2. PROTAC
  3. Molecular Glues
  4. TNG961

TNG961 是一种选择性口服活性 HBS1L 分子胶 (molecular glue) 降解剂。TNG961 可降低 HBS1L 蛋白水平，从而破坏参与核糖体拯救的 PELO 区域。TNG961 可用于研究 FOCAD 缺陷型癌症，例如胰腺癌。

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TNG961

TNG961 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货
1 mg ￥4160
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5 mg 询价 询问价格 & 货期
10 mg 询价 询问价格 & 货期
25 mg 询价 询问价格 & 货期

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Customer Review

TNG961 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNG961 is a selective and orally active molecular glue degrader of HBS1L. TNG961 can reduce HBS1L protein levels, thereby disrupting the PELO region involved in ribosome rescue. TNG961 can be used for the study of FOCAD-deficient cancers, such as pancreatic cancer[1].

体外研究
(In Vitro)

体外实验表明，TNG961 可导致 HBS1L 蛋白水平呈剂量依赖性下降，进而破坏参与核糖体拯救的 PELO 部分。TNG961 对 HBS1L 具有全蛋白质组选择性，Western blot 检测显示 SALL4 蛋白水平无变化。TNG961 诱导的 HBS1L 降解和 PELO 不稳定均可通过 CRBN 失活来逆转，证实了其作用机制[1]。
在基因工程改造的 HiBiT 敲入细胞中，TNG961 处理可在 4 小时内诱导 HBS1L 最大程度降解，且不影响 GSPT1 蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TNG961 相关抗体:
体内研究
(In Vivo)

TNG961 (口服) 在 FOCAD 缺失的异种移植模型中，可剂量依赖性地降解 HBS1L，并导致 PELO 蛋白不稳定，从而在多个谱系中引起肿瘤停滞或消退[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

539.57

Formula

C28H24F3N3O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNG961 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNG961TNG 961TNG-961Molecular GluesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-183115
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