886-60-2 (1-苯基-3-(2-吡啶基)-2-硫脲,1-Phenyl-3-(2-pyridyl)-2-thiourea)

103-71-9

_97%

反应条件：

1.1 Solvents: Toluene ; rt → reflux; 5 h, reflux

参考文献：

Fused polycyclic nitrogen-containing heterocycles

Mamedov, V. A.; Zhukova, N. A.; Beschastnova, T. N.; Levin, Ya. A.; Gubaidullin, A. T.; et al, Russian Chemical Bulletin, 2007, 56(11), 2308-2314

合成路线：1 步

_96%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 15 min, 20 - 25 °C; 2 h, 20 - 25 °C

参考文献：

A novel thiourea derivative for preconcentration of copper(II), nickel(II), cadmium(II), lead(II) and iron(II) from seawater samples for Flame Atomic Absorption Spectrophotometry

Sanlier Ucak, Sengul; Aydin, Adnan, Marine Pollution Bulletin, 2022, 180,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Sodium hydride Solvents: 1,4-Dioxane ; 0 °C → rt

参考文献：

A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779

Dugan, Benjamin J.; Gingrich, Diane E.; Mesaros, Eugen F.; Milkiewicz, Karen L.; Curry, Matthew A.; et al, Journal of Medicinal Chemistry, 2012, 55(11), 5243-5254

合成路线：1 步

_96%

反应条件：

1.1 Solvents: Ethanol

参考文献：

Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones

Kumar, K. S.; Singh, S. K.; Pandeya, S. N., Bollettino Chimico Farmaceutico, 2001, 140(4), 238-242

合成路线：1 步

_95%

反应条件：

1.1 Solvents: 1,4-Dioxane

参考文献：

High-Pressure Organic Chemistry. Part 25. High-pressure-promoted addition of isothiocyanates to aminopyridines: efficient synthesis of pyridine-thiourea conjugates as building blocks for hydrogen-bonding receptors

Kumamoto, Koji; Misawa, Yoshihiro; Tokita, Sumio; Kubo, Yuji; Kotsuki, Hiyoshizo, Tetrahedron Letters, 2002, 43(6), 1035-1038

合成路线：1 步

15009-91-3

_94%

反应条件：

1.1 Reagents: Sodium borohydride Catalysts: Tris[μ-[2-amino-1,4-benzenedicarboxylato(2-)-κO1:κO′1]]diaquafluoro-μ3-oxotrichr… (post-treated with cyanuric chloride; aminopyridine; NiCl2) Solvents: Water ; 20 min, rt

参考文献：

Green synthesis of thiourea derivatives from nitrobenzenes using Ni nanoparticles immobilized on triazine-aminopyridine-modified MIL-101(Cr) MOF

Heidari, Sara; Alavinia, Sedigheh; Ghorbani-Vaghei, Ramin, Scientific Reports, 2023, 13(1),

合成路线：1 步

_94%

反应条件：

1.1 Solvents: Dichloromethane ; rt; 4 h, reflux

参考文献：

Synthesis and biological evaluation of novel 2-imino-4-thiazolidinones as potential antitumor agents for glioblastoma

Campos, Jose Coan; Campos, Patrick Teixeira; Pedra, Nathalia Stark; Bona, Natalia Pontes ; Soares, Mayara Sandrielly ; et al, Medicinal Chemistry (Sharjah, 2022, 18(4), 452-462

合成路线：1 步

_92%

反应条件：

1.1 Solvents: tert-Butanol ; 20 h, reflux

参考文献：

Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis

Calixto, Sanderson Dias; Simao, Thatiana Lopes Bia Ventura; Palmeira-Mello, Marcos Vinicius; Viana, Gil Mendes; Assumpcao, Paloma Wetler Meireles Carreiros; et al, Bioorganic & Medicinal Chemistry, 2022, 53,

合成路线：1 步

_92%

反应条件：

1.1 Solvents: Dimethyl sulfoxide ; 4 min, 120 °C

参考文献：

Diversity-Oriented Synthesis of Thiazolidine-2-imines via Microwave-Assisted One-Pot, Telescopic Approach and Its Interaction with Biomacromolecules

Saikia, Ananya Anubhav; Rao, Ramdas Nishanth; Maiti, Barnali ; Balamurali, Musuvathi Motilal ; Chanda, Kaushik, ACS Combinatorial Science, 2020, 22(11), 630-640

合成路线：1 步

_91%

反应条件：

1.1 Solvents: Ethanol

参考文献：

1-(Methyldithiocarbonyl)imidazole: a useful thiocarbonyl transfer reagent for synthesis of substituted thioureas

