86-26-0 (2-甲氧基联苯,2-Methoxybiphenyl)

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium diacetate , 1,4-Benzenedicarboxaldehyde, polymer with 4,4′,4′′,4′′′-methanetetrayltetrakis[b… Solvents: Methanol , Water ; 20 min, 70 °C

参考文献：

Heterogeneous Catalysis by Covalent Organic Frameworks (COF): Pd(OAc)2@COF-300 in Cross-Coupling Reactions

Goncalves, Raoni S. B.; et al, ChemCatChem, 2016, 8(4), 743-750

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: (SP-4-2)-[1,1′-Bis[bis(1,1-dimethylethyl)phosphino-κP]ferrocene]dichloropalladiu… Solvents: Acetonitrile , Water ; 1 - 2 h, 60 °C

参考文献：

A mild robust generic protocol for the Suzuki reaction using an air stable catalyst

Moseley, Jonathan D.; et al, Tetrahedron, 2012, 68(30), 6010-6017

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium carbonate , Oxygen Catalysts: Palladium (Al(OH)3-supported) Solvents: Dimethylformamide , Water ; 1.5 h, 40 °C

参考文献：

An efficient Pd/Al(OH)3 nanoparticle catalyst for Suzuki coupling reactions of aryl halides

Li, Xing; et al, Synthesis, 2014, 46(12), 1593-1602

合成路线：1 步

153766-81-5

_100%

反应条件：

1.1 Reagents: Diisopropylethylamine Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Isopropanol , Dichloromethane , Water ; 10 min, 100 °C

参考文献：

Microwave-enhanced cross-coupling reactions involving potassium organotrifluoroborates

Kabalka, George W.; et al, Tetrahedron Letters, 2005, 46(37), 6329-6331

合成路线：1 步

153766-81-5

_84%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Palladium diacetate Solvents: Choline chloride ; 5 h, 60 °C

参考文献：

Ligand-Free Bioinspired Suzuki-Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents

Dilauro, Giuseppe ; et al, ChemSusChem, 2018, 11(19), 3495-3501

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Ethanol ; 3.5 h, 80 °C

参考文献：

Palladium Nanoparticle-Embedded Polymer Thin Film "Dip Catalyst" for Suzuki-Miyaura Reaction

Hariprasad, E.; et al, ACS Catalysis, 2012, 2(6), 1179-1186

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: Palladium, bis[μ-[benzenemethanolato(2-)-κC2,κO1:κO1]]bis(triphenylarsine)di- Solvents: Dimethylformamide

参考文献：

Palladacycles as precatalysts in Heck and cross-coupling reactions

Munoz, M. Paz; et al, Advanced Synthesis & Catalysis, 2001, 343(4), 338-342

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Ethanol , Water ; 1 h, 75 °C

参考文献：

Palladium Supported on Silk Fibroin for Suzuki-Miyaura Cross-Coupling Reactions

Rizzo, Giorgio ; et al, European Journal of Organic Chemistry, 2020, 2020(45), 6992-6996

合成路线：1 步

591-50-4

_100%

反应条件：

参考文献：

Heterogeneous Catalysis by Covalent Organic Frameworks (COF): Pd(OAc)2@COF-300 in Cross-Coupling Reactions

Goncalves, Raoni S. B.; et al, ChemCatChem, 2016, 8(4), 743-750

合成路线：1 步

591-50-4

_99%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Hexaiodo[1-[2-[4-(isocyano-κC)-3,5-bis(1-methylethyl)phenyl]ethynyl]-3,5-bis[2-[… Solvents: Methanol ; 8 h, 70 °C

参考文献：

A palladium-carbon-connected organometallic framework and its catalytic application

Dong, Ying; et al, Chemical Communications (Cambridge, 2019, 55(96), 14414-14417

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate , Oxygen Catalysts: 2842071-38-7 Solvents: Ethanol , Water ; 6 h, 80 °C

参考文献：

Palladium complexes of PNNP type diiminodiphosphine ligands for the Suzuki C-C coupling reactions

Tezcan, Burcu; et al, Inorganica Chimica Acta, 2022, 543,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: 2723513-15-1 Solvents: Dimethylformamide , Water ; 20 h, 100 °C

参考文献：

[6,5] CNN Palladium(II) Pincer Complexes Containing N-Substituted Monoanionic and Dianionic Guanidinate Ligands: Syntheses, Structural Aspects, and Their Utility in Suzuki-Miyaura Coupling Reactions

