96-45-7 (亚乙基硫脲,2-Imidazolidinethione)

_100%

反应条件：

1.1 Catalysts: Zinc oxide (ZnO) , Alumina

参考文献：

Synthesis of symmetrical N,N'-disubstituted thioureas and heterocyclic thiones from amines and CS2 over a ZnO/Al2O3 composite as heterogeneous and reusable catalyst

Ballabeni, Marco; Ballini, Roberto; Bigi, Franca; Maggi, Raimondo; Parrini, Mauro; et al, Journal of Organic Chemistry, 1999, 64(3), 1029-1032

合成路线：1 步

_99%

反应条件：

1.1 Solvents: Water ; 45 °C; 1 h, 45 °C; 46 °C → 70 °C; 3 h, 70 °C; 70 °C → 80 °C; 80 °C → 90 °C; 90 °C → 100 °C; 100 °C → 102 °C; 2 h, 100 - 102 °C

参考文献：

Preparation of 1,3-disubstituted symmetrical thioureas from primary amines and carbon disulfide

, China, , ,

合成路线：1 步

24521-43-5

_99%

反应条件：

1.1 Catalysts: Dichloro[(1,2,3,6,7,10,11,12-η)-2,6,10-dodecatriene-1,12-diyl]ruthenium Solvents: Water ; 6 h, 90 °C

参考文献：

Ru(IV)-catalyzed isomerization of allylamines in water: A highly efficient procedure for the deprotection of N-allylic amines

Cadierno, Victorio; Garcia-Garrido, Sergio E.; Gimeno, Jose; Nebra, Noel, Chemical Communications (Cambridge, 2005, (32), 4086-4088

合成路线：1 步

_98%

反应条件：

1.1 Solvents: Dimethylformamide ; 5 min, 0 °C
1.2 Reagents: Carbon tetrabromide ; 0.3 h, rt
1.3 Solvents: Water ; 0 °C

参考文献：

Carbon tetrabromide promoted reaction of amines with carbon disulfide: facile and efficient synthesis of thioureas and thiuram disulfides

Liang, Fushun; Tan, Jing; Piao, Chengri; Liu, Qun, Synthesis, 2008, (22), 3579-3584

合成路线：1 步

20950-84-9

_95%

反应条件：

1.1 heated

参考文献：

Carbon disulfide

Schmitt, Christine; Murai, Toshiaki, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2008, 1, 1-4

合成路线：1 步

_94%

反应条件：

1.1 Catalysts: Magnesium oxide Solvents: Ethanol ; 2.5 h, rt

参考文献：

MgO Nanoparticle-Catalyzed Synthesis and Broad-Spectrum Antibacterial Activity of Imidazolidine- and Tetrahydropyrimidine-2-Thione Derivatives

Beyzaei, Hamid ; Kooshki, Somaye; Aryan, Reza; Zahedi, Mohammad Mehdi; Samzadeh-Kermani, Alireza; et al, Applied Biochemistry and Biotechnology, 2018, 184(1), 291-302

合成路线：1 步

_93%

反应条件：

1.1 Catalysts: Hydrochloric acid Solvents: Ethanol , Water ; 1 h, 20 °C

参考文献：

Sono-synthesis of imidazolidine-2-thione as a base compound of some pharmaceutical products

Entezari, M. H.; Asghari, A.; Hadizadeh, F., Ultrasonics Sonochemistry, 2007, 15(2), 119-123

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol ; 3 - 4 h, reflux
1.2 Reagents: Acetic acid ; reflux
1.3 Reagents: Sodium hydroxide , Sodium bisulfite Solvents: Water ; reflux; cooled

参考文献：

Synthesis and structure of some imidazolidine-2-thiones

Zhivotova, T. S.; Gazaliev, A. M.; Fazylov, S. D.; Aitpaeva, Z. K.; Turdybekov, D. M., Russian Journal of Organic Chemistry, 2006, 42(3), 448-450

