80-09-1 (4,4-二羟基二苯砜,4,4&#x27;-Sulfonyldiphenol)

_99%

反应条件：

1.1 Reagents: 1,3-Benzenedisulfonic acid , Sulfuric acid Solvents: Mesitylene

参考文献：

Preparation of highly pure 4,4'-dihydroxydiphenyl sulfone.

, Japan, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen peroxide Catalysts: 2732900-19-3 (bonded to Fe3O4) Solvents: Acetonitrile ; 440 min, 35 °C

参考文献：

Schiff base complex of Mo supported on iron oxide magnetic nanoparticles (Fe3O4) as recoverable nanocatalyst for the selective oxidation of sulfides

Aghajani, Milad; et al, Journal of the Iranian Chemical Society, 2017, 14(5), 963-975

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Hydrogen peroxide Catalysts: Bis(acetylacetonato)dioxomolybdenum (supported on imine-functionalized zeolite H-beta) ; 50 min, rt

参考文献：

Efficient molybdenum catalyzed chemoselective, solvent-free oxidation of sulfides to sulfones at room temperature

Hadigavabar, Ali Dadashi; et al, Journal of the Chilean Chemical Society, 2018, 63(1), 3829-3833

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Water , N-Fluorobenzenesulfonimide ; 24 h, rt

参考文献：

Selective synthesis of sulfoxides and sulfones via controllable oxidation of sulfides with N-fluorobenzenesulfonimide

Xu, Xiaobo; et al, Organic & Biomolecular Chemistry, 2021, 19(40), 8691-8695

合成路线：1 步

98-67-9

_97%

反应条件：

1.1 Solvents: Isopropanol , Isoamyl alcohol ; 1 h, 60 °C

参考文献：

Study on water removal control in synthesis and purification of bisphenol S

Zhang, Tianyong; et al, Huaxue Tongbao, 2016, 79(3), 259-263

合成路线：1 步

98-67-9

_85%

反应条件：

1.1 Reagents: Sulfuric acid

参考文献：

Synthesis of some esters of 4,4'-dihydroxydiphenyl sulfone and carboxylic acids

Baranov, S. N.; et al, Zhurnal Obshchei Khimii, 1958, 28, 1274-6

合成路线：1 步

98-48-6

_96%

参考文献：

Highly pure 4,4'-dihydroxydiphenyl sulfone

, World Intellectual Property Organization, , ,

合成路线：1 步

25667-42-9

_92%

反应条件：

1.1 Reagents: 1,3-Dimethyl-2-imidazolidinone , Cesium hydroxide ; 4 h, 150 °C; 150 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Hydroxylation-Depolymerization of Oxyphenylene-Based Super Engineering Plastics To Regenerate Arenols

Minami, Yasunori ; et al, JACS Au, 2023, 3(8), 2323-2332

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Triethylamine , Hexachlorocyclotriphosphazene Solvents: Acetone , Toluene ; 5 h, 40 °C

参考文献：

Studies of selective detection of picric acid in solution phase using fluorescent polyphosphazene nanofibers

Wei, Wei; et al, Gaofenzi Xuebao, 2015, (12), 1477-1485

合成路线：1 步

_84%

反应条件：

1.1 Reagents: Potassium bicarbonate , Sodium carbonate , Potassium carbonate Solvents: Water ; 126.76 min, 0 °C
1.2 16 h, 0 °C

参考文献：

Concentrated Aqueous Peroxodicarbonate: Efficient Electrosynthesis and Use as Oxidizer in Epoxidations, S-, and N-Oxidations

Seitz, Ann-Katrin; et al, Angewandte Chemie, 2022, 61(25),

合成路线：1 步

106-41-2

_83%

反应条件：

1.1 Reagents: Diisopropylethylamine , Potassium pyrosulfite Catalysts: Palladium diacetate , Tri-tert-butylphosphonium tetrafluoroborate Solvents: Dimethylformamide ; rt → 100 °C; 20 h, 100 °C

参考文献：

Palladium-catalyzed One-step Synthesis of Symmetrical Diaryl Sulfones from Aryl Halides and a Sulfur Dioxide Surrogate

Tanaka, Hiromichi; et al, Chemistry Letters, 2019, 48(8), 760-763

合成路线：1 步

540-38-5

_74%

反应条件：

1.1 Reagents: Diisopropylethylamine , Potassium pyrosulfite Catalysts: Palladium diacetate , Tri-tert-butylphosphonium tetrafluoroborate Solvents: Dimethylformamide ; rt → 100 °C; 20 h, 100 °C

参考文献：

Palladium-catalyzed One-step Synthesis of Symmetrical Diaryl Sulfones from Aryl Halides and a Sulfur Dioxide Surrogate

Tanaka, Hiromichi; et al, Chemistry Letters, 2019, 48(8), 760-763

合成路线：1 步

499121-93-6

37181-39-8

_35%

反应条件：

1.1 Reagents: Acetohydroxamic acid , Potassium carbonate Solvents: Dimethyl sulfoxide ; 20 min, rt
1.2 rt → 80 °C; 12 h, 80 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 3