Sinha, Nitish Kumar; et al, Organometallics, 2021, 40(21), 3535-3549

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Ethanol , Water ; 60 min, 50 °C

参考文献：

In situ grown palladium nanoparticles on polyester fabric as easy-separable and recyclable catalyst for Suzuki-Miyaura reaction

Xu, Tiefeng; et al, Catalysis Communications, 2021, 157,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Polyoxyethanyl α-tocopheryl sebacate , stereoisomer of [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2… Solvents: Water ; 6 h, 23 °C

参考文献：

Room-Temperature Suzuki-Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles

Lipshutz, Bruce H.; et al, Organic Letters, 2008, 10(7), 1333-1336

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Bis(benzonitrile)dichloropalladium , 2925303-71-3 Solvents: Toluene ; 12 h, rt
1.2 Reagents: Potassium carbonate Solvents: Toluene , Water ; 2 h, 80 °C

参考文献：

Porous Supramolecular Assemblies for Efficient Suzuki Coupling of Aryl Chlorides

Chen, Fang; et al, Small, 2023, 19(36),

合成路线：1 步

1207429-55-7

_99%

反应条件：

1.1 Catalysts: 2134194-87-7 Solvents: Diethyl ether , tert-Amyl methyl ether ; 30 min, rt; 16 h, 50 °C

参考文献：

Less hindered ligands give improved catalysts for the nickel catalysed Grignard cross-coupling of aromatic ethers

Harkness, Gavin J.; et al, Catalysis Science & Technology, 2018, 8(1), 328-334

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Palladium Solvents: Toluene ; 20 min, 140 °C

参考文献：

Encapsulated palladium catalysts

Pears, David A.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2008, 1, 1-5

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Triphenylphosphine , Palladium, [N,N′-bis[3-(triethoxysilyl)propyl][2,2′-bipyridine]-4,4′-dimethanami… (MCM-41-anchored) Solvents: Tetrahydrofuran ; 24 h, reflux

参考文献：

Anchored palladium bipyridyl complex in nanosized MCM-41: A recyclable and efficient catalyst for the Kumada-Corriu reaction

Tsai, Fu-Yu; et al, Tetrahedron, 2007, 63(20), 4304-4309

合成路线：1 步

_90%

反应条件：

1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium , 3-(1,1-Dimethylethyl)-1-[2-(diphenylphosphino)phenyl]-5-methyl-1H-pyrazole Solvents: Toluene , Tetrahydrofuran ; rt; 10 h, 55 °C
1.2 Reagents: Water ; rt

参考文献：

Pyrazole-tethered phosphine ligands for Pd(0): useful catalysts for Stille, Kumada and Hiyama cross-coupling reactions

Pal, Anwesha; et al, Tetrahedron, 2010, 66(29), 5451-5458

合成路线：1 步

5720-07-0

_99%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: Palladium , 2570110-06-2 Solvents: Methanol , Water ; 10 min, rt
1.2 rt; 10 min, 30 °C; 5 h, 30 °C

参考文献：

Pyridine-based hypercrosslinked polymers as support materials for palladium photocatalysts and their application in Suzuki-Miyaura coupling reactions

Zhang, Yan; et al, New Journal of Chemistry, 2020, 44(35), 15202-15208

合成路线：1 步

5720-07-0

_55%

反应条件：

1.1 Reagents: Lithium hydroxide Catalysts: [N-[(2-Pyridinyl-κN)carbonyl]-L-valinato(2-)-κN,κO]palladium Solvents: Methanol ; 10 h, rt

参考文献：

Trifunctional N,N,O-Terdentate Amido/Pyridyl Carboxylate Ligated Pd(II) Complexes for Heck and Suzuki Reactions

Kantam, M. Lakshmi; et al, Journal of Organic Chemistry, 2009, 74(13), 4882-4885

合成路线：1 步

38111-44-3

_99%

反应条件：

1.1 Catalysts: (SP-4-1)-[1,3-Bis[2,6-bis(1-ethylpropyl)phenyl]-1,3-dihydro-2H-imidazol-2-yliden… Solvents: Tetrahydrofuran ; 2 h, rt

参考文献：

On the remarkably different role of salt in the cross-coupling of arylzincs from that seen with alkylzincs

