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Substrate

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2309

抑制剂 & 激动剂

化合物筛选库

197

荧光染料

406

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681

多肽产品

MCE 试剂盒

抗体抑制剂

245

天然产物

重组蛋白

同位素标记物

抗体

点击化学

寡核苷酸

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Targets Recommended: MARCKS

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-P5990

Prostate Specific Antigen Substrate	PSMA	Cancer
Prostate Specific Antigen Substrate 是前列腺特异性抗原 (PSA) 荧光底物。Prostate Specific Antigen Substrate 可用于检测 PSA 酶活性。

HY-P2498A

*Cathepsin D and E FRET Substrate* acetate**	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate 为 cathepins D 和 E 的荧光底物 (fluorogenic substrate)，而不是 B、H 或 I 的荧光底物，它的裂解发生在 Phe-Phe 酰胺键处。Cathepsin D and E FRET Substrate 是用于组织蛋白酶 D 和组织蛋白酶 E 的常规检测和机制研究的有用工具。(激发波长:328 nm; 发射波长:393 nm)

HY-P10050

Calpain substrate	Proteasome	Others
Calpain substrate 是膜不透性荧光钙蛋白酶底物，可用于钙蛋白酶酶活性测定。

HY-170462

CSPD substrate	Biochemical Assay Reagents	Others
CSPD 显色底物 CSPD substrate 是碱性磷酸酶的化学发光底物。CSPD substrate 提供增强的碱性磷酸酶敏感性和更简化的检测。

HY-P2414

MMP-13 Substrate	MMP	Inflammation/Immunology
MMP-13 Substrate 是 MMP-13 的底物。MMP-13 Substrate 可用于骨关节炎 (OA) 的研究。

HY-P2498

Cathepsin D and E FRET Substrate	Cathepsin	Others
Cathepsin D and E FRET Substrate 为 cathepins D 和 E 的荧光底物 (fluorogenic substrate)，而不是 B、H 或 I 的荧光底物，它的裂解发生在 Phe-Phe 酰胺键处。Cathepsin D and E FRET Substrate 是用于组织蛋白酶 D 和组织蛋白酶 E 的常规检测和机制研究的有用工具。(激发波长:328 nm; 发射波长:393 nm)

HY-P2414A

*MMP-13 Substrate* TFA**	MMP	Inflammation/Immunology
MMP-13 Substrate TFA 是 MMP-13 的底物。MMP-13 Substrate TFA 可用于骨关节炎 (OA) 的研究。

HY-P3944

Calmodulin Dependent Protein Kinase Substrate	CaMK	Neurological Disease
Calmodulin Dependent Protein Kinase Substrate 是一种 Ca²⁺- 和钙调蛋白 (CaM) 依赖性蛋白激酶 (CaMK) 底物肽。Calmodulin Dependent Protein Kinase Substrate 是一种合成蛋白激酶的肽底物。

HY-P3934

*HIV Protease Substrate* I**	HIV Protease	Infection
HIV Protease Substrate I 是 HIV-1 蛋白酶的显色底物。HIV Protease Substrate I 具有 HIV 蛋白酶的裂解位点。

HY-P3943

*Calmodulin Dependent Protein Kinase Substrate* Analog**	CaMK	Neurological Disease
Calmodulin Dependent Protein Kinase Substrate Analog 是一种 Ca²⁺- 和钙调蛋白 (CaM) 依赖性蛋白激酶 (CaMK) 底物肽。Calmodulin Dependent Protein Kinase Substrate Analog 是一种合成蛋白激酶的肽底物。

HY-P3815

*Casein Kinase 2 Substrate* Peptide** 2 篇文献验证	Casein Kinase	Others
Casein Kinase 2 Substrate Peptide 是一种常见的 CK2 底物肽。Casein Kinase 2 Substrate Peptide 的 C 端与 5-[(2-氨基乙基)氨基]萘-1-磺酸 (EDANS) 结合。Casein Kinase 2 Substrate Peptide 可用于蛋白激酶 CK2 活性的测定。

HY-P4018

*HIV Protease Substrate* IV**	HIV Protease	Infection
HIV Protease Substrate IV 是 HIV 蛋白酶的底物。 HIV Protease Substrate IV 可用于检测 HIV (人类免疫缺陷病毒)-1 蛋白酶的活性。

HY-P1344

*DAPK Substrate* Peptide**	DAPK	Cancer
DAPK Substrate Peptide 是一种合成的死亡相关蛋白激酶 (DAPK) 的肽底物， K_m 为 9 μM。

HY-P10043

MMP-1 Substrate	MMP	Others
MMP-1 Substrate 是一种基质金属蛋白酶-1 (MMP-1) 选择性底物，可用于 MMP-1 酶活性的荧光测定。

