836-41-9 (N-(4-甲氧亚苄基)苯胺,1-(4-methoxyphenyl)-N-phenyl-methanimine)

_100%

反应条件：

1.1 Catalysts: Manganese zirconium oxide Solvents: Toluene ; 3 h, 1 atm, 80 °C

参考文献：

Efficient imine synthesis via oxidative coupling of alcohols with amines in an air atmosphere using a mesoporous manganese-zirconium solid solution catalyst

Wu, Shipeng; et al, Catalysis Science & Technology, 2021, 11(3), 810-822

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Oxygen Catalysts: Gold alloy, base, Au 65,Pd 35 (nanoparticles, zirconia-supported) Solvents: Ethanol ; 9 h, 40 °C
1.2 1 h, 40 °C

参考文献：

Au-Pd alloy nanoparticle catalyzed selective oxidation of benzyl alcohol and tandem synthesis of imines at ambient conditions

Cui, Wenjing ; et al, Catalysis Today, 2014, 235, 152-159

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: Cobalt (composite with carbon and nitrogen; carbon nanotube encapsulated) ; 20 h, 160 °C

参考文献：

Direct reductive coupling of nitroarenes and alcohols catalysed by Co-N-C/CNT@AC

Liu, Di; et al, Green Chemistry, 2019, 21(8), 2129-2137

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Cobalt Solvents: Octane ; 12 h, 0.6 MPa, 140 °C

参考文献：

Preparation of Co-N-C catalysts and "one-pot method" for synthesis of N-benzyl aniline

Leng, Jie; et al, Huagong Xuebao (Chinese Edition), 2020, 71(11), 5016-5024

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: 1-Butanaminium, N,N,N-tributyl-, stereoisomer of diaqua[μ10-[orthosilicato(4-)-κ… Solvents: Acetonitrile , Toluene ; 4 h, 60 °C; 2 h, 100 °C

参考文献：

Visible-Light-Responsive Multielectron Redox Catalysis of Lacunary Polyoxometalates Induced by Substrate Coordination to Their Lacuna

Suzuki, Kosuke; et al, Chemistry - An Asian Journal, 2015, 10(1), 144-148

合成路线：1 步

_100%

反应条件：

1.1 Solvents: Benzene ; 4 h, reflux

参考文献：

Applications of dynamic combinatorial chemistry for the determination of effective molarity

Ciaccia, Maria; et al, Chemical Science, 2015, 6(1), 144-151

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Copper , Silica Solvents: Toluene ; 0.5 h, 1 atm, 100 °C

参考文献：

Reductive Amination of Ketones or Amination of Alcohols over Heterogeneous Cu Catalysts: Matching the Catalyst Support with the N-Alkylating Agent

Santoro, Federica; et al, ChemCatChem, 2012, 4(9), 1249-1254

合成路线：1 步

_100%

反应条件：

1.1 2 - 2.1 kPa, 80 °C

参考文献：

Alkoxy substituted (E,E)-3,6-bis(styryl)pyridazine-a photosensitive mesogen for liquid crystals

Lifka, Thorsten; et al, Tetrahedron, 2008, 64(27), 6551-6560

合成路线：1 步

857402-61-0

_99%

反应条件：

1.1 Solvents: Benzene-d6 ; 1 h, 25 °C

参考文献：

Readily Available Primary Aminoboranes as Powerful Reagents for Aldimine Synthesis

Junor, Glen P. ; et al, Angewandte Chemie, 2019, 58(9), 2875-2878

合成路线：1 步

857402-61-0

反应条件：

1.1 Solvents: Benzene-d6 ; 0.5 h, rt

参考文献：

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

Gudun, Kristina A.; et al, Advanced Synthesis & Catalysis, 2022, 364(3), 601-611

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Pinacolborane Catalysts: Cobalt(II) acetylacetonate , Bis[2-(diphenylphosphino)phenyl] ether Solvents: Benzene-d6 ; 1 h, rt
1.2 Solvents: Benzene-d6 ; 0.5 h, rt

参考文献：

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

Gudun, Kristina A.; et al, Advanced Synthesis & Catalysis, 2022, 364(3), 601-611

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Carbon monoxide , Water Catalysts: Gold , Titania Solvents: Triethylamine ; 1 h, 5 atm, 25 °C

参考文献：

Direct one-pot reductive imination of nitroarenes using aldehydes and carbon monoxide by titania supported gold nanoparticles at room temperature

Huang, Jun; et al, Green Chemistry, 2011, 13(10), 2672-2677

合成路线：1 步

_90%

反应条件：

1.1 Catalysts: Cobalt , Carbon nitride (C3N4) Solvents: Ethanol , Formic acid ; 12 h, 70 °C

参考文献：

Cobalt-Doped g-C3N4 Nanosheets for One-Pot Synthesis of Imines under Mild Conditions

