CAS:1849590-01-7|6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione

产品货号：A629153
产品名称：6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione
Synonyms:eFT508
CAS号：1849590-01-7
分子式：C₁₇H₂₀N₆O₂
Appearance:Pale Yellow Solid
Melting Point:>300°C
分子量：340.38
Storage:4°C, Inert atmosphere
Solubility:DMSO (Slightly, Heated), Methanol (Very Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用：6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione was used in the study of inhibitors of immune checkpoint modulators and related methods. eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor.
参考文献：Webster, K., et al.: U.S. Pat. Appl. Publ. (2016), US 20160303124 A1 20161020; Webster, K., et al.: Blood, 126, 1554 (2015);
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