947-84-2 (邻苯基苯甲酸,2-Phenylbenzoic acid)

_100%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Toluene ; 30 min, 105 °C; 3 h, 105 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Preparation of 4'-chloro-2-aminobiphenyl sulfate

, China, , ,

合成路线：1 步

362-59-4

_100%

反应条件：

1.1 Catalysts: Alumina ; rt → 250 °C

参考文献：

Aluminum oxide mediated C-F bond activation in trifluoromethylated arenes

Papaianina, O.; Amsharov, K. Yu., Chemical Communications (Cambridge, 2016, 52(7), 1505-1508

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Toluene ; 20 min, 115 - 120 °C; 0.5 h, 115 - 120 °C

参考文献：

Process for preparation of biphenyl-2-carboxylic acid

, China, , ,

合成路线：1 步

137600-74-9

_100%

反应条件：

1.1 Reagents: Methanol , Sodium hydride Solvents: Toluene
1.2 Solvents: Hexamethylphosphoramide
1.3 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Convenient synthesis of biphenyl-2-carboxylic acids via the nucleophilic aromatic substitution reaction of 2-methoxybenzoates with aryl Grignard reagents

Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro, Bulletin of the Chemical Society of Japan, 1993, 66(10), 3034-40

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Toluene , Water ; rt → 105 °C; 20 s, 105 °C; 105 °C → 124 °C; 1 s, 120 °C; 120 °C → 50 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 3

参考文献：

Preparation of boscalid

, China, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ; 25 °C; 1 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2

参考文献：

Preparation of boscalid intermediate 2-(4'-chlorophenyl)aniline

, China, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Toluene ; 20 min, 112 °C; 30 min, 112 °C; cooled
1.2 Reagents: Sulfuric acid Solvents: Water ; neutralized

参考文献：

Method for preparing 2-hydroxybiphenyl compounds

, China, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Sodium methoxide Catalysts: (SP-4-1)-Dibromobis[methyl 6-deoxy-6-(3-ethyl-2,3-dihydro-1H-imidazol-1-yl-κC2)-… Solvents: Water ; 15 h, 100 °C

参考文献：

Glucopyranoside-Incorporated N-Heterocyclic Carbene Complexes of Silver(I) and Palladium(II): Efficient Water-Soluble Suzuki-Miyaura Coupling Palladium(II) Catalysts

Yang, Chien-Chan; Lin, Pei-Syuan; Liu, Fu-Chen; Lin, Ivan J.-B.; Lee, Gene-Hsian; et al, Organometallics, 2010, 29(22), 5959-5971

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Palladium diacetate , Poly(oxy-1,2-ethanediyl), α-[2-(diphenylphosphino)ethyl]-ω-methoxy- Solvents: Water ; 30 min, rt
1.2 Reagents: Triethylamine ; 60 min, rt

参考文献：

Process for preparation of biaryl compounds via Suzuki cross-coupling reaction in water

, China, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium diacetate , N-(2-Methylphenyl)-P,P-diphenylphosphinous amide Solvents: Tetrahydrofuran ; 48 h, reflux

参考文献：

Preparation of phosphoramide-transition metal complex catalysts and application in formation of C-C and C-N bond

, China, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Xylene
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Preparation of biphenyl-2-carboxylic acid from fluorenone

, Japan, , ,

合成路线：1 步

_99%

参考文献：

Reactions of hydroxylamine derivatives in polyphosphoric acid

Padegimas, Stanley J., 1970, , ,

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Water ; 1.5 h, 50 °C

参考文献：

Highly Dispersed Palladium Nanoparticle-Loaded Magnetic Catalyst (FeS@EP-AG-Pd) for Suzuki Reaction in Water

Sarvi, Iraj; Gholizadeh, Mostafa; Izadyar, Mohammad, Catalysis Letters, 2017, 147(5), 1162-1171

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Calcium hydroxide , Magnesium hydroxide , Potassium hydroxide , Barium hydroxide Catalysts: L-Arginine (modified with carbon-coated iron oxide) , Iron oxide (Fe3O4) (carbon-coated, modified with arginine) , Palladium , Carbon , Copper Solvents: Water ; 1.5 h, rt

参考文献：

Highly dispersed copper/ppm palladium nanoparticles as novel magnetically recoverable catalyst for Suzuki reaction under aqueous conditions at room temperature

Lamei, Kamran ; Eshghi, Hossein ; Bakavoli, Mehdi ; Rostamnia, Sadegh, Applied Organometallic Chemistry, 2017, 31(11),

合成路线：1 步

13234-79-2

_98%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Water ; 24 h, 120 °C; 120 °C → rt
1.2 Reagents: Water ; rt

参考文献：

Palladium-Catalyzed Ortho-Arylation of Benzamides via Direct sp2 C-H Bond Activation

Li, Dan-Dan; Yuan, Ting-Ting; Wang, Guan-Wu, Journal of Organic Chemistry, 2012, 77(7), 3341-3347

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Diphenyl ether ; 6 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1 - 2

参考文献：

A process for preparing 2-aminobiphenyl derivatives

, China, , ,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Methanol , Water ; rt; 8 h, 80 °C
1.2 Reagents: Potassium carbonate Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: 1,4-Dioxane , Water ; 12 h, 100 °C
1.3 Reagents: Lithium hydroxide Solvents: Methanol , Tetrahydrofuran , Water ; 8 h, 70 °C; 70 °C → rt
1.4 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Mechanochemical-Cascaded C-N Cross-Coupling and Halogenation Using N-Bromo- and N-Chlorosuccinimide as Bifunctional Reagents

Bera, Shyamal Kanti; Mal, Prasenjit, Journal of Organic Chemistry, 2021, 86(20), 14144-14159

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Silica ; 25 min, 80 °C

参考文献：

Copper-Functionalized Silica-Coated Magnetic Nanoparticles for an Efficient Suzuki Cross-Coupling Reaction

Sonei, Samin; Taghavi, Faezeh; Khojastehnezhad, Amir ; Gholizadeh, Mostafa, ChemistrySelect, 2021, 6(3), 359-368

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium , 2-Hydroxy-3-(trimethylammonio)propyl cellulose ether chloride Solvents: Dimethylformamide ; 4 h, 110 °C

参考文献：

Cationic cellulose nanofibrils as a green support of palladium nanoparticles: catalyst evaluation in Suzuki reactions

Jebali, Zayneb; Granados, Albert; Nabili, Abdelkader; Boufi, Sami; do Rego, Ana Maria B.; et al, Cellulose (Dordrecht, 2018, 25(12), 6963-6975

合成路线：1 步

639-58-7

_96%