2. Others GPCR/G Protein Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis
  3. Reference Standards Orexin Receptor (OX Receptor) Calcium Channel Caspase Apoptosis
  4. Almorexant hydrochloride (Standard)

Almorexant hydrochloride (Standard) 是 Almorexant (hydrochloride) (HY-10805A) 的分析标准品。本产品用于研究及分析应用。Almorexant (ACT 078573) hydrochloride 是一种口服有效且竞争性的双 orexin receptor 拮抗剂，Kd 分别为 1.3 nM (OX1) 和 0.17 nM (OX2)。Almorexant hydrochloride 可逆地阻断食欲素-A 和食欲素-B 多肽信号。Almorexant hydrochloride 完全阻断细胞内 Ca2+ 信号通路。Almorexant hydrochloride 刺激 AsPC-1 细胞 caspase-3 活性，诱导细胞凋亡 (apoptosis)。

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Almorexant hydrochloride (Standard)

Almorexant hydrochloride (Standard) Chemical Structure

CAS No. : 913358-93-7

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Almorexant hydrochloride (Standard) 相关抗体

Top Publications Citing Use of Products

查看 Orexin Receptor (OX Receptor) 亚型特异性产品:

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OX2 Receptor OX1 Receptor

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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生物活性

Almorexant hydrochloride (Standard) is the analytical standard of Almorexant (hydrochloride) (HY-10805A). This product is intended for research and analytical applications. Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1][2][3][4].

IC50 & Target

Kd: 0.17 nM (hOX2), 1.3 nM (hOX1)[2]
分子量

549.02

Formula

C29H32ClF3N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Almorexant hydrochloride (Standard) 相关分类

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Keywords:

Almorexant hydrochloride (Standard)913358-93-7Reference StandardsOrexin Receptor (OX Receptor)Calcium ChannelCaspaseApoptosisHypocretin ReceptorHCRT ReceptorCa2+ channelsCa channelsAsPC-1 cellsHPAF-II cellsPancreatic ductal adenocarcinomaPDACGPCRapoptosispancreatic cancernarcolepsyorexinhypocretinCataplexyInhibitorinhibitorinhibit

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