823-86-9 (4-氯苯基羟胺,4-Chlorophenylhydroxylamine)

_98%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Ruthenium Solvents: Tetrahydrofuran ; 2.5 h, rt

参考文献：

Selective conversion of nitroarenes using a carbon nanotube-ruthenium nanohybrid

Jawale, Dhanaji V.; et al, Chemical Communications (Cambridge, 2015, 51(9), 1739-1742

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Platinum , Silica ; 1 h, 200 °C; 200 °C → rt
1.2 Reagents: Dimethyl sulfoxide , Hydrogen , (±)-sec-Butylamine Solvents: Isopropanol ; 100 min, 1 bar, rt

参考文献：

Selective synthesis of N-aryl hydroxylamines by the hydrogenation of nitroaromatics using supported platinum catalysts

Takenaka, Yasumasa; et al, Green Chemistry, 2009, 11(9), 1385-1390

合成路线：1 步

1303610-38-9

_88%

反应条件：

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ; 90 min, 40 °C
1.2 Solvents: Water ; pH 7

参考文献：

Synthesis of N-arylhydroxylamines by Pd-catalyzed coupling

Beaudoin, Daniel; et al, Tetrahedron Letters, 2011, 52(17), 2221-2223

合成路线：1 步

反应条件：

1.1 Catalysts: Chloroperoxidase

参考文献：

The action of chloride peroxidase on 4-chloroaniline. N-oxidation and ring halogenation

Corbett, Michael D.; et al, Biochemical Journal, 1980, 187(3), 893-903

合成路线：1 步

116278-63-8

反应条件：

1.1 Reagents: Potassium chloride , Water Solvents: Acetonitrile , Water

参考文献：

Nucleophilic substitution at nitrogen and carboxyl carbon of N-aryl-O-pivaloylhydroxylamines in aqueous solution: competition with SN1 solvolysis of model carcinogens

Helmick, John S.; et al, Journal of Organic Chemistry, 1991, 56(8), 2925-7

合成路线：1 步

98-95-3

反应条件：

1.1 Reagents: Zinc

参考文献：

Synthesis and characterization of normal and N-substituted octanohydroxamic acid complexes

BenGuzzi, Salima A.; et al, Chemica Sinica, 2014, 5(3), 47-50

合成路线：2 步

1303610-35-6

106-39-8

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: Tris(dibenzylideneacetone)dipalladium , 5-[Bis(1,1-dimethylethyl)phosphino]-1′,3′,5′-triphenyl-1,4′-bi-1H-pyrazole Solvents: Toluene ; 30 min, rt; 16 h, 80 °C
2.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ; 90 min, 40 °C
2.2 Solvents: Water ; pH 7

参考文献：

Synthesis of N-arylhydroxylamines by Pd-catalyzed coupling

Beaudoin, Daniel; et al, Tetrahedron Letters, 2011, 52(17), 2221-2223

合成路线：3 步

134262-94-5

18162-48-6

反应条件：

1.1 Reagents: Triethylamine
2.1 Reagents: Cesium carbonate Catalysts: Tris(dibenzylideneacetone)dipalladium , 5-[Bis(1,1-dimethylethyl)phosphino]-1′,3′,5′-triphenyl-1,4′-bi-1H-pyrazole Solvents: Toluene ; 30 min, rt; 16 h, 80 °C
3.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ; 90 min, 40 °C
3.2 Solvents: Water ; pH 7

参考文献：

Synthesis of N-arylhydroxylamines by Pd-catalyzed coupling

Beaudoin, Daniel; et al, Tetrahedron Letters, 2011, 52(17), 2221-2223

合成路线：4 步

2916-68-9

530-62-1

反应条件：

1.1 Reagents: Hydroxylamine
2.1 Reagents: Triethylamine
3.1 Reagents: Cesium carbonate Catalysts: Tris(dibenzylideneacetone)dipalladium , 5-[Bis(1,1-dimethylethyl)phosphino]-1′,3′,5′-triphenyl-1,4′-bi-1H-pyrazole Solvents: Toluene ; 30 min, rt; 16 h, 80 °C
4.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ; 90 min, 40 °C
4.2 Solvents: Water ; pH 7

参考文献：

Synthesis of N-arylhydroxylamines by Pd-catalyzed coupling

Beaudoin, Daniel; et al, Tetrahedron Letters, 2011, 52(17), 2221-2223

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Ruthenium , 1H-Imidazolium, 1,3-bis[(4-ethenylphenyl)methyl]-2-methyl-, chloride (1:1), poly… Solvents: Ethanol ; 180 min, 25 °C

参考文献：

Highly efficient and selective partial reduction of nitroarenes to N-arylhydroxylamines catalysed by phosphine oxide-decorated polymer immobilized ionic liquid stabilized ruthenium nanoparticles

Paterson, Reece; et al, Journal of Catalysis, 2023, 417, 74-88

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Methylhydrazine Solvents: Acetonitrile ; 3 h, 28 °C

参考文献：

Selective Photoinduced Reduction of Nitroarenes to N-Arylhydroxylamines

Kallitsakis, Michael G.; et al, Organic Letters, 2020, 22(11), 4339-4343

合成路线：1 步

_83%