1. Cell Cycle/DNA Damage Cytoskeleton Anti-infection
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  3. Wikstrol B

Wikstrol B (compound 5) 是一种双黄酮类微管蛋白 (Microtubule/Tubulin) 抑制剂和 HIV-1 抑制剂。Wikstrol B 对微管聚合的 IC50 值为 184 μM,对 HIV-1EC50 可达 3.02 μM,作用于 HIV-1 复制早期事件。Wikstrol B 通过诱导 Pyricularia oryzae (稻瘟病菌) 菌丝形态变形发挥抗真菌活性,并通过抑制微管聚合发挥抗有丝分裂活性。Wikstrol B 可用于抗真菌、抗肿瘤及抗艾滋病相关领域的研究。Wikstrol B 能够从 Wikstroemia indica (瑞香狼毒) 的根中天然提取得到。

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Wikstrol B

Wikstrol B Chemical Structure

CAS No. : 160963-92-8

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生物活性

Wikstrol B (compound 5) is a biflavonoid microtubule/tubulin inhibitor and HIV-1 inhibitor. Wikstrol B has an IC50 value of 184 μM for microtubule polymerization and an EC50 of 3.02 μM against HIV-1, acting on early events of HIV-1 replication. Wikstrol B exerts antifungal activity by inducing morphological deformation of Pyricularia oryzae hyphae and exerts anti-mitotic activity by inhibiting microtubule polymerization. Wikstrol B can be used in research related to antifungal, antitumor, and anti-AIDS applications. Wikstrol B can be naturally extracted from the roots of Wikstroemia indica[1].

IC50 & Target

HIV-1

 

分子量

542.49

Formula

C30H22O10

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Wikstrol B
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HY-N16760
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