954-81-4 (N-(5-溴戊基)邻苯二甲酰亚胺,N-(5-Bromopentyl)phthalimide)

_98%

参考文献：

Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma

Ghedira, Donia; Voissiere, Aurelien; Peyrode, Caroline; Kraiem, Jamil; Gerard, Yvain; et al, European Journal of Medicinal Chemistry, 2018, 158, 51-67

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 24 h, 50 °C

参考文献：

Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors

Soliman, Beatrice; Wang, Ning; Zagotto, Giuseppe ; Pockes, Steffen, Archiv der Pharmazie (Weinheim, 2019, 352(9),

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Benzyltriethylammonium chloride Solvents: Acetone ; 24 h, rt

参考文献：

Novel Multitarget Directed Triazinoindole Derivatives as Anti-Alzheimer Agents

Patel, Dushyant V.; Patel, Nirav R.; Kanhed, Ashish M.; Patel, Sagar P.; Sinha, Anshuman; et al, ACS Chemical Neuroscience, 2019, 10(8), 3635-3661

合成路线：1 步

_88%

反应条件：

1.1 Solvents: Acetone ; rt → 60 °C; 7 h, 60 °C

参考文献：

N-alkylated o-benzene dicarboximido piperazine derivative and its synergistic composition

, China, , ,

合成路线：1 步

_88%

反应条件：

1.1 Solvents: Acetone ; rt → 63 °C; 7.2 h, 63 °C

参考文献：

N-alkylated phthalimide piperazine derivative and its preparation method and application as arthropodicide in prevention and control of invertebrate pests

, China, , ,

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 16 h, rt

参考文献：

Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD

Liu, Anqiu; Huang, Ling; Wang, Zhiren; Luo, Zonghua; Mao, Fei; et al, Bioorganic & Medicinal Chemistry Letters, 2013, 23(5), 1548-1552

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ; 24 h, reflux

参考文献：

Synthesis and biological evaluation of coumarin linked fluoroquinolones, phthalimides and naphthalimides as potential DNA gyrase inhibitors

Kamal, A.; Satyanarayana, M.; Devaiah, V.; Rohini, V.; Yadav, J. S.; et al, Letters in Drug Design & Discovery, 2006, 3(7), 494-502

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Tetrabutylammonium bromide Solvents: Acetonitrile ; 4 h, rt → reflux

参考文献：

Synthesis and Bioevaluation of Novel [18F]FDG-Conjugated 2-Nitroimidazole Derivatives for Tumor Hypoxia Imaging

Yang, Xianteng; Wang, Fan; Zhu, Hua; Yang, Zhi ; Chu, Taiwei, Molecular Pharmaceutics, 2019, 16(5), 2118-2128

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Acetone ; 12 h, 25 °C

参考文献：

Organic long afterglow compounds, and preparation method and application thereof in four-dimensional encoding for realizing storage of large amount of information and information encryption

, China, , ,

合成路线：1 步

_82%

反应条件：

1.1 Solvents: Acetone ; 30 min, rt; 30 min, rt; rt → 60 °C; 15 h, 60 °C

参考文献：

Preparation of peptide conjugates as IRAK4 protein kinase degraders

, United States, , ,

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ; 24 h, reflux

参考文献：

Radiosynthesis and evaluation of novel 99mTc(CO)3-labelled thymidine dithiocarbamate derivatives for tumor imaging with SPECT

Duan, Xiaojiang ; Ruan, Qing; Gan, Qianqian; Song, Xiaoqing; Fang, Si'an; et al, Journal of Organometallic Chemistry, 2018, 868, 154-163

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 12 h, reflux

参考文献：

Synthesis of 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine

Tan, Wei-qiang; Meng, Guang-ning; Wang, Li; Lu, Li-li; Xia, Yan, Huaxue Shiji, 2015, 37(10), 929-931

合成路线：1 步

63273-48-3

_80%

反应条件：

1.1 Reagents: N-Bromosuccinimide , Tetraphenylporphyrin Solvents: Dichloromethane ; 10 min, 0 °C; 3 h, 0 °C

参考文献：

Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases

Thomson, Andrew; O'Connor, Sean; Knuckley, Bryan; Causey, Corey P., Bioorganic & Medicinal Chemistry, 2014, 22(17), 4602-4608

合成路线：1 步

90667-53-1

_78%