2. Cell Cycle/DNA Damage Epigenetics Stem Cell/Wnt
  3. PARP Wnt β-catenin
  4. TNKS-IN-1

TNKS-IN-1 是一种选择性强效的端锚聚合酶 (TNKS1/TNKS2) 抑制剂，其 IC50 值分别为 7.9 nM 和 8.7 nM。TNKS-IN-1 可诱导 axin2 积累，对应的 EC50 为 1500 nM。TNKS-IN-1 可通过稳定轴蛋白 (axin) 并促进 β-catenin 降解来拮抗 Wnt 信号转导通路。TNKS-IN-1 可用于结直肠癌的相关研究。

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TNKS-IN-1

TNKS-IN-1 Chemical Structure

CAS No. : 59455-93-5

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TNKS-IN-1 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNKS-IN-1 is a selective and potent tankyrase (TNKS1/TNKS2) inhibitor with IC50 values of 7.9 nM and 8.7 nM. TNKS-IN-1 induces axin2 accumulation with an EC50 of 1500 nM. TNKS-IN-1 can antagonize the Wnt signal transduction pathway by stabilizing axin proteins and promoting β-catenin degradation. TNKS-IN-1 can be used for the research of colorectal cancer[1].

IC50 & Target[1]

TNKS1

7.9 nM (IC50)

TNKS2

8.7 nM (IC50)

PARP-1

>10000 nM (IC50)

体外研究
(In Vitro)

TNKS-IN-1 (Compound 3a) (1 h) 可强效抑制纯化的人源 TNKS1 和 TNKS2，其 IC50 值分别为 7.9 nM 和 8.7 nM，且对 PARP1 的 IC50 超过 10000 nM[1]。
TNKS-IN-1 (24 h) 可诱导 DLD1 细胞中 axin2 的积累，其 EC50 为 1500 nM，证实了其细胞内端锚聚合酶抑制活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TNKS-IN-1 相关抗体:
分子量

278.36

Formula

C18H18N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNKS-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNKS-IN-159455-93-5PARPWntβ-cateninpoly ADP ribose polymerase Beta cateninPARP1mouse liver microsomescolorectal cancertankyrasehuman liver microsomesTNKS1TNKS2axin2DLD1 cellsInhibitorinhibitorinhibit

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目录号：
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