微囊藻毒素Microcystin-LA

英文别名 Microcystin-LA|Cyanoginosin LA|Microcystin LA|96180-79-9|MC-LA|Microcystin-leucine-alanine|Toxin BE 4 (Microcystis aeruginosa)|Cyanoginosin-LA|3E7C54U3SY|CHEMBL421377|(5R,8S,11R,12S,15S,18S,19S,22R)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1
规格或纯度 10ug/ml in methanol
英文名称 Microcystin-LA 生化机理 微囊藻毒素 LA 抑制蛋白磷酸酶类型 A 型和蛋白磷酸酶 3 类型的能力强于蛋白磷酸酶 1 类型（效价顺序 PP2A > PP3 > PP1）。诱导中性粒细胞活化趋化因子和胞外活性氧，可能的机制是其肝毒性作用。 应用 Microcystin LA 是一种天然毒素，Microcystin LA 通过抑制丝氨酸-苏氨酸蛋白磷酸酶 PP1 (IC50=0.3 nM) 和 PP2A (IC50=0.3 nM) 来发挥其细胞毒性作用。
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍
产品介绍： 微囊藻毒素是一种单环小分子多肽，由 7 个氨基酸通过肽键连接而成。是一种具有肝毒性和促癌属性的青毒素。鱼腥藻属、 丝囊藻属、 微胞藻属 和 浮丝藻属等几个藻属产生微囊藻毒素。微囊藻毒素有四种同源物，即-LR、-LA、-YR 和-RR。 产品用途： Microcystin LA inhibit PP1 and PP2A quite potently and specifically relative to other known phosphatases, such as PP2B (calcineurin), PP2C, and the tyrosine phosphatases Product introduction: Microcystin is a small, monocyclic peptide, composed of seven amino acids connected via peptide bonds. It is a cyanotoxin with hepatotoxic and tumor promoting properties. Several algal genera like Anabaena, Aphanizomenon, Microcystis and Planktothrix produce microcystin.[2] Microcystin has four congeners namely, -LR, -LA, -YR and -RR. Application： Microcystin LA inhibit PP1 and PP2A quite potently and specifically relative to other known phosphatases, such as PP2B (calcineurin), PP2C, and the tyrosine phosphatases