Zhu, Jiukang; et al, ACS Applied Nano Materials, 2023, 6(7), 5127-5135

合成路线：1 步

2393-23-9

_99%

反应条件：

1.1 Reagents: Oxygen Catalysts: Ferrous bromide ; 6 h, 110 °C

参考文献：

A Solvent-Free Process for Synthesis of Imines by Iron-Catalyzed Oxidative Self- or Cross-Condensation of Primary Amines Using Molecular Oxygen as Sole Oxidant

Gopalaiah, Kovuru; et al, Catalysis Letters, 2016, 146(9), 1648-1654

合成路线：1 步

2393-23-9

_87%

反应条件：

1.1 Catalysts: (SP-5-52)-Carbonylhydro[[N,N′-(2,6-pyridinediyl-κN)bis[P,P-bis(1,1-dimethylethyl… ; 160 °C

参考文献：

Enhanced Reactivities toward Amines by Introducing an Imine Arm to the Pincer Ligand: Direct Coupling of Two Amines To Form an Imine Without Oxidant

He, Li-Peng; et al, Organometallics, 2012, 31(14), 5208-5211

合成路线：1 步

2393-23-9

_84%

反应条件：

1.1 Reagents: tert-Butyl hydroperoxide Catalysts: Chitosan (Cu/chitosan bead complex) Solvents: Acetonitrile ; 24 h, 80 °C

参考文献：

Uniform Cu/chitosan beads as a green and reusable catalyst for facile synthesis of imines via oxidative coupling reaction

Chutimasakul, Threeraphat; et al, RSC Advances, 2020, 10(35), 21009-21018

合成路线：1 步

3526-43-0

_99%

反应条件：

1.1 Reagents: 1,5-Diazabicyclo[4.3.0]non-5-ene Catalysts: Carbon dioxide , Eosin Solvents: Dimethyl sulfoxide ; 48 h, 1 atm, 25 - 30 °C

参考文献：

CO2-Catalyzed Efficient Dehydrogenation of Amines with Detailed Mechanistic and Kinetic Studies

Riemer, Daniel; et al, ACS Catalysis, 2018, 8(12), 11679-11687

合成路线：1 步

3526-43-0

_99%

反应条件：

1.1 Reagents: Sodium borohydride Catalysts: Chloro(triphenylphosphine)gold , 3,6,9,12-Tetraoxatridecan-1-ol, 13-(4-ethenylphenyl)-, polymer with ethenylbenze… Solvents: Tetrahydrofuran , Diglyme ; rt; 3 h, rt
1.2 Solvents: Mesitylene ; 5 h, 150 °C
1.3 Reagents: Oxygen Solvents: Toluene ; 20 h, 100 °C

参考文献：

Aerobic oxidation of amines catalyzed by polymer-incarcerated Au nanoclusters: effect of cluster size and cooperative functional groups in the polymer

Miyamura, Hiroyuki; et al, Bulletin of the Chemical Society of Japan, 2011, 84(6), 588-599

合成路线：1 步

3526-43-0

_97%

反应条件：

1.1 Reagents: Oxygen Catalysts: Gold , Graphite Solvents: Toluene ; 24 h, 110 °C

参考文献：

Graphite-Supported Gold Nanoparticles as Efficient Catalyst for Aerobic Oxidation of Benzylic Amines to Imines and N-Substituted 1,2,3,4-Tetrahydroisoquinolines to Amides: Synthetic Applications and Mechanistic Study

So, Man-Ho; et al, Chemistry - An Asian Journal, 2009, 4(10), 1551-1561

合成路线：1 步

64-10-8

_94%

反应条件：

1.1 Reagents: Potassium hydroxide , Oxygen ; 24 h, 135 °C

参考文献：

Base-mediated synthesis of imines and amines from N-phenylureas and alcohols

Yadav, Dilip Kumar T.; et al, Synlett, 2014, 25(11), 1611-1615

合成路线：1 步

3585-93-1

_93%

反应条件：

1.1 Reagents: Indium , Ammonium chloride Solvents: Methanol

参考文献：

Indium-mediated deoxygenation of nitrones, N-oxides and deoxygenative reductive coupling of nitrones to vicinal diamines

Jeevanandam, Arumugasamy; et al, Synthetic Communications, 2000, 30(17), 3153-3160

合成路线：1 步

3585-93-1

_90%

反应条件：

1.1 Reagents: Indium trichloride Solvents: Acetonitrile

参考文献：

An indium mediated efficient chemoselective deoxygenation of N-oxides and nitrones

