2. Anti-infection
  3. Antibiotic Bacterial
  4. Antibiotic adjuvant 5

Antibiotic adjuvant 5 (Compound 2) 是一种抗生素 (Antibiotic) 佐剂。Antibiotic adjuvant 5 能够增强 Azithromycin (HY-17506)、Clarithromycin (HY-17508)、Doripenem (HY-B0187) 和 Rifampin (HY-B0272) 对铜绿假单胞菌 PAO1 的活性。Antibiotic adjuvant 5 与 Azithromycin 联合使用时，可提高铜绿假单胞菌 PAO1 感染期间大蜡螟的存活率。Antibiotic adjuvant 5 可用于铜绿假单胞菌感染的研究。

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Antibiotic adjuvant 5

Antibiotic adjuvant 5 Chemical Structure

CAS No. : 2292113-87-0

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Antibiotic adjuvant 5 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibiotic adjuvant 5 (Compound 2) acts as an Antibiotic adjuvant. Antibiotic adjuvant 5 enhances the activity of Azithromycin (HY-17506), Clarithromycin (HY-17508), Doripenem (HY-B0187) and Rifampin (HY-B0272) against *Pseudomonas aeruginosa* PAO1. When used in combination with Azithromycin, Antibiotic adjuvant 5 increases the survival rate of *Galleria mellonella* during *Pseudomonas aeruginosa* PAO1 infection. Antibiotic adjuvant 5 is applicable for the research of *Pseudomonas aeruginosa* infection[1].

体外研究
(In Vitro)

Antibiotic adjuvant 5 (60 μM; 16 h) 可呈剂量依赖性增强 Azithromycin 对铜绿假单胞菌 PAO1 的活性，使 Azithromycin 的 MIC 最大降低 1024 倍[1]。
Antibiotic adjuvant 5 (60 μM; 1 h) 可使铜绿假单胞菌 PAO1 的膜通透性在 60 μM 时提升 50%[1]。
Antibiotic adjuvant 5 (16 h) 在极低盐培养基中可将 Azithromycin 对铜绿假单胞菌 PAO1 的活性增强 512 倍[1]。
Antibiotic adjuvant 5 (60μM; 16 h) 可增强 Clarithromycin、Doripenem 和 Rifampin 对铜绿假单胞菌 PAO1 的活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibiotic adjuvant 5 相关抗体:
体内研究
(In Vivo)

Antibacterial agent 335 (50-400 mg/kg；注射；单次) 与 50 mg/kg Azithromycin 联合使用时，可使感染 Pseudomonas aeruginosa PAO1 的 Galleria mellonella 的存活率达到 43%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: greater wax moth larvae (weight 200-300 mg)[1]
Dosage: 50 mg/kg (alone); 50 mg/kg (in combination with 50 mg/kg azithromycin); 400 mg/kg (alone)
Administration: injection; single dose
Result: Did not improve survival compared to untreated, infected larvae.
Achieved a 43% survival rate after 6 days when combined with 50 mg/kg azithromycin.
Resulted in 100% larval survival after 6 days at 400 mg/kg.
分子量

235.29

Formula

C10H17N7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibiotic adjuvant 5 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antibiotic adjuvant 52292113-87-0Antibiotic adjuvant5Antibiotic adjuvant-5AntibioticBacterialdoripenemFe(II)sheep blood cellsMn(II)azithromycinrifampincystic fibrosis-associated Pseudomonas aeruginosa isolatesclarithromycinGalleria mellonellaPseudomonas aeruginosa PAO1Inhibitorinhibitorinhibit

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