参考文献：

Synthesis of Phenols from Aryl Ammonium Salts under Mild Conditions

Ni, Pufan; et al, Journal of Organic Chemistry, 2022, 87(19), 12677-12687

合成路线：2 步

33871-62-4

333-27-7

反应条件：

1.1 Solvents: Dichloromethane ; rt; overnight, rt
2.1 Reagents: Acetohydroxamic acid , Potassium carbonate Solvents: Dimethyl sulfoxide ; 20 min, rt
2.2 rt → 80 °C; 12 h, 80 °C
2.3 Reagents: Hydrochloric acid Solvents: Water ; pH 3

参考文献：

Synthesis of Phenols from Aryl Ammonium Salts under Mild Conditions

Ni, Pufan; et al, Journal of Organic Chemistry, 2022, 87(19), 12677-12687

合成路线：2 步

637-89-8

71597-85-8

反应条件：

1.1 Catalysts: 2,2′-Bipyridine , Nickel dichloride Solvents: Dimethylformamide , Acetonitrile ; 5 min, rt
1.2 Reagents: Potassium tert-butoxide ; rt; 12 h, rt
1.3 Reagents: Ammonium chloride Solvents: Water
2.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene , Hydrogen peroxide Catalysts: Zinc chloride Solvents: Methanol ; rt; 16 h, 80 °C

参考文献：

Room temperature nickel-catalyzed cross-coupling of aryl-boronic acids with thiophenols: synthesis of diarylsulfides

Bhowmik, Amit; et al, Organic & Biomolecular Chemistry, 2020, 18(13), 2447-2458

合成路线：3 步

37181-39-8

149-73-5

反应条件：

1.1 0 °C; 0 °C → rt; 30 min, rt
2.1 Solvents: Dichloromethane ; rt; overnight, rt
3.1 Reagents: Acetohydroxamic acid , Potassium carbonate Solvents: Dimethyl sulfoxide ; 20 min, rt
3.2 rt → 80 °C; 12 h, 80 °C
3.3 Reagents: Hydrochloric acid Solvents: Water ; pH 3

参考文献：

Synthesis of Phenols from Aryl Ammonium Salts under Mild Conditions

Ni, Pufan; et al, Journal of Organic Chemistry, 2022, 87(19), 12677-12687

合成路线：3 步

80-08-0

50-00-0

反应条件：

1.1 Reagents: Sodium cyanoborohydride Solvents: Acetic acid ; overnight, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; 30 min, 0 °C
2.1 Solvents: Dichloromethane ; rt; overnight, rt
3.1 Reagents: Acetohydroxamic acid , Potassium carbonate Solvents: Dimethyl sulfoxide ; 20 min, rt
3.2 rt → 80 °C; 12 h, 80 °C
3.3 Reagents: Hydrochloric acid Solvents: Water ; pH 3

参考文献：

Synthesis of Phenols from Aryl Ammonium Salts under Mild Conditions

Ni, Pufan; et al, Journal of Organic Chemistry, 2022, 87(19), 12677-12687

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Sodium periodate Catalysts: Imidazole , Silica , (SP-5-12)-Chloro[2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetraphenyl-21H,23H-po… Solvents: Acetonitrile , Water ; rt; 10 min, rt → 40 °C

参考文献：

Highly efficient oxidation of sulfides with sodium periodate catalyzed by reusable silica supported Mn(Br8TPP)Cl and Mn(TPP)Cl catalysts under various reaction conditions

Mirkhani, Valiollah; et al, Applied Catalysis, 2009, 353(1), 61-67

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Hydrogen peroxide Catalysts: Trifluoromethanesulfonic acid , Sodium tungsten oxide (Na2WO4) Solvents: Methanol ; 2 h, 30 °C

参考文献：

Sulfoxidation inside a hypercrosslinked microporous network nanotube catalyst

Shi, Zhaocheng; et al, New Journal of Chemistry, 2020, 44(4), 1542-1547

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Hydrogen peroxide Catalysts: 2732900-19-3 (bonded to Fe3O4) Solvents: Ethanol ; 570 min, rt

参考文献：

Schiff base complex of Mo supported on iron oxide magnetic nanoparticles (Fe3O4) as recoverable nanocatalyst for the selective oxidation of sulfides

Aghajani, Milad; et al, Journal of the Iranian Chemical Society, 2017, 14(5), 963-975

合成路线：1 步

25839-81-0

_87%

92-88-6

反应条件：

1.1 Reagents: 1,3-Dimethyl-2-imidazolidinone , Calcium hydride , Cesium hydroxide ; 19 h, 150 °C; 150 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Hydroxylation-Depolymerization of Oxyphenylene-Based Super Engineering Plastics To Regenerate Arenols

Minami, Yasunori ; et al, JACS Au, 2023, 3(8), 2323-2332

合成路线：1 步

_57%

5397-34-2

反应条件：

1.1 Reagents: Sulfuric acid , Phosphonic acid Solvents: 1,2,4-Trimethylbenzene

参考文献：

Liquid-crystal aromatic polyesters containing azo and sulfone units

Qiu, Ming Yan; et al, Asian Journal of Chemistry, 2014, 26(22), 7759-7762

合成路线：1 步

25667-42-9

_75%