAS 刺激的癌细胞增殖，且不会诱导细胞毒性。SOAT-IN-2 可用于乳腺癌相关研究。

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SOAT-IN-2

SOAT-IN-2 Chemical Structure

CAS No. : 3056727-95-5

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SOAT-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SOAT-IN-2 is a selective sodium-dependent organic anion transporter (SOAT, SLC10A6) inhibitor. SOAT-IN-2 blocks sodium-dependent cellular uptake of sulfated steroid Dehydroepiandrosterone sulfate (DHEAS, HY-113416). SOAT-IN-2 reduces intracellular estradiol synthesis, DHEA (HY-14650) formation, and DHEAS-stimulated cancer cell proliferation without inducing cytotoxicity. SOAT-IN-2 can be used for the research of breast cancer[1].

体外研究
(In Vitro)

SOAT-IN-2 (compound 12) (10 μM；5 分钟预孵育) 可强效抑制 MCF-7_SOAT 细胞中钠依赖性 SOAT 介导的[3H]DHEAS 摄取[1]。
SOAT-IN-2 (10 μM；10 分钟预孵育) 可完全抑制 MCF-7_SOAT 细胞中由 DHEAS 刺激的增殖[1]。
SOAT-IN-2 (10 μM；30 分钟预孵育) 可显著降低 MCF-7_SOAT 细胞中由 DHEAS 生成的 DHEA 和雌二醇的含量[1]。
SOAT-IN-2 可抑制 SOAT 转染 HEK293 细胞中 SOAT 介导的 DHEAS 转运，其 IC50 为 1.9 μM[1]。
SOAT-IN-2 (0.1-10 μM；24 小时) 对MCF-7_FRT 和 MCF-7_SOAT 细胞无细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SOAT-IN-2 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT)
Concentration: 10 μM
Incubation Time: 10 min
Result: Had no effect on MCF-7_SOAT cell proliferation.

Cell Proliferation Assay[1]

Cell Line: SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT)
Concentration: 10 μM plus 10 μM DEHA
Incubation Time: 3 days
Result: Completely abolished the DHEAS-stimulated proliferation of MCF-7_SOAT cells, reducing proliferation to baseline control levels when combined with DHEAS.

Cell Cytotoxicity Assay[1]

Cell Line: SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT), control MCF-7_FRT cells
Concentration: 0.1 μM; 10 μM
Incubation Time: 24 h
Result: Did not induce LDH release in either MCF-7_FRT or MCF-7_SOAT cells, indicating no cytotoxicity under these conditions.
分子量

500.74

Formula

C19H12Cl3N3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SOAT-IN-2 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

SOAT-IN-23056727-95-5Na+/HCO3- CotransporterNa/HCO3 cotransporterNBCHEK293 cellssodium-dependent organic anion transporterSLC10A6MCF-7_SOAT cellsbreast cancerestradiolDHEASdehydroepiandrosterone sulfateSOATDHEAInhibitorinhibitorinhibit

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