2. Membrane Transporter/Ion Channel
  3. OAT
  4. SOAT-IN-3

SOAT-IN-3 是一种选择性的钠依赖性有机阴离子转运体 (SOAT/SLC10A6) 抑制剂。SOAT-IN-3 可减少细胞内雌二醇合成、由 DHEAS 生成脱氢表雄酮 (DHEA) 的过程，以及 DHEAS 诱导的癌细胞增殖。SOAT-IN-3 在测试浓度下对乳腺癌细胞无细胞毒性。SOAT-IN-3 可用于乳腺癌的研究。

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SOAT-IN-3

SOAT-IN-3 Chemical Structure

CAS No. : 3056728-00-5

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SOAT-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SOAT-IN-3 is a selective inhibitor of sodium-dependent organic anion transporter (SOAT/SLC10A6). SOAT-IN-3 reduces intracellular estradiol synthesis, the process of dehydroepiandrosterone (DHEA) production from DHEAS, and DHEAS-induced cancer cell proliferation. SOAT-IN-3 shows no cytotoxicity against breast cancer cells at the tested concentrations. SOAT-IN-3 can be used in the research of breast cancer[1].

体外研究
(In Vitro)

SOAT-IN-3 (compound 24) (10 μM; 5 min preincubation) 可强效抑制 MCF-7_SOAT 乳腺癌细胞中钠依赖性 SOAT 介导的[3H]DHEAS 摄取[1]。
SOAT-IN-3 (10 μM; 10 min preincubatio) 可完全抑制 MCF-7_SOAT 乳腺癌细胞中由 DHEAS 诱导的增殖，单独使用时未观察到细胞毒性作用[1]。
SOAT-IN-3 (10 μM; 10 min preincubation) 可显著降低 MCF-7_SOAT 乳腺癌细胞中由 DHEAS 生成的 DHEA 和雌二醇的含量[1]。
SOAT-IN-3 可强效抑制 SOAT 转染 HEK293 细胞中 SOAT 介导的 DHEAS 转运，其 IC50 为 0.6 μM[1]。
SOAT-IN-3 (0.1-10 μM; 24 h) 在 MCF-7SOAT 或 MCF-7FRT 乳腺癌细胞中无细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SOAT-IN-3 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT), control MCF-7_FRT cells
Concentration: 0.1-10 μM
Incubation Time: 24 h
Result: Did not induce LDH release in either MCF-7_SOAT or MCF-7_FRT cells, indicating no cytotoxicity at these concentrations.
分子量

472.32

Formula

C17H11Cl2N3O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SOAT-IN-3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOAT-IN-33056728-00-5OATOrganic anion transporterestradiolMCF-7_SOATbreast cancer cellssodium-dependent organic anion transporterSOATDHEAdehydroepiandrosterone sulfateDHEASSLC10A6HEK293 cellsInhibitorinhibitorinhibit

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