McCann, Lucas C.; et al, Angewandte Chemie, 2014, 53(17), 4386-4389

合成路线：1 步

38111-44-3

_85%

反应条件：

1.1 Reagents: Lithium chloride Catalysts: Nickel(1+), chloro[N,N′-[6-(dimethylamino)-1,3,5-triazine-2,4-diyl-κN3]bis[P,P-b… Solvents: Tetrahydrofuran ; rt; 6 h, 60 °C

参考文献：

A triazine-based Ni(II) PNP pincer complex as catalyst for Kumada-Corriu and Negishi cross-coupling reactions

Mastalir, Mathias; et al, Monatshefte fuer Chemie, 2017, 148(1), 105-109

合成路线：1 步

38111-44-3

_93%

反应条件：

1.1 Catalysts: [2′,6′-Bis(1-methylethoxy)[1,1′-biphenyl]-2-yl]dicyclohexylphosphine , 2751616-98-3 Solvents: Tetrahydrofuran ; 20 min, rt
1.2 Reagents: N,N,N′,N′-Tetramethylethylenediamine , Tetradecane Solvents: Tetrahydrofuran ; 16 h, rt

参考文献：

Halogen-Bridged Methylnaphthyl Palladium Dimers as Versatile Catalyst Precursors in Coupling Reactions

Sivendran, Nardana ; et al, Angewandte Chemie, 2021, 60(47), 25151-25160

合成路线：1 步

934-56-5

_99%

反应条件：

1.1 Reagents: Tetrabutylammonium acetate Catalysts: Palladium Solvents: Isopropanol , Toluene ; 90 °C

参考文献：

Encapsulated palladium catalysts

Pears, David A.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2008, 1, 1-5

合成路线：1 步

934-56-5

_74%

反应条件：

1.1 Reagents: Tetrabutylammonium acetate Catalysts: Palladium diacetate Solvents: Isopropanol , Toluene

参考文献：

Polyurea-encapsulated palladium(II) acetate: a robust and recyclable catalyst for use in conventional and supercritical media

Ley, Steven V.; et al, Chemical Communications (Cambridge, 2002, (10), 1134-1135

合成路线：1 步

934-56-5

_54%

反应条件：

1.1 Catalysts: (SP-4-1)-[2,6-Bis[(diphenylphosphino-κP)methyl]phenyl-κC](2,2,2-trifluoroacetato… Solvents: Toluene ; 18 h, 160 °C

参考文献：

A catalytic and mechanistic investigation of a PCP pincer palladium complex in the Stille reaction

Olsson, Daniel; et al, Dalton Transactions, 2005, (11), 1924-1929

合成路线：1 步

321-28-8

_98%

反应条件：

1.1 Catalysts: Bis(acetylacetonato)nickel , Tris(2,4-di-tert-butylphenyl) phosphite Solvents: Tetrahydrofuran ; rt → 150 °C; 10 min, 150 °C; 150 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Transition metal catalyzed cross-coupling of aryl Grignard reagents with aryl fluorides via Pd- or Ni-activation of the C-F bond: an efficient synthesis of unsymmetrical biaryls - application of microwave technology in ligand and catalyst screening

Dankwardt, John W., Journal of Organometallic Chemistry, 2005, 690(4), 932-938

合成路线：1 步

321-28-8

_93%

反应条件：

1.1 Catalysts: Bis(acetylacetonato)nickel , 2-(Diphenylphosphino)-α-methylbenzenemethanol Solvents: Diethyl ether ; 9 h, 25 °C; 25 °C → 0 °C
1.2 Reagents: Methanol ; 0 °C

参考文献：

Hydroxyphosphine Ligand for Nickel-Catalyzed Cross-Coupling through Nickel/Magnesium Bimetallic Cooperation

Yoshikai, Naohiko; et al, Journal of the American Chemical Society, 2009, 131(27), 9590-9599

合成路线：1 步

321-28-8

_93%

反应条件：

1.1 Catalysts: Bis(acetylacetonato)nickel , 2-(Diphenylphosphino)-α-methylbenzenemethanol Solvents: Diethyl ether ; 9 h, rt; rt → 0 °C
1.2 Reagents: Methanol ; 0 °C

参考文献：

Nickel-Catalyzed Cross-Coupling Reaction of Aryl Fluorides and Chlorides with Grignard Reagents under Nickel/Magnesium Bimetallic Cooperation

Yoshikai, Naohiko; et al, Journal of the American Chemical Society, 2005, 127(51), 17978-17979

