882-06-4 (反-4-硝基肉桂酸,4-Nitrocinnamic acid)

_100%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Diethylenetriamine , Tetrabutylammonium chloride , Palladium Solvents: Dimethylformamide ; 12 h, 120 °C
1.2 Reagents: Sodium carbonate Solvents: Water ; 10 min, cooled

参考文献：

Synthesis of lignin-amine supported palladium catalysts for Heck reaction

Wu, Yufeng; et al, Shiyou Huagong, 2009, 38(7), 733-738

合成路线：1 步

100-00-5

_93%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Iron oxide (Fe3O4) (palladium dichloride complex with polymer support from undecylenic aci…) , Palladium chloride (polymer support from triiron tetroxide, undecylenic acid, 4-vinylpyrid…) Solvents: Water ; 24 h, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2, rt

参考文献：

Magnetic polymer nanocomposite-supported Pd: an efficient and reusable catalyst for the Heck and Suzuki reactions in water

Wang, Dongfang; et al, New Journal of Chemistry, 2015, 39(3), 2052-2059

合成路线：1 步

100-00-5

_92%

反应条件：

1.1 Reagents: Triethylamine Catalysts: 1621954-77-5 Solvents: Dimethylformamide ; 2.5 h, 120 °C

参考文献：

Highly active recyclable SBA-15-EDTA-Pd catalyst for Mizoroki-Heck, Stille and Kumada C-C coupling reactions

Rathod, Jayant; et al, Journal of Porous Materials, 2017, 24(4), 837-846

合成路线：1 步

141-82-2

_100%

反应条件：

1.1 Reagents: Pyridine Solvents: Dimethylformamide ; 3 - 5 h, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ

Li, Xin; et al, European Journal of Medicinal Chemistry, 2015, 97, 32-41

合成路线：1 步

141-82-2

_100%

反应条件：

1.1 Reagents: Pyridine Solvents: Dimethylformamide ; 3 - 5 h, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Phenylacrylamides as novel FtsZ-targeted potential antimicrobials

Li, Xin; et al, Letters in Drug Design & Discovery, 2015, 12(3), 234-240

合成路线：1 步

636-98-6

_100%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Palladium, [4,4′-bis[[(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heneicosaf… Solvents: Dimethylformamide ; 3 h, 120 °C

参考文献：

High fluorine content bis(fluoro-ponytailed) bipyridine palladium complexes as catalyst for Mizoroki-Heck reactions under fluorous biphasic catalysis conditions

Lu, Norman; et al, Journal of the Chinese Chemical Society (Taipei, 2008, 55(1), 89-96

合成路线：1 步

636-98-6

_99%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Toluene , Palladium diacetate , Poly(oxy-1,2-ethanediyl), α-[2-(1-methyl-1H-imidazolium-3-yl)ethyl]-ω-[2-(1-meth… ; 2.5 h, 110 °C

参考文献：

An efficient and recyclable ligand-free PEG1000-DIL/toluene temperature-dependent biphasic system for palladium catalysed Heck reactions

Liu, Xiang; et al, Journal of Chemical Research, 2011, 35(12), 731-733

合成路线：1 步

2033-24-1

_99%

反应条件：

1.1 Solvents: Water ; 5 min

参考文献：

A green chemical synthesis of coumarin-3-carboxylic and cinnamic acids using crop-derived products and waste waters as solvents

Fiorito, Serena; et al, Tetrahedron Letters, 2016, 57(43), 4795-4798

合成路线：1 步

3095-95-2

_99%

反应条件：

1.1 Reagents: N,N,N′,N′-Tetramethylethylenediamine , 1,8-Diazabicyclo[5.4.0]undec-7-ene , Zinc triflate Solvents: Tetrahydrofuran ; 12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Mild zinc-promoted Horner-Wadsworth-Emmons reactions of diprotic phosphonate reagents

Schauer, Douglas J.; et al, Synthesis, 2006, (21), 3654-3660

合成路线：1 步

24393-61-1

_98%

反应条件：

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water ; 24 h, 25 °C

参考文献：

Larvicidal activity and in silico studies of cinnamic acid derivatives against Aedes aegypti (Diptera: Culicidae)

Bezerra Franca, Saraliny; et al, Bioorganic & Medicinal Chemistry, 2021, 44,

合成路线：1 步

24393-61-1

_95%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 12 h, 65 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Facile, direct reaction of benzaldehydes to 3-arylprop-2-enoic acids and 3-arylprop-2-ynoic acids in aqueous medium

Thiemann, Thies; et al, International Journal of Organic Chemistry, 2016, 6(2), 126-141

合成路线：1 步

24393-61-1

_92%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol , Water ; 6 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified, cooled

参考文献：

Synthesis and biological evaluation of N-(substituted cinnamoyl)-N'-(pyridin-2-yl)piperazine as antioxidants

Desale, Kamlesh R.; et al, International Journal of Pharma and Bio Sciences, 2013, 4(3), 97-103

合成路线：1 步

25322-68-3

_98%

反应条件：

1.1 Reagents: Diisopropylcarbodiimide , 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ; heated; 20 h, 50 °C

参考文献：

Design of a Membrane Fluorescent Sensor Based on Photo-Cross-Linked PEG Hydrogel

Zheng, Yujun; et al, Journal of Physical Chemistry B, 2003, 107(2), 483-488

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Tetrabutylammonium bromide , Palladium Solvents: Dimethylformamide ; 7 h, 120 °C; 120 °C → rt
1.2 Reagents: Sodium carbonate Solvents: Water ; 20 min, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2, rt