HY-P10609

*Btk substrate* peptide**	Btk	Others
Btk substrate peptide 是一种人类 Bruton’s tyrosine kinase (Btk) 残基 217-229 相对应的肽底物，其中残基 223 的酪氨酸是 Btk 的主要自磷酸化位点。Btk substrate peptide 作为底物用于体外激酶测定，以评估 Btk 或其他酪氨酸激酶的活性。

HY-P1344A

*DAPK Substrate* Peptide TFA**	DAPK	Cancer
DAPK Substrate Peptide TFA 是一种合成的死亡相关蛋白激酶 (DAPK) 的肽底物， K_m 为 9 μM。

HY-P3948

*Fluorescent Substrate* for Pro-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Pro-Specific Proteases 是 Pro-Specific 蛋白酶的荧光底物。Fluorescent Substrate for Pro-Specific Proteases 可用于检测靶标酶的水解速率和活性。

HY-P3921

Casein Kinase II Substrate	Casein Kinase	Cancer
Casein Kinase II Substrate 是一种酪蛋白激酶 II (CK2) 肽底物，可被 CK2 选择性磷酸化。

HY-P3771

*p60c-src substrate* II, phosphorylated**	Src	Others
p60c-src substrate II，phosphorylated 是一种五肽。p60c-src substrate II，phosphorylated 是 p60c-src substrate II 磷酸化多肽。蛋白质磷酸化是蛋白质翻译后的重要修饰，在生物调控中不可或缺。

HY-P3949

*Fluorescent Substrate* for Glu-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Glu-Specific Proteases 是一种 V8 蛋白酶特异性显色底物。

HY-P10189

*α-Secretase Substrate, Fluorogenic*	Biochemical Assay Reagents	Others
α-Secretase Substrate, Fluorogenic 是 α-分泌酶荧光底物，可用于测试 α-分泌酶活性。

HY-P10073

*Calpain-1 substrate, fluorogenic*	Fluorescent Dye	Others
Calpain-1 substrate, fluorogenic 可以作为 calpain-1 的敏感且特异的底物，可裂解 Tyr-Gly 键并导致荧光增强。(Ex/Em = 490 nm/518 nm)

HY-P3743

p60c-src Substrate	Src Others	Others
p60c-src Substrate 是一种高效特异性的 p60c-src 蛋白酪氨酸激酶 (PTK) 的底物。p60c-src Substrate 可用于合成嵌合支化多肽。

HY-P10042A

*S6K Substrate* acetate**	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate acetate 是活性蛋白激酶的底物，包括 CLK2、MRCKalpha、MRCKbeta、p70S6K、ROCK1、ROCK2、RSK1、RSK3、PIM1。

HY-P10042

S6K Substrate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate 是活性蛋白激酶的底物，包括 CLK2、MRCKalpha、MRCKbeta、p70S6K、ROCK1、ROCK2、RSK1、RSK3、PIM1。

HY-P10602

PKA Regulatory Subunit II Substrate RII phosphopeptide	PKA	Others
PKA Regulatory Subunit II Substrate (RII phosphopeptide) 是一种工具肽，来源于环磷酸腺苷依赖性蛋白激酶 (PKA) 的调节亚基 Type II (RII)。PKA Regulatory Subunit II Substrate 通常用于模拟蛋白激酶的磷酸化作用，并作为蛋白磷酸酶的特异性底物来评估这些酶的活性。

HY-P2179

*MMP-1/MMP-9 Substrate, Fluorogenic*	Fluorescent Dye MMP	Others
MMP-1/MMP-9 Substrate, Fluorogenic 是 MMP-1 和 MMP-9 的荧光底物。Ex/Em=340/440 nm。

HY-P10163

*α-Secretase Substrate* II, Fluorogenic**	Fluorescent Dye	Others
α-Secretase Substrate II, Fluorogenic 是 α-分泌酶的内部猝灭荧光肽底物，含有 β-淀粉样蛋白前体蛋白 (APP) 的 α-分泌酶切割位点。Ex/Em = 340/490 nm

HY-P3947

*Fluorescent Substrate* for Subtillsin**	Ser/Thr Protease	Infection
Fluorescent Substrate for Subtillsin 可用于检测 Subtillsin 的酶活。Subtilisin 是一种细菌丝氨酸蛋白酶。

HY-P5976

Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC Renin Substrate I	Renin	Others
Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) 是一种肾素底物。

HY-P1113A

*Phospho-Glycogen Synthase Peptide-2(substrate) TFA*	GSK-3	Others
Phospho-Glycogen Synthase Peptide-2 (substrate) 是糖原合酶激酶-3 (GSK-3) 的肽底物，可用于蛋白丝氨酸激酶的亲和纯化。