合成路线：1 步

1032197-66-2

591-50-4

_98%

反应条件：

1.1 Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Hexane ; 18 h, reflux
1.2 Reagents: Ammonium chloride Solvents: Hexane , Water

参考文献：

Alkali-metal-mediated manganation(II) of functionalized arenes and applications of ortho-manganated products in Pd-catalyzed cross-coupling reactions with iodobenzene

Blair, Victoria L.; et al, Chemistry - A European Journal, 2008, 14(1), 65-72

合成路线：1 步

1078-58-6

_98%

反应条件：

1.1 Catalysts: (SP-4-1)-[1,3-Bis[2,6-bis(1-ethylpropyl)phenyl]-1,3-dihydro-2H-imidazol-2-yliden… Solvents: Tetrahydrofuran ; 8 h, rt

参考文献：

On the remarkably different role of salt in the cross-coupling of arylzincs from that seen with alkylzincs

McCann, Lucas C.; et al, Angewandte Chemie, 2014, 53(17), 4386-4389

合成路线：1 步

108-90-7

_98%

反应条件：

1.1 Reagents: Potassium fluoride , 18-Crown-6 Catalysts: Palladium diacetate , 1H-Imidazolium, 1,3-bis(7,10-dicyclohexyl-9-phenanthrenyl)-4,5-dihydro-, chlorid… Solvents: Tetrahydrofuran ; 24 h, 50 °C

参考文献：

Palladium catalyzed Suzuki-Miyaura coupling with aryl chlorides using a bulky phenanthryl N-heterocyclic carbene ligand

Song, Chun; et al, Tetrahedron, 2005, 61(31), 7438-7446

合成路线：1 步

108-90-7

_87%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: Palladium diacetate , 1-(Dicyclohexylphosphino)-2-(2-methylphenyl)ferrocene Solvents: 1,4-Dioxane ; 24 h, 95 °C

参考文献：

Ferrocenyl monophosphine ligands: Synthesis and applications in the Suzuki-Miyaura coupling of aryl chlorides

Baillie, Colin; et al, Journal of Organic Chemistry, 2004, 69(22), 7779-7782

合成路线：1 步

18114-68-6

_98%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Triphenylphosphine , Palladium diacetate Solvents: 2-Methoxyethanol , Water ; 6 h, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Palladium-catalyzed cross-coupling reaction of potassium diaryldifluoroborates with aryl halides

Ito, Takatoshi; et al, Synlett, 2003, (10), 1435-1438

合成路线：1 步

2596314-29-1

_98%

反应条件：

1.1 Reagents: Formic acid , Triethylamine Catalysts: Palladium diacetate , 1,1-Bis(diphenylphosphino)ferrocene Solvents: Dimethylformamide ; 15 h, 80 °C

参考文献：

Homogeneous Palladium-Catalyzed Selective Reduction of 2,2'-Biphenols Using HCO2H as Hydrogen Source

Li, Ruoling; et al, Synthesis, 2021, 53(9), 1605-1618

合成路线：1 步

99-91-2

_98%

反应条件：

1.1 Catalysts: Triphenylphosphine , Palladium diacetate Solvents: 2-Methoxyethanol , Water ; 6 h, reflux

参考文献：

Palladium-catalyzed cross-coupling reaction of diarylboron compounds with aryl halides

Ito, Takatoshi; et al, Kagaku to Kogyo (Osaka, 2006, 80(9), 430-436

合成路线：1 步

591-51-5

_98%

反应条件：

1.1 Reagents: 1,3-Dihydro-1,1-bis(1-methylethyl)-3,3-bis(trifluoromethyl)-2,1-benzoxasilole Solvents: Tetrahydrofuran , Butyl ether ; -78 °C; -78 °C → rt; 1.5 h, rt
1.2 Catalysts: X-Phos , (SP-4-3)-[Dicyclohexyl[2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphin… Solvents: Tetrahydrofuran ; 24 h, 70 °C
1.3 Reagents: Water

参考文献：

Design, Synthesis, and Validation of an Effective, Reusable Silicon-Based Transfer Agent for Room-Temperature Pd-Catalyzed Cross-Coupling Reactions of Aryl and Heteroaryl Chlorides with Readily Available Aryl Lithium Reagents

Martinez-Solorio, Dionicio; et al, Journal of the American Chemical Society, 2016, 138(6), 1836-1839

合成路线：1 步

591-51-5

_86%