参考文献：

Preparation of Pd nanoparticles deposited on a polyaniline/multiwall carbon nanotubes nanocomposite and their application in the Heck reaction

Nie, Guangrui; et al, Reaction Kinetics, 2013, 108(1), 193-204

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Divinylbenzene-styrene copolymer (chloromethylated, guanidinylation reaction products with guanidinium c…) Solvents: N-Methyl-2-pyrrolidone ; 30 min, 140 °C

参考文献：

Guanidine-functionalized resin-supported Pd(0) catalyst: activity, reusability, and redeposition of active Pd species in Heck vinylation

Yang, Yuan-Fa; et al, Chinese Journal of Chemistry, 2008, 26(1), 30-34

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Ethylenediamine , Palladium , Polyacrylonitrile ; 20 min, 120 °C

参考文献：

Functional fiber with bis (N-heterocyclic carbene) structure prevents Pd(0) nanoparticle agglomeration for an efficient and recyclable Heck reaction

Zhang, Haonan; et al, Chemical Engineering Journal (Amsterdam, 2023, 455,

合成路线：1 步

637-57-0

_92%

反应条件：

1.1 Reagents: Lithium hydroxide Solvents: Methanol , Tetrahydrofuran , Water ; rt; 2.5 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Examination of Phosphoryl-Mimicking Functionalities within a Macrocyclic Grb2 SH2 Domain-Binding Platform

Kang, Sang-Uk; et al, Journal of Medicinal Chemistry, 2005, 48(12), 3945-3948

合成路线：1 步

5576-98-7

558-13-4

_96%

反应条件：

1.1 Reagents: Diisopropylamine Catalysts: Tris(2,2′-bipyridyl)ruthenium(II) chloride Solvents: Acetonitrile , Water ; 10 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Visible-light-enabled denitrative carboxylation of β-nitrostyrenes: a direct photocatalytic approach to cinnamic acids

Tripathi, Shubhangi; et al, New Journal of Chemistry, 2018, 42(5), 3765-3769

合成路线：1 步

113-24-6

_93%

反应条件：

1.1 Solvents: Dimethyl sulfoxide , Water ; 16 h, pH 6.5, rt
1.2 Reagents: Hydrogen peroxide Solvents: Water ; 30 min, rt
1.3 Reagents: Sodium pyrosulfite ; 5 min, rt
1.4 pH 4

参考文献：

Biocatalytic Synthesis of α,β-Unsaturated 2-Keto Acids and Derivatives Using the Promiscuous Aldolase, NahE

Fansher, Douglas J.; et al, Synthesis, 2023, 55(1), 75-89

合成路线：1 步

591-50-4

_91%

反应条件：

1.1 Reagents: Sodium dodecyl sulfate , Sodium carbonate Catalysts: 2035931-31-6 (MNP-supported) Solvents: Water ; 6 h, reflux

参考文献：

Suzuki and Heck cross-coupling reactions using ferromagnetic nanoparticle-supported palladium complex as an efficient and recyclable heterogeneous nanocatalyst in sodium dodecylsulfate micelles

Bahrami, Kiumars; et al, Applied Organometallic Chemistry, 2017, 31(6),

合成路线：1 步

41468-11-5

141-82-2

_89%

反应条件：

1.1 Reagents: Piperazine Solvents: Ethylene glycol ; 8 min

参考文献：

Synthesis of trans-cinnamic acids from aryl aldehydes and aryl aldehyde bisulfite adducts with malonic acid using piperazine

Khosropour, Ahmad Reza; et al, Journal of Chemical Research, 2005, (6), 364-365

合成路线：1 步

1663-39-4

_88%

反应条件：

1.1 Reagents: Diisopropylethylamine Catalysts: (SP-4-4)-Chloro[1,3-dihydro-1,3-bis(2,4,6-trimethylphenyl)-2H-imidazol-2-ylidene… ; 18 h, 120 °C; cooled

参考文献：

N-Heterocycle carbene (NHC)-ligated cyclopalladated N,N-dimethylbenzylamine: A highly active, practical and versatile catalyst for the Heck-Mizoroki reaction

Peh, Guang-Rong; et al, Organic & Biomolecular Chemistry, 2009, 7(10), 2110-2119

合成路线：1 步

_88%

反应条件：

1.1 Catalysts: Palladium , Cellulose, carboxymethyl ether Solvents: Water ; 6 h, rt

参考文献：

Carboxymethylcellulose-supported palladium nanoparticles generated in situ from palladium(II) carboxymethylcellulose as an efficient and reusable catalyst for ligand- and base-free Heck-Matsuda and Suzuki-Miyaura couplings

Xiao, Jinlong; et al, Applied Organometallic Chemistry, 2015, 29(9), 646-652

合成路线：1 步

64-19-7

_85%

反应条件：

1.1 Reagents: Pyridine , 4-(Dimethylamino)pyridine , Sodium tetraborate , Lithium chloride Solvents: N-Methyl-2-pyrrolidone ; 2 - 2.5 h, reflux
1.2 reflux
1.3 70 - 90 °C; 10 h, 185 - 190 °C
1.4 Reagents: Sodium hydroxide Solvents: Water ; pH 9 - 10, rt
1.5 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2, rt

参考文献：

A novel direct boron-mediated synthesis of cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids

Chiriac, Constantin I.; et al, Revue Roumaine de Chimie, 2009, 54(11-12), 987-991

合成路线：1 步

64-19-7

_84%