95332-26-6 (2-羟基-4-(甲氧基甲氧基)苯甲醛,Benzaldehyde, 2-hydroxy-4-(methoxymethoxy)-)

_96%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; overnight, rt
1.2 Reagents: Water

参考文献：

Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists

Rikimaru, Kentaro; Wakabayashi, Takeshi; Abe, Hidenori; Tawaraishi, Taisuke; Imoto, Hiroshi; et al, Bioorganic & Medicinal Chemistry, 2012, 20(10), 3332-3358

合成路线：1 步

_86%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 4 h, rt

参考文献：

The first total synthesis of phebaclavin A and C

Zhang, Yu; Liu, Dong; Li, Yang; Cao, Xiao-Ping, Chinese Journal of Chemistry, 2005, 23(10), 1453-1456

合成路线：1 步

_84%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 24 h, rt

参考文献：

Synthesis of 6-methoxy-1-oxaspiro[4.5]deca-6,9-dien-8-one

Plourde, Guy L.; Fisher, Benjamin B., Molecules [online computer file], 2002, 7(2), 315-319

合成路线：1 步

13057-17-5

_83%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane ; 0 °C; 0 °C → rt; 12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified, rt

参考文献：

Tandem Claisen Rearrangement/6-endo Cyclization Approach to Allylated and Prenylated Chromones

Schmidt, Bernd; Riemer, Martin; Schilde, Uwe, European Journal of Organic Chemistry, 2015, 2015(34), 7602-7611

合成路线：1 步

3188-13-4

_81%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 5 h, rt

参考文献：

Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B

Wang, Zengtao; Liu, Zhiguo; Lee, Woojung; Kim, Su-Nam; Yoon, Goo; et al, Bioorganic & Medicinal Chemistry Letters, 2014, 24(15), 3337-3340

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; rt; 3 h, rt → reflux

参考文献：

Total synthesis of (+)-rutamarin

Zhang, Yi-Nan; Zhang, Shi-Lei; Ma, Lei; Zhang, Yu; Shen, Xu; et al, Advanced Synthesis & Catalysis, 2008, 350, 2373-2379

合成路线：1 步

3970-21-6

_81%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane ; 5 min, rt; overnight, rt

参考文献：

Inhibitors of DNA polymerase β: Activity and mechanism

Gao, Zhijie; Maloney, David J.; Dedkova, Larisa M.; Hecht, Sidney M., Bioorganic & Medicinal Chemistry, 2008, 16(8), 4331-4340

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 0 °C; 1 h, 0 °C; 0 °C → rt; 24 h, rt
1.2 Solvents: Water ; 0 °C

参考文献：

Total Synthesis of Caesalpinnone A

Liu, Zhigang; Meng, Yifei; Yuan, Pengrui; Wang, Zhengshen; Gao, Jin-Ming ; et al, Organic Letters, 2020, 22(2), 520-522

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane ; 0 °C; 15 min, 0 °C
1.2 16 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Diethyl ether , Water

参考文献：

Preparation of [(biphenylyl)butenynyl]benzoates and analogs as retinoid receptor ligands

, European Patent Organization, , ,

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 0 °C; 2 h, reflux; reflux → rt

参考文献：

Synthesis and biological activity of flavane derivatives

He, Lan; Kong, E-Jing; Liu, Yu-Mei; An, Yu; Zhang, Wen-Sheng; et al, Chinese Journal of Chemistry, 2006, 24(3), 401-408

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 0 °C; 0 °C → rt; 28 h, rt

参考文献：

A chiral pool approach for asymmetric syntheses of both antipodes of equol and sativan

Yalamanchili, Chinni; Chittiboyina, Amar G.; Chandra Kumar Rotte, Sateesh; Katzenellenbogen, John A.; Helferich, William G.; et al, Tetrahedron, 2018, 74(16), 2020-2029

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; cooled; 1 h, 0 °C; 0 °C → rt; 24 h, rt

参考文献：

Biomimetic Syntheses and Antiproliferative Activities of Racemic, Natural (-), and Unnatural (+) Glyceollin I

Khupse, Rahul S.; Sarver, Jeffrey G.; Trendel, Jill A.; Bearss, Nicole R.; Reese, Michael D.; et al, Journal of Medicinal Chemistry, 2011, 54(10), 3506-3523

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; cooled; 1 h, 0 °C; 0 °C → rt; 24 h, rt

参考文献：

Methods for synthesizing glycinols, glyceollins I and II, compositions of selected intermediates, and therapeutic uses thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_71%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 0 °C; 6 h, rt

参考文献：

Novel thiazolidinedione derivatives with anti-obesity effects: Dual action as PTP1B inhibitors and PPAR-γ activators

Bhattarai, Bharat Raj; Kafle, Bhooshan; Hwang, Ji-Sun; Ham, Seung Wook; Lee, Keun-Hyeung; et al, Bioorganic & Medicinal Chemistry Letters, 2010, 20(22), 6758-6763

合成路线：1 步

13057-17-5

_66%