SB525334,TGFBR1抑制剂

别名 6-[2-(叔丁基)-5-(6-甲基吡啶-2-基)-1H-咪唑-4-基]喹喔啉
英文别名 356559-20-1|SB-525334|SB 525334|SB525334|6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline|6-[2-TERT-BUTYL-5-(6-METHYL-PYRIDIN-2-YL)-1H-IMIDAZOL-4-YL]-QUINOXALINE|MFCD11045307|CHEMBL401570|6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-
规格或纯度 ≥98%
英文名称 SB525334 生化机理 TGF-β RI Kinase Inhibitor VIII is a cell-permeable quinoxaline compound that acts as a potent, highly selective, ATP-competitive inhibitor against type I TGF-β receptor TβR-I/ALK5 (IC50 = 14.3 nM), while exhibiting 4-fold less potency toward ALK4 (IC50 = 58.5 nM) and little or no activity against ALK2/3/6 and a panel of 26 other commonly studied kinases (≤29% inhibition at 10 μM). TGF-β RI Kinase Inhibitor VIII effectively blocks (by >95%) TGF-β1-induced Smad2/3 activation (2 μM in ELT-3 cultures) and nuclear localization (1 μM in RPTE cultures), as well as TGF-β1-dependent p3TP- and ARE-luciferase transcription (0.1 μM in HaCat cultures). TGF-β RI Kinase Inhibitor VIII is an inhibitor of ACTR-IB, COL1A1(procollagen α1(I)) and PAI-1(plasminogen activator inhibitor-1).
储存温度 2-8°C储存
运输条件 冰袋运输 备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍 SB525334是一种有效的，选择性的TGFβ receptor I (ALK5)抑制剂，IC50为14.3 nM，作用于ALK4比作用于ALK5效果低4倍，可抑制ALK2， 3，和6活性。A potent ATP-competitive inhibitor against receptor TbR-I/ALK5. SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. A potent ATP-competitive inhibitor against receptor TbR-I/ALK5.