NG-单甲基-L-精氨酸乙酸盐

别名 NG-甲基-L-精氨酸 乙酸盐|Nω-甲基-L-精氨酸 乙酸盐|NG-一甲基-L-精氨酸 乙酸盐|N5-(甲基脒基)-L-鸟氨酸 乙酸盐|L-NMMA 一乙酸酯|N5-[亚氨基(甲基氨基)甲基]-L-鸟氨酸单乙酸盐
英文别名 L-NMMA acetate|Tilarginine Acetate|53308-83-1|L-NMMA|NG-Monomethyl-L-arginine acetate|NG-Methyl-L-arginine acetate salt|Targinine acetate|Tilarginine acetate [USAN]|L-NMMA (acetate)|ANO-1020|Ng-methylarginine acetate|N-Omega-monomethyl-L-arginine acetate|
规格或纯度 10mM in Water
英文名称 NG-Monomethyl-L-arginine Acetate 生化机理 细胞渗透性竞争性NOS抑制剂。（对于eNOS，iNOS和nNOS，K i值分别为700 nM，3.9 µM和650 nM）。
储存温度 -80℃储存
运输条件 超低温冰袋运输
产品介绍 L-NG-Monomethylarginine, Acetate Salt (L-NMMA), is an analogue of L-arginine that has been shown to inhibit Ca2+-dependent NOS3 (endothelial NOS) from porcine aorta. In an experiment on porcine aortic rings, L-NMMA was shown to cause contraction and inhibition of the endothelium-dependent relaxation induced by acetylcholine. This compound has also been noted to elicit a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Experiments on cat vascular endothelia show that L-NMMA can increase leukocyte adherence and emigration and reduce venular shear rate. Low shear rates have been shown to promote platelet-endothelial and leukocyte-endothelial cell adhesion in mesenteric venules. L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an inhibitor of NOS1 and NOS2. L-NG-Monomethylarginine, Acetate Salt (L-NMMA), is an analogue of L-arginine that has been shown to inhibit Ca2+-dependent NOS3 (endothelial NOS) from porcine aorta. In an experiment on porcine aortic rings, L-NMMA was shown to cause contraction and inhibition of the endothelium-dependent relaxation induced by acetylcholine. This compound has also been noted to elicit a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Experiments on cat vascular endothelia show that L-NMMA can increase leukocyte adherence and emigration and reduce venular shear rate. Low shear rates have been shown to promote platelet-endothelial and leukocyte-endothelial cell adhesion in mesenteric venules. L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an inhibitor of NOS1 and NOS2. An L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS)