2. Immunology/Inflammation
  3. Interleukin Related
  4. TPP-9476

TPP-9476 是一种抗人源 IL3RA (CD123)单克隆抗体，与人源 IL3RA 的 Kd 为 11 nM，与食蟹猴 IL3RA 的 Kd 为 16 nM。TPP-9476 可特异性结合人源和食蟹猴的 IL3RA，并以靶点依赖的方式内化至 IL3RA 阳性细胞的溶酶体中。TPP-9476 可在表达 IL3RA 的急性髓系白血病细胞和经典型霍奇金淋巴瘤细胞中发挥抗增殖作用，在相关异种移植小鼠模型中可降低肿瘤负荷、改善生存情况并诱导肿瘤完全缓解。

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TPP-9476

TPP-9476 Chemical Structure

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TPP-9476 相关抗体

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查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TPP-9476 is an anti-human IL3RA (CD123) monoclonal antibody with human IL3RA Kd of 11 nM and cynomolgus monkey IL3RA Kd of 16 nM. TPP-9476 binds specifically to human and cynomolgus monkey IL3RA, undergoes target-dependent internalization into lysosomes of IL3RA-positive cells.TPP-9476 exerts antiproliferative effects in IL3RA-expressing acute myeloid leukemia and classical Hodgkin lymphoma cells, reduces tumor burden, improves survival, and induces complete tumor remission in relevant xenograft mouse models[1].

反应种属

Human
体外研究
(In Vitro)

TPP-9476 (靶向 IL3RA 的抗体) (titrated log M values) 以高亲和力结合重组人及食蟹猴 IL3RA 蛋白，且可与 IL3RA 阳性的人急性髓系白血病细胞系 MV-4-11、MOLM-13 和 KG-1 发生特异性的、剂量依赖性结合，而不结合小鼠 IL3RA[1]。
TPP-9476 (靶向 IL3RA 的抗体) (10-20 μg/mL; 0-6 h) 可被 IL3RA 阳性的 MOLM-13 和 MV-4-11 急性髓系白血病细胞特异性、时间依赖性地内吞，并且在 MOLM-13 细胞中与溶酶体共定位，但在 IL3RA 阴性的 HBL-1 细胞中无此现象[1]。
TPP-9476 (靶向 IL3RA 的抗体) (up to 3.00 × 10-7 M; 72 h) 单独使用时，在 IL3RA 阳性的人急性髓系白血病和霍奇金淋巴瘤细胞系中无抗增殖活性，即使在孵育 72 h 后浓度高达 3.00 × 10-7 M 时也是如此[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TPP-9476 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MV-4-11, MOLM-13, HDLM-2, THP-1, NCI-H292
Concentration: Up to 3.00 × 10-7 M
Incubation Time: 72 h
Result: Showed no antiproliferative activity (IC50 > 3.00 × 10-7 M) in IL3RA-positive MV-4-11, MOLM-13, HDLM-2, THP-1, and IL3RA-low NCI-H292 cell lines.
体内研究
(In Vivo)

TPP-9476 (5 mg/kg, once every 7 days, twice) 在 MV-4-11 模型中未表现出肿瘤生长抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

3563  [NCBI]

Accession
靶点

IL-3Ra/CD123
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TPP-9476 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPP-9476BAY-943 antibodyTPP9476TPP 9476Interleukin RelatedILMV-4-11cynomolgus monkeyratsKG-1MOLM-13acute myeloid leukemialysosomesclassical Hodgkin lymphomaxenograft mouse modelsIL3RAInhibitorinhibitorinhibit

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产品名称：
TPP-9476
目录号：
HY-P992032
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