2. Cell Cycle/DNA Damage
  3. Wee1 CDK
  4. XL495

XL495 是一种强效、选择性且口服活性的 PKMYT1 抑制剂。XL495 可在功能上阻断 PKMYT1 的活性，抑制异种移植肿瘤中 CDK1 的 Thr14 磷酸化，并诱导 KAP1 的 Ser824 磷酸化。XL495 可降低结直肠癌和乳腺癌异种移植模型中的肿瘤生长，且在结直肠癌异种移植模型中与 DNA 损伤剂联用可实现肿瘤消退。XL495 可用于癌症相关研究，例如乳腺癌和结直肠癌。

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XL495

XL495 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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100 mg   询价  
250 mg   询价  

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Customer Review

XL495 相关抗体

Top Publications Citing Use of Products

查看 Wee1 亚型特异性产品:

查看所有亚型
PKMYT1

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XL495 is an potent, selective and orally active PKMYT1 inhibitor. XL495 functionally blocks PKMYT1 activity, inhibiting CDK1 Thr14 phosphorylation and induces KAP1 Ser824 phosphorylation in xenograft tumors. XL495 reduces tumor growth in colorectal and breast cancer xenograft models, and achieves tumor regression with DNA-damaging agents in colorectal cancer xenograft models. XL495 can be used for the research of cancer, such as breast cancer and colorectal cancer[1][2].

IC50 & Target[1]

PKMYT1

 

CDK1

 

体内研究
(In Vivo)

XL495 (口服) 在乳腺癌细胞系来源异种移植 (CDX) 模型中显示出抗肿瘤活性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

308.33

Formula

C17H16N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

XL495 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XL495XL 495XL-495Wee1CDKCyclin dependent kinaseCaco-2 cellsPKMYT1lung canceradvanced solid tumorsCDK1 Thr14 phosphorylationKAP1 Ser824 phosphorylationxenograft tumorsovarian cancercolorectal cancerbreast cancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-182906
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