944560-99-0 (HO-PEG6-Propyne,Propargyl-PEG6-alcohol)

_82%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ; 30 min, rt
1.2 Solvents: Toluene , Tetrahydrofuran ; 20 h, rt

参考文献：

Low Fouling Electrospun Scaffolds with Clicked Bioactive Peptides for Specific Cell Attachment

Rodda, Andrew E.; Ercole, Francesca; Glattauer, Veronica; Gardiner, James; Nisbet, David R.; et al, Biomacromolecules, 2015, 16(7), 2109-2118

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; reflux

参考文献：

Synthesis and anticancer activity of glucosylated podophyllotoxin derivatives linked via 4β-triazole rings

Zi, Cheng-Ting; Xu, Feng-Qing; Li, Gen-Tao; Li, Yan; Ding, Zhong-Tao; et al, Molecules, 2013, 18(11), 13992-14012

合成路线：1 步

_55%

参考文献：

Antibody-drug conjugates comprising anti-B7-H3 antibodies

, World Intellectual Property Organization, , ,

合成路线：1 步

_55%

参考文献：

Preparation of glycosides comprising cleavable linker and uses thereof as β-galactosidase inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_55%

参考文献：

Preparation of glycosides comprising cleavable linker and uses thereof as bioconjugate drugs

, World Intellectual Property Organization, , ,

合成路线：1 步

_55%

参考文献：

Preparation of glycopeptides comprising cleavable linker and uses thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_54%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 0 °C; 15 min, 0 °C
1.2 Solvents: Toluene ; 0 °C; 0 °C → rt; 3 h, rt

参考文献：

Methods and compositions for protein labeling with fluorine 18

, World Intellectual Property Organization, , ,

合成路线：1 步

_54%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 0 °C; 15 min, 0 °C
1.2 Solvents: Toluene ; 0 °C; 0 °C → rt; 3 h, rt

参考文献：

A Modular Platform for the Rapid Site-Specific Radiolabeling of Proteins with 18F Exemplified by Quantitative Positron Emission Tomography of Human Epidermal Growth Factor Receptor 2

Gill, Herman S.; Tinianow, Jeff N.; Ogasawara, Annie; Flores, Judith E.; Vanderbilt, Alexander N.; et al, Journal of Medicinal Chemistry, 2009, 52(19), 5816-5825

合成路线：1 步

_52%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide , Tetrahydrofuran ; 0 °C; 30 min, rt; rt → 0 °C
1.2 0 °C; overnight, rt

参考文献：

Pharmaceutical composition having anti-cancer immunostimulating effect and/or immune checkpoint inhibition potentiating effect

, World Intellectual Property Organization, , ,

合成路线：1 步

_52%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ; 30 min, rt
1.2 rt; overnight, rt

参考文献：

Compositions and methods for preparation of drug-antibody conjugates for cancer treatment

, World Intellectual Property Organization, , ,

合成路线：1 步

_48%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ; 0 °C → rt; overnight, rt

参考文献：

Fused heterocyclic benzodiazepine derivatives and uses thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_46%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 30 min, 0 °C
1.2 0 °C; 0 °C → rt; 20 h, rt
1.3 Reagents: Water

参考文献：

Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles

Ranjan, Nihar ; Story, Sandra; Fulcrand, Geraldine; Leng, Fenfei; Ahmad, Muzammil; et al, Journal of Medicinal Chemistry, 2017, 60(12), 4904-4922

合成路线：1 步

_37%

参考文献：

Surfaces presenting α-phenyl mannoside derivatives enable formation of stable, high coverage, non-pathogenic Escherichia coli biofilms against pathogen colonization

Zhu, Zhiling; Wang, Jun; Lopez, Analette I.; Yu, Fei; Huang, Yongkai; et al, Biomaterials Science, 2015, 3(6), 842-851

合成路线：1 步

_37%