935-04-6 (乙烯氧基甲基-苯,vinyloxymethylbenzene)

_99%

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Tetrahydrofuran ; 8 h, 60 °C
1.2 Solvents: Pentane ; overnight, 0 °C

参考文献：

Electron-transfer reduction of selected alcohols with alkalide K-, K+(15-crown-5)2 via organometallic intermediates

Grobelny, Zbigniew; Stolarzewicz, Andrzej; Maercker, Adalbert; Krompiec, Stanislaw; Kasperczyk, Janusz; et al, Journal of Organometallic Chemistry, 2004, 689(14), 2361-2367

合成路线：1 步

_99%

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Tetrahydrofuran ; 8 h, 60 °C

参考文献：

Decomposition of vinyl ethers by alkalide K-, K+(15-crown-5)2 via organopotassium intermediates

Grobelny, Zbigniew; Stolarzewicz, Andrzej; Maercker, Adalbert; Krompiec, Stanislaw; Kasperczyk, Janusz; et al, Journal of Organometallic Chemistry, 2004, 689(9), 1580-1585

合成路线：1 步

926-02-3

_98%

反应条件：

1.1 Catalysts: Triethylamine , 4,7-Diphenyl-1,10-phenanthroline , Palladium trifluoroacetate ; 13 h, 75 °C

参考文献：

Synthesis of Allyl and Alkyl Vinyl Ethers Using an in Situ Prepared Air-Stable Palladium Catalyst. Efficient Transfer Vinylation of Primary, Secondary, and Tertiary Alcohols

Bosch, Martin; Schlaf, Marcel, Journal of Organic Chemistry, 2003, 68(13), 5225-5227

合成路线：1 步

_97%

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Tetrahydrofuran ; 12 h, 68 °C

参考文献：

Method for preparing bilastine intermediate

, China, , ,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium Solvents: Toluene ; 2 h, 100 °C

参考文献：

Preparation of vinyl ether compounds using transition metal compound catalysts

, European Patent Organization, , ,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium Solvents: Toluene
1.2 Reagents: Diethyl ether Solvents: Diethyl ether

参考文献：

Development of a Highly Efficient Catalytic Method for Synthesis of Vinyl Ethers

Okimoto, Yoshio; Sakaguchi, Satoshi; Ishii, Yasutaka, Journal of the American Chemical Society, 2002, 124(8), 1590-1591

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Potassium hydroxide , Potassium fluoride Solvents: Dimethyl sulfoxide , Water ; 3 h, 130 °C

参考文献：

Examining the vinyl moiety as a protecting group for hydroxyl (-OH) functionality under basic conditions

Voronin, Vladimir V.; Ledovskaya, Maria S.; Rodygin, Konstantin S.; Ananikov, Valentine P., Organic Chemistry Frontiers, 2020, 7(11), 1334-1342

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Potassium hydroxide , Potassium fluoride Solvents: Dimethyl sulfoxide ; 5 min, rt
1.2 Solvents: Water ; 3 h, 130 °C

参考文献：

A solid acetylene reagent with enhanced reactivity: fluoride-mediated functionalization of alcohols and phenols

Werner, Georg; Rodygin, Konstantin S.; Kostin, Anton A.; Gordeev, Evgeniy G.; Kashin, Alexey S.; et al, Green Chemistry, 2017, 19(13), 3032-3041

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Dimethyl sulfoxide , Water ; 30 min, rt
1.2 rt → 120 °C; 15 h, 120 °C

参考文献：

Synthesis of vinyl ethers of alcohols using calcium carbide under superbasic catalytic conditions (KOH/DMSO)

Matake, Ryosuke; Adachi, Yusuke; Matsubara, Hiroshi, Green Chemistry, 2016, 18(9), 2614-2618

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Potassium tert-butoxide , Water Catalysts: Potassium fluoride Solvents: DMSO-d6 ; 3 h, 130 °C

参考文献：

Direct Synthesis of Deuterium-Labeled O -, S -, N -Vinyl Derivatives from Calcium Carbide

Ledovskaya, Maria S.; Voronin, Vladimir V.; Rodygin, Konstantin S.; Posvyatenko, Alexandra V.; Egorova, Ksenia S.; et al, Synthesis, 2019, 51(15), 3001-3013

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: tert-Butanol ; 2 h, 60 °C
1.2 Reagents: Water

参考文献：

Process for preparation of 3-(benzyloxy)-1-cyclobutanone

, China, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium Solvents: Toluene ; 20 min, 80 °C; 18 h, 80 °C

参考文献：

Process for preparation of vinyl ether compounds

, China, , ,

合成路线：1 步

109-92-2

_90%

反应条件：

1.1 Catalysts: Silver acetate , Chloro(triphenylphosphine)gold ; 10 - 48 h, 50 °C

参考文献：

Au(I) complexes-catalyzed transfer vinylation of alcohols and carboxylic acids

Nakamura, Aki; Tokunaga, Makoto, Tetrahedron Letters, 2008, 49(23), 3729-3732

合成路线：1 步

60633-79-6

_89%

反应条件：

1.1 Reagents: Tributylstannane Catalysts: Azobisisobutyronitrile Solvents: Benzene ; 5 h, reflux; 2 h, reflux

参考文献：

Trimethyl Phosphite as a Trap for Alkoxy Radicals Formed from the Ring Opening of Oxiranylcarbinyl Radicals. Conversion to Alkenes. Mechanistic Applications to the Study of C-C versus C-O Ring Cleavage

Ding, Bangwei; Bentrude, Wesley G., Journal of the American Chemical Society, 2003, 125(11), 3248-3259

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ; 25 min, 0 °C; 3 h, rt
1.2 Reagents: Water ; rt

参考文献：

Chemoselective Formal [4+2] Cycloaddition of 3-Hydroxycyclobutanones with Enones

Harada, Kosuke; Nowaki, Aya; Matsuo, Jun-ichi, Asian Journal of Organic Chemistry, 2013, 2(11), 923-926

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ; 0 °C → rt; 3 h, rt

参考文献：

Preparation of bifunctional compounds for the targeted degradation of androgen receptors

, World Intellectual Property Organization, , ,

合成路线：1 步

74-85-1

_80%

反应条件：

1.1 Reagents: Selenohypobromous acid (polymer-supported) ; 5 min, rt
1.2 Reagents: Sodium hydride Catalysts: Tetrabutylammonium iodide , Potassium iodide Solvents: Dimethylformamide ; 10 h, rt
1.3 Reagents: Hydrogen peroxide Solvents: Tetrahydrofuran , Water ; 30 min, rt

参考文献：

Polymer-supported β-bromoethyl selenide: An efficient reagent for the synthesis of aryl vinyl ethers

Sheng, Shou-Ri; Liu, Xiao-Ling; Wang, Xiang-Cong; Xin, Qin; Song, Cai-Sheng, Synthesis, 2004, (17), 2833-2836

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Dimethyl sulfoxide

参考文献：

Selective Approaches to α- and β-Arylated Vinyl Ethers

Domzalska-Pieczykolan, Anna; Funes-Ardoiz, Ignacio; Furman, Bartlomiej ; Bolm, Carsten, Angewandte Chemie, 2022, 61(1),

合成路线：1 步

_77%