2. Stem Cell/Wnt Apoptosis
  3. Wnt c-Myc Apoptosis
  4. TNIK-IN-10

TNIK-IN-10 (Compound N15) 是一种 TNIK 抑制剂，对人源 TNIK 的 IC50 为 0.49 nM。TNIK-IN-10 可抑制 TNIK 的酶活性，下调 Wnt 通路靶基因 c-Myc 和 AXIN2 的表达，下调 LRP5 和 LRP6 蛋白表达。TNIK-IN-10 诱导凋亡 (Apoptosis)。TNIK-IN-10 对结直肠癌具有抗癌活性。TNIK-IN-10 可用于结直肠癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

TNIK-IN-10

TNIK-IN-10 Chemical Structure

CAS No. : 3112758-72-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

TNIK-IN-10 相关抗体

Top Publications Citing Use of Products

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNIK-IN-10 (Compound N15) is a TNIK inhibitor with an IC50 of 0.49 nM against human TNIK. TNIK-IN-10 inhibits the enzymatic activity of TNIK, downregulates the expression of Wnt pathway target genes c-Myc and AXIN2, and reduces the protein expression of LRP5 and LRP6. TNIK-IN-10 induces apoptosis. TNIK-IN-10 exhibits anticancer activity against colorectal cancer. TNIK-IN-10 can be used in the research of colorectal cancer[1].

体外研究
(In Vitro)

TNIK-IN-10 (60 min) 可强效抑制重组人 TNIK 酶活性，其 IC50 为 0.49 nM[1]。
TNIK-IN-10 在人肝微粒体中表现出较高的代谢稳定性，半衰期为 241 min[1]。
TNIK-IN-10 (72 h) 可强效抑制结直肠癌细胞 HCT116 的增殖，其 IC50 为 2.24 ± 0.87 μM[1]。
TNIK-IN-10 (1.9-7.5 μM; 72 h) 可呈剂量依赖性诱导结直肠癌细胞 HCT116 发生细胞凋亡[1]。
TNIK-IN-10 (1.9-7.5 μM; 72 h) 可改变 HCT116 人结直肠癌细胞的细胞周期进程，经 72 h 处理后会降低 G1 期细胞占比并增加 S 期细胞占比[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TNIK-IN-10 相关抗体:

Western Blot Analysis[1]

Cell Line: HCT116 human colorectal cancer cells
Concentration: 1.9-15 μM
Incubation Time: 48 h
Result: Reduced protein expression of Wnt target genes c-Myc and AXIN2, and downregulated LRP5 and LRP6 protein levels in a dose-dependent manner; TNIK protein expression remained unchanged.
体内研究
(In Vivo)

TNIK-IN-10 (30-50 mg/kg；腹腔注射；给 5 天/停 2 天，持续 16 天) 可在 BALB/c 裸鼠中强效且呈剂量依赖性地抑制 HCT116 异种移植瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (male, 6 weeks old, 19-22 g, subcutaneous xenograft)[1]
Dosage: 30 mg/kg; 50 mg/kg
Administration: i.p.; 5-days-on/2-days-off; 16 days
Result: Achieved a tumor growth inhibition (TGI) rate of 69.6% at 50 mg/kg.
Markedly reduced tumor weights in both 30 mg/kg and 50 mg/kg treatment groups.
Induced transient body weight reductions early in treatment, which subsequently stabilized.
分子量

465.55

Formula

C28H27N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNIK-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNIK-IN-103112758-72-9Wntc-MycApoptosisMyccolorectal cancerHCT116 human colorectal cancer cellsBALB/c nude miceAXIN2Wnt/β-catenin pathwaycell cycle arrestapoptosisTNIKhuman liver microsomesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TNIK-IN-10
目录号：
HY-181930
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z