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  3. Agelastatin D

Agelastatin D 是一种吡咯-咪唑类生物碱和细胞毒剂。Agelastatin D 可从西澳大利亚海绵 Cymbastela 属物种中分离得到。Agelastatin D 可诱导对癌细胞的细胞毒活性,可用于慢性淋巴细胞白血病的研究。

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Agelastatin D

Agelastatin D Chemical Structure

CAS No. : 201338-45-6

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  • 生物活性

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生物活性

Agelastatin D is a pyrrole-imidazole alkaloid and cytotoxic agent found in the Western Australian sponge Cymbastela sp.. Agelastatin D induces cytotoxic activity against cancer cells. Agelastatin D can be used for the research of chronic lymphocytic leukemia[1].

体外研究
(In Vitro)

Agelastatin D (compound 2b) 对 CLL1、CLL2、JVM-2 和 HeLa 细胞系表现出细胞毒活性,48 h 时的 EC50 值分别为 91.1 μM、29.0 μM、13.2 μM 和 13.7 μM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: primary chronic lymphocytic leukemia (CLL) patient cell lines (CLL1, CLL2), immortalized leukemic JVM-2 cell line, HeLa cell line
Concentration: dose-response format (CLL1, CLL2, JVM-2); dose-response format (HeLa)
Incubation Time: 48 h (CLL1, CLL2, JVM-2); overnight (HeLa)
Result: Exhibited cytotoxic activity with EC50 values of 91.1 μM (CLL1), 29.0 μM (CLL2), 13.2 μM (JVM-2), and 13.7 μM (HeLa).
分子量

327.13

Formula

C11H11BrN4O3

CAS 号
结构分类
初始来源

Cymbastela sp.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Agelastatin D
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HY-N19313
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