Ilias, Md.; et al, Tetrahedron Letters, 2002, 43(10), 1877-1879

合成路线：1 步

3585-93-1

_88%

反应条件：

1.1 Reagents: Triphenylphosphine , Iodine Solvents: Benzene

参考文献：

Deoxygenation of α-aryl-N-phenylnitrones with diiodotriphenylphosphorane

Furukawa, Isao; et al, Nippon Kagaku Kaishi, 1989, (10), 1748-52

合成路线：1 步

103-33-3

_90%

反应条件：

1.1 Reagents: Cesium hydroxide Catalysts: 1,10-Phenanthroline , Cobalt (reaction product with 1,10-phenanthroline/HMTA/Melamine, carbon-suppor…) Solvents: Toluene ; 24 h, 130 °C

参考文献：

Heterogeneous cobalt-catalyzed degradation of azo compounds using alcohols as the stoichiometric hydrogen source

Panja, Dibyajyoti; et al, Journal of Environmental Chemical Engineering, 2023, 11(2),

合成路线：1 步

103-33-3

_81%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: 2923249-07-2 Solvents: Toluene ; 20 h, 130 °C

参考文献：

Chemodivergent coupling of azoarenes with benzyl alcohols via a borrowing hydrogen strategy using a well-defined nickel catalyst

Bansal, Sadhna; et al, Catalysis Science & Technology, 2023, 13(9), 2705-2713

合成路线：1 步

104-87-0

_90%

反应条件：

1.1 Solvents: Ethanol ; 3 h, reflux

参考文献：

Synthesis of structurally diverse 2-azetidinones via Staudinger reaction on a solid support

Jarrahpour, Aliasghar; et al, Bulletin of the Chemical Society of Japan, 2011, 84(3), 320-327

合成路线：1 步

622-37-7

_90%

反应条件：

1.1 Reagents: Triphenylphosphine Catalysts: Methyltrioxorhenium Solvents: Benzene ; 10 min, rt
1.2 2 h, rt

参考文献：

Organic Reactions Catalyzed by Methylrhenium Trioxide: Reactions of Ethyl Diazoacetate and Organic Azides

Zhu, Zuolin; et al, Journal of the American Chemical Society, 1996, 118(41), 9901-9907

合成路线：1 步

622-37-7

_87%

反应条件：

1.1 Reagents: Triphenylphosphine , Potassium hydroxide Catalysts: (OC-6-12)-Dichloro[4-[[(S)-ethylthio-κS]methyl]acridine-κN](triphenylphosphine)r… Solvents: Toluene ; rt → 135 °C; 18 h, 135 °C

参考文献：

Acceptorless dehydrogenative construction of C=N and C=C bonds through catalytic aza-Wittig and Wittig reactions in the presence of an air-stable ruthenium pincer complex

Biswas, Nandita; et al, Dalton Transactions, 2019, 48(19), 6501-6512

合成路线：1 步

622-37-7

_84%

反应条件：

1.1 Reagents: Potassium tert-butoxide Catalysts: 2633072-21-4 Solvents: Toluene ; 18 h, 130 °C

参考文献：

Redox-Neutral Imination of Alcohol with Azide: A Sustainable Alternative to the Staudinger/Aza-Wittig Reaction

Li, Huaifeng; et al, ACS Catalysis, 2021, 11(7), 4071-4076

合成路线：1 步

959-33-1

64-10-8

_79%

反应条件：

1.1 Catalysts: Potassium hydroxide ; 24 h, 135 °C

参考文献：

Base-catalyzed synthesis of amides and imines via C-C and C=C bond cleavage

Yadav, Dilip Kumar T.; et al, RSC Advances, 2015, 5(16), 12387-12391

合成路线：1 步

103-71-9

_70%

反应条件：

1.1 Catalysts: Titanium tetrabutoxide Solvents: Tetrahydrofuran ; rt; 54 h, rt
1.2 Reagents: Water ; rt; 1 h, rt

参考文献：

Room temperature metathesis of aryl isocyanates and aromatic aldehydes catalyzed by group(IV) metal alkoxides: An experimental and computational study

Kumar, Akshai; et al, Journal of Organometallic Chemistry, 2010, 695(3), 338-345

合成路线：1 步

32979-94-5

_67%

反应条件：

1.1 Reagents: Boron trifluoride etherate , Oxygen Solvents: Acetonitrile-d3

参考文献：

Oxidative carbon-carbon bond cleavage reaction of 1,2-diamines and 1,2-amino alcohols under an oxygen atmosphere

Shimizu, Makoto; et al, Tetrahedron Letters, 2001, 42(50), 8865-8868

合成路线：1 步

100-52-7

反应条件：

1.1 Solvents: Ethanol ; 20 min, 50 °C

参考文献：

(R)-oxynitrilases as biocatalysts for the addition of cyanide to phenylimines

Solis O., Aida; et al, Revista Mexicana de Ciencias Farmaceuticas, 2002, 33(4), 27-31

合成路线：1 步

38968-72-8

反应条件：

1.1 Catalysts: Acetic acid

参考文献：

A simple high yield conversion of imidoyl chlorides to imines and amines

Alper, Howard; et al, Synthesis, 1978, (10), 781-2

合成路线：1 步

45821-44-1