2. Neuronal Signaling GPCR/G Protein
  3. Monoamine Oxidase 5-HT Receptor
  4. 5,7-Dihydroxytryptamine

5,7-Dihydroxytryptamine (5,7-DHT) 是一种自发荧光、选择性神经毒素，是 MAO-A、5-HT 的转运底物。5,7-Dihydroxytryptamine 可特异性靶向并损毁中枢及外周的 5-HT 能神经元，同时影响 5-HT 相关通路及神经递质平衡。5,7-Dihydroxytryptamine 可用于构建 5-HT 能神经元损伤模型，用于研究神经发育、神经退行性疾病，以及血小板功能和视网膜神经元相关机制。

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5,7-Dihydroxytryptamine

5,7-Dihydroxytryptamine Chemical Structure

CAS No. : 31363-74-3

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Other Forms of 5,7-Dihydroxytryptamine:

5,7-Dihydroxytryptamine 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

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MAO-A MAO-B

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5,7-Dihydroxytryptamine (5,7-DHT) is an autofluorescent, selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons[1][2][3].

IC50 & Target

MAO-A

 

体外研究
(In Vitro)

5,7-dihydroxytryptamine (25 μM；37℃; 60 min) 可特异性标记取自 14 日龄 Wistar 大鼠胎鼠的 10 日龄原代中脑培养物中的 5-羟色胺能细胞 (但不标记多巴胺能细胞)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5,7-Dihydroxytryptamine 相关抗体:
体内研究
(In Vivo)

5,7-Dihydroxytryptamine (12.5-50.0 μg；脑室内给药；单剂量) 可耗尽小鼠海马体中的去甲肾上腺素和 5-HT，其中去甲肾上腺素的耗竭可被非选择性 MAO 抑制作用阻断，但无法被选择性 MAO-B 抑制作用阻断[1]。
5,7-Dihydroxytryptamine (10 µg 碱基；侧脑室注射；单次给药；惊厥诱导前 10 天) 可耗竭大鼠脊髓中的 5-HT 水平，但不影响电诱导的大鼠脊髓惊厥[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 male mice (2 months old, 20-30 g)[1]
Dosage: 12.5, 25, 50.0 μg
Administration: intracerebroventricularly; single dose
Result: Depleted hippocampal norepinephrine by 68% and serotonin by 71% in mice not pretreated with MAO inhibitors.
Animal Model: Sprague-Dawley (female, 180-220 g)[3]
Dosage: 10 µg of the base
Administration: i.c.v.; single dose; 10 days before seizure induction
Result: Reduced spinal cord 5-hydroxytryptamine levels to 0.21 µg/g ± 0.04; produced no changes in spinal cord norepinephrine content or electrically-induced spinal cord seizure parameters (duration of tonic flexion, tonic extension, or total seizure duration)
分子量

192.21

Formula

C10H12N2O2
CAS 号
结构分类
初始来源

rat
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5,7-Dihydroxytryptamine 相关分类

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Keywords:

5,7-Dihydroxytryptamine31363-74-35,7-DHPMonoamine Oxidase5-HT ReceptorMAOSerotonin Receptor5-hydroxytryptamine Receptorspinal cord 5-hydroxytryptamineMonoamine oxidase A (MAO A)C57BL/6 miceserotonin transporterhippocampal serotoninserotonergic neuronehippocampal norepinephrinenoradrenergic neuroneWistar rat foetusescentral nervous system 5-hydroxytryptaminergic neuroneInhibitorinhibitorinhibit

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