Mohanta, Pramod K.; Dhar, Sanchita; Samal, S. K.; Ila, H.; Junjappa, H., Tetrahedron, 2000, 56(4), 629-637

合成路线：1 步

_90%

反应条件：

1.1 Catalysts: 1-Butyl-3-methylimidazolium tetrafluoroborate Solvents: 1-Butyl-3-methylimidazolium tetrafluoroborate ; 25 min, rt

参考文献：

Organic reactions in ionic liquids: ionic liquid-promoted efficient synthesis of disubstituted and trisubstituted thiourea derivatives

Le, Zhang Gao; Chen, Zhen Chu; Hu, Yi; Zheng, Qin Guo, Chinese Chemical Letters, 2005, 16(2), 201-204

合成路线：1 步

_76%

反应条件：

1.1 10 - 15 min, 100 °C

参考文献：

Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butyrylcholinesterase activities of N,N'-diaryl unsymmetrically substituted thioureas

Begum, Saeedan; Choudhary, M. Iqbal; Khan, Khalid M., Natural Product Research, 2009, 23(18), 1719-1730

合成路线：1 步

_75%

反应条件：

1.1 Solvents: Ethanol ; 8 h, 78 °C

参考文献：

Synthesis, crystal structure, characterization and studies on DNA binding of a novel copper(II) complex [Cu(PyPt)(NO3)2]

Liu, Dan; Zhou, Yin-Zhuang, Wuji Huaxue Xuebao, 2009, 25(10), 1797-1804

合成路线：1 步

_75%

反应条件：

1.1 Solvents: Ethanol ; 2 h, reflux

参考文献：

Synthesis, characterization, crystal structure and luminescence properties of phosphinic silver(I) complexes with thiourea derivatives

Belicchi Ferrari, Marisa; Bisceglie, Franco; Cavalli, Enrico; Pelosi, Giorgio; Tarasconi, Pieralberto; et al, Inorganica Chimica Acta, 2007, 360(10), 3233-3240

合成路线：1 步

_75%

反应条件：

1.1 Solvents: Benzene

参考文献：

Spectroscopic (C-13 NMR, IR and UV-Vis.) and structural characterization and biological activity study of some new Mg(II), Mn(II), Fe(II), Cu(II), Zn(II), Cd(II), and La(III) complexes of 1-phenyl-3-(pyridin-2-yl)-2-thiourea

Sarkis, George Y.; Sarkis, Rony G., Dirasat: Pure Sciences, 2006, 33(1), 21-27

合成路线：1 步

_75%

参考文献：

Synthesis and spectral and biological activity of new complexes in N-phenyl-N'-(2-pyridyl)thiourea with manganese(II), iron(II), cobalt(II) and copper(II)

Sarkis, George Y.; Farah, Robin G., Abhath Al-Yarmouk, 2004, 13(1),

合成路线：1 步

_71%

反应条件：

1.1 Solvents: Benzene ; 1.5 h, reflux; cooled

参考文献：

Palladium(II) and platinum(II) complexes containing the mixed ligands N-phenyl-N'-(2-pyridinyl or 2-pyridinylmethyl)thiourea and diphosphines Ph2P(CH2)nPPh2 (n = 1-4)

Al-Hayaly, Lamaan J.; Abdullah, Bayazeed H.; Al-Dulaimi, Adnan A. N.; Al-Jibori, Subhi A., Oriental Journal of Chemistry, 2008, 24(2), 381-388

合成路线：1 步

_70%

反应条件：

1.1 Reagents: 2,4-Dimethylpyridine , Oxygen Solvents: 1,2-Dichloroethane ; 50 °C

参考文献：

Copper-Catalyzed Aerobic Oxidative [3+2] Annulation for the Synthesis of 5-Amino/Imino-Substituted 1,2,4-Thiadiazoles through C-N/N-S Bond Formation

Yu, Wentao; Huang, Yubing; Li, Jianxiao; Tang, Xiaodong; Wu, Wanqing ; et al, Journal of Organic Chemistry, 2018, 83(16), 9334-9343

合成路线：1 步

_70%

反应条件：

1.1 Solvents: Dichloromethane ; 0 °C; 45 min, 0 °C

参考文献：

Synthesis and in vitro urease inhibitory activity of N,N'-disubstituted thioureas

Khan, Khalid Mohammed; Naz, Farzana; Taha, Muhammad; Khan, Ajmal; Perveen, Shahnaz; et al, European Journal of Medicinal Chemistry, 2014, 74, 314-323

合成路线：1 步

103-85-5

_69%