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol ; 3 - 4 h, heated
1.2 Reagents: Acetic acid Solvents: Acetic acid
1.3 Reagents: Sodium hydroxide , Sodium bisulfite Solvents: Water ; reflux
1.4 Reagents: Hydrochloric acid Solvents: Water ; acidified, cooled

参考文献：

Synthesis and structure of cyclic thioureas from some diamines

Zhivotova, T. S.; Gazaliev, A. M.; Aitpaeva, Z. K., Izvestiya Natsional'noi Akademii Nauk Respubliki Kazakhstan, 2004, (4), 31-33

合成路线：1 步

128-04-1

_92%

反应条件：

1.1 Catalysts: Aluminum chloride Solvents: Dimethylformamide ; 10 - 30 min, 120 °C; 120 °C → rt
1.2 Reagents: Water ; rt

参考文献：

AlCl3-Promoted Synthesis of 2-Mercapto Benzoheterocycles by Using Sodium Dimethyldithiocarbamate as Thiocarbonyl Surrogate

Liu, Xing; Zhang, Shi-Bo; Dong, Zhi-Bing, European Journal of Organic Chemistry, 2018, 2018(39), 5406-5411

合成路线：1 步

57-06-7

_91%

反应条件：

1.1 Solvents: Bromobenzene ; 40 min, heated; rt; rt → -5 °C

参考文献：

Process for the preparation of 1,3-dihydroimidazole-2-thiones

, United States, , ,

合成路线：1 步

262350-35-6

_90%

反应条件：

1.1 Solvents: Ethanol ; 0.5 - 6 h, reflux

参考文献：

1H-imidazole-1-carbodithioic acid, methyl ester

Brown, M. Kevin, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2010, 1, 1-2

合成路线：1 步

262350-35-6

_90%

反应条件：

1.1 Solvents: Ethanol

参考文献：

1-(Methyldithiocarbonyl)imidazole: a useful thiocarbonyl transfer reagent for synthesis of substituted thioureas

Mohanta, Pramod K.; Dhar, Sanchita; Samal, S. K.; Ila, H.; Junjappa, H., Tetrahedron, 2000, 56(4), 629-637

合成路线：1 步

137-26-8

_90%

反应条件：

1.1 Solvents: Acetonitrile

参考文献：

A convenient route to substituted thiocarbamides

Ramadas, Krishnamurthy; Srinivasan, Natarajan, Synthetic Communications, 1995, 25(21), 3381-7

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Mordenite (Al2CaH12(SiO3)10.H2O) Solvents: Ethanol , Water ; 50 °C; 50 °C → 115 °C; 1.5 h, 115 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 10 h, 115 °C

参考文献：

Method for synthesizing bis(trimethylsilyl)-containing heterocyclic compound

, China, , ,

合成路线：1 步

_89%

反应条件：

1.1 Solvents: Water ; 2 h, 60 °C; 60 °C → 100 °C; 1 h, 100 °C

参考文献：

Organic synthesis unit process-thiochemicals and heterocyclic compounds-heterocyclic compounds (2)

Watanabe, Takashi, Fain Kemikaru, 2013, 42(10), 51-61

合成路线：1 步

534-18-9

_88%

反应条件：

1.1 Reagents: 2-Chloro-1-methylpyridinium iodide

参考文献：

A convenient method for the preparation of N,N'-disubstituted thioureas using 2-chloropyridinium salt, sodium trithiocarbonate and amines

Takikawa, Yuji; Inoue, Noriyuki; Sato, Ryu; Takizawa, Saburo, Chemistry Letters, 1982, (5), 641-2

合成路线：1 步

_87%

反应条件：

1.1 Solvents: Ethanol , Water ; 0 - 5 °C; 12 h, reflux

参考文献：

Synthesis of some novel fused imidazo[2,1-b][1,3]thiazole and imidazo[2,1-b]thiazolo[5,4-d]isoxazole derivatives

Jaberi, Hamid Reza; Noorizadeh, Hadi, Journal of Chemistry, 2012, 9(3), 1518-1525

合成路线：1 步

_85%