2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. (-)-UH 232

(-)-UH 232 是中枢多巴胺 (DA) 受体激动剂。(-)-UH 232 轻度降低大鼠纹状体和边缘脑区的 3,4-二羟基苯丙氨酸 (DOPA) 生成。(-)-UH 232 可用于帕金森病和精神分裂症等神经系统疾病的研究。

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(-)-UH 232

(-)-UH 232 Chemical Structure

CAS No. : 95999-11-4

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(-)-UH 232 相关抗体

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  • 生物活性

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生物活性

(-)-UH 232 is a central dopamine (DA) receptor agonist. (-)-UH 232 weakly decreases 3, 4-dihydroxyphenylalanine (DOPA) formation in striatal and limbic brain regions in rats. (-)-UH 232 can be used for the research of neurological diseases including parkinson's disease and schizophrenia[1].

体内研究
(In Vivo)

(-)-UH 232 (0.8-204 μmol/kg；皮下注射；单次给药) 在大鼠中表现为一种弱效中枢多巴胺受体激动剂，其作用表现为纹状体和边缘系统 DOPA 生成的适度降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (male, 200-300 g)[1]
Dosage: 0.8, 3.2, 13, 52, 204 μmol/kg
Administration: s.c.; single dose
Result: Failed to significantly influence locomotor activity in non-pretreated rats at doses up to 52 μmol/kg.
Did not antagonize Reserpine (HY-N0480)-induced hypomotility at 204 μmol/kg.
Produced a weak trend towards reduced cortical DOPA formation, with a significant 15% decrease only at 52 μmol/kg in non-pretreated rats.
Dose-dependently decreased DOPA formation in limbic and striatal regions of reserpinized rats.
分子量

275.44

Formula

C18H29NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-UH 232 相关分类

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Keywords:

(-)-UH 23295999-11-4Dopamine Receptornon-pretreated ratsparkinson's diseasereserpine-induced akinesiaschizophrenianeurological diseasesdopamine receptor modulation modelsstriatumbrain regionsSprague-Dawley ratsreserpinized ratsDOPA formationdopamine (DA) receptor agonistlimbic regionInhibitorinhibitorinhibit

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