HY-P3797

Furin Substrate	Furin	Cancer
Furin Substrate 是一种多肽。Furin Substrate 可用于多种生化研究。

HY-P3814

*S6 Kinase Substrate* Peptide 32**	Ribosomal S6 Kinase (RSK)	Cancer
S6 Kinase Substrate Peptide 32 是 Ribosomal S6 Kinase (RSK) 的底物，可用来测量磷酸化核糖体蛋白 S6 的 RSKs 激酶活性。

HY-126785

Suc-AAP-Abu-pNA Colorimetric Elastase Substrate	Elastase	Others
Suc-AAP-Abu-pNA (Colorimetric Elastase Substrate) 是胰腺弹性蛋白酶的特异性底物 (K_m = 100 μM; K_cat/K_m = 35,300 s^-1 M^-1 for rat pancreatic elastase; K_m = 30 μM; K_cat/K_m = 351,000 s^-1 M^-1 for porcine pancreatic elastase)。

HY-P3878

*Renin substrate* 1**	Renin	Cardiovascular Disease
Renin substrate 1 是一种对酶具有高亲和力的肾素 (renin) 底物。

HY-P10527

CSK substrate	Src	Others
CSK substrate 是 C 端 Src 激酶 (CSK) 的特异性底物，可与 CSK 结合并下调 Src 家族成员水平。CSK substrate 优先磷酸化与保守的 Src C 末端序列不同的某些氨基酸残基。

HY-P0320

*EGF Receptor Substrate* 2 (Phospho-Tyr5)**	Phosphatase	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate，一种生物活性肽，是一种酪氨酸磷酸底物。EGF Receptor Substrate 2 (Phospho-Tyr5) acetate 可用于检测蛋白酪氨酸磷酸酶活性。

HY-155002

*hCYP3A4 Fluorogenic substrate* 1**	Cytochrome P450	Metabolic Disease
hCYP3A4 Fluorogenic substrate 1 是一种强效 hCYP3A4 荧光底物，K_m 值为 0.36 μM。hCYP3A4 Fluorogenic substrate 1 可用于细胞和体内成像。

HY-P0320A

*EGF Receptor Substrate* 2 (Phospho-Tyr5) (TFA)**	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate，一种生物活性肽，是一种酪氨酸磷酸底物。EGF Receptor Substrate 2 (Phospho-Tyr5) acetate 可用于检测蛋白酪氨酸磷酸酶活性。

HY-P0320B

*EGF Receptor Substrate* 2 (Phospho-Tyr5) (acetate)**	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate，一种生物活性肽，是一种酪氨酸磷酸底物。EGF Receptor Substrate 2 (Phospho-Tyr5) acetate 可用于检测蛋白酪氨酸磷酸酶活性。

HY-P2492

*Renin FRET Substrate* I**	Angiotensin Receptor	Metabolic Disease
Renin FRET Substrate I 是人肾素的底物。Renin FRET Substrate I 可以作为整合人血管紧张素原 N 端肽段中出现的肾素裂解位点。

HY-138653

Lipase Substrate	Lipase	Metabolic Disease
脂肪酶底物 Lipase Substrate 可用于检测脂肪酶活性。

HY-P2344

*HIV Protease Substrate* 1**	HIV Protease	Infection
HIV Protease Substrate 1 是一种外源性 HIV 蛋白酶底物，可用于研究 HIV 蛋白酶的酶活性。

HY-P1561

PKG Substrate	PKG	Neurological Disease
PKG Substrate 是一种 cGMP 依赖性的蛋白激酶 (PKG) 的选择性底物。

HY-P1906

[pThr3]-CDK5 Substrate	CDK	Neurological Disease
[pThr3]-CDK5 Substrate 是 Thr3 磷酸化的 CDK5 底物。[pThr3]-CDK5 Substrate 来自组蛋白 H1，位于组蛋白 H1 上和 CDK5 作用的位点。CDK5 Substrate 被 CDK5 磷酸化为 [pThr3]-CDK5 Substrate 的 K_m 为 6 μM。

HY-P3951

Fluorescent HIV Substrate	Fluorescent Dye HIV	Others
Fluorescent HIV Substrate 是 HIV 底物。

HY-P5965

BiP substrate	HSP	Others
BiP substrate 是 BiP 的肽底物，可用于测量 BiP ATPase 活性。

HY-P10922

*Cathepsin E substrate* e**	Cathepsin	Others
Cathepsin E substrate e 是组织蛋白酶 E 的底物。Cathepsin E substrate e 的设计方式是，由于 Mca 供体和 Dnp 受体非常接近，因此在完整状态下可实现近乎完全的分子内猝灭效应。肽底物的疏水基序被蛋白酶切割后，Mca 和 Dnp 会进一步分离，从而产生明亮的荧光。