S1P1/EDG1 抗体 (YA3874)

目录号: HY-P84177 一键复制产品信息: Data Sheet SDS COA 抗体使用指南
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S1P1/EDG1 Antibody (YA3874) 是一个小鼠来源、无偶联标记、抗 S1P1/EDG1 的 IgG2a 单克隆抗体。

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规格	价格	是否有货
20 μL	￥950	In-stock
50 μL	￥1575	In-stock
100 μL	￥2520	In-stock
250 μL		询价

or 大包装询价

* Please select Quantity before adding items.

WB: 蛋白质免疫印迹;
IHC-P: 石蜡切片样本的免疫组织化学;
IHC-F: 冰冻切片样本的免疫组织化学;
ICC/IF: 细胞免疫荧光;
IF-Tissue: 组织免疫荧光;
mIHC: 多重荧光免疫组化;
IP: 免疫沉淀;
ChIP: 染色质免疫沉淀;
FC: 流式细胞术;
ELISA: 酶联免疫吸附试验

产品详情
验证图片
背景信息
产品资料

描述

S1P1/EDG1 Antibody (YA3874) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to S1P1/EDG1.

宿主

Mouse

克隆性

Monoclonal

分子量

Predicted band size: 43 kDa;

Observed band size: 43 kDa

请注意：因蛋白存在修饰或聚体等情况，以实测为准，预测仅为参考。

反应种属

Human

蛋白数据库

P21453

基因 ID

1901 [NCBI]

免疫原

Purified recombinant fragment of human CD363 expressed in E. Coli.

应用 & 推荐
稀释比例

应用	稀释比
WB WB: 蛋白质免疫印迹	1:500-1:2000
IHC-P IHC-P: 石蜡切片样本的免疫组织化学	1:200-1:1000
FC FC: 流式细胞术	1:200-1:400
ELISA ELISA: 酶联免疫吸附试验	1:10000

纯度	affinity purified.	偶联	Non-conjugated
修饰	Unmodified	同型	IgG2a

性状

液体

组分

Supplied in PBS with 0.05% sodium azide

保存条件 & 期限

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

运输条件

Shipping with blue ice.

验证图片

IHC

Immunohistochemical analysis of paraffin-embedded human Colon cancer tissue using S1P1/EDG1 antibody was performed. The section was pretreated using high-temperature and high-pressure mediated EDTA antigen retrieval buffer (pH 9.0), for 5 minutes. The tissues were incubated with primary antibody (HY-P84177, 1:50 dilution) at room temperature for 60 minutes. Detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. The tissues were counterstained with hematoxylin and mounted with neutral balsam mounting medium.
Immunohistochemical analysis of paraffin-embedded human Colon cancer tissue using S1P1/EDG1 antibody was performed. The section was pretreated using high-temperature and high-pressure mediated EDTA antigen retrieval buffer (pH 9.0), for 5 minutes. The tissues were incubated with primary antibody (HY-P84177, 1:50 dilution) at room temperature for 60 minutes. Detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. The tissues were counterstained with hematoxylin and mounted with neutral balsam mounting medium.
Immunohistochemical analysis of paraffin-embedded human Liver cancer tissue using S1P1/EDG1 antibody was performed. The section was pretreated using high-temperature and high-pressure mediated EDTA antigen retrieval buffer (pH 9.0), for 5 minutes. The tissues were incubated with primary antibody (HY-P84177, 1:50 dilution) at room temperature for 60 minutes. Detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. The tissues were counterstained with hematoxylin and mounted with neutral balsam mounting medium.
Immunohistochemical analysis of paraffin-embedded human Kidney cancer tissue using S1P1/EDG1 antibody was performed. The section was pretreated using high-temperature and high-pressure mediated EDTA antigen retrieval buffer (pH 9.0), for 5 minutes. The tissues were incubated with primary antibody (HY-P84177, 1:50 dilution) at room temperature for 60 minutes. Detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. The tissues were counterstained with hematoxylin and mounted with neutral balsam mounting medium.
Immunohistochemical analysis of paraffin-embedded human Gastric Cancer tissue using S1P1/EDG1 antibody was performed. The section was pretreated using high-temperature and high-pressure mediated EDTA antigen retrieval buffer (pH 9.0), for 5 minutes. The tissues were incubated with primary antibody (HY-P84177, 1:50 dilution) at room temperature for 60 minutes. Detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. The tissues were counterstained with hematoxylin and mounted with neutral balsam mounting medium.
Immunohistochemical analysis of paraffin-embedded human Prostate Cancer tissue using S1P1/EDG1 antibody was performed. The section was pretreated using high-temperature and high-pressure mediated EDTA antigen retrieval buffer (pH 9.0), for 5 minutes. The tissues were incubated with primary antibody (HY-P84177, 1:50 dilution) at room temperature for 60 minutes. Detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. The tissues were counterstained with hematoxylin and mounted with neutral balsam mounting medium.

背景

功能：鞘氨醇-1-磷酸 (S1P) 的 G 蛋白偶联受体，该受体似乎与异源 G 蛋白的 G (i) 亚类偶联。信号传导可激活 RAC1、SRC、PTK2/FAK1 和 MAP 激酶。在细胞迁移中发挥重要作用，可能通过其参与肌动蛋白细胞骨架的重组以及响应鞘氨醇激酶 SPHK1 活性增强的刺激而形成的伪足来实现。是细胞趋化性 (趋向鞘氨醇-1-磷酸) 所必需的。是正常胚胎心脏发育和正常心脏形态发生所必需的。在血管萌芽生成和血管成熟过程中发挥重要作用。抑制血管萌芽生成，以防止血管发育过程中过度萌芽。成熟 T 细胞从胸腺正常迁移至血液循环和外周淋巴器官所必需。参与破骨细胞前体细胞的迁移、骨矿化和骨稳态的调节 (基于相似性)。参与肺内皮细胞对氧化型 1-棕榈酰-2-花生四烯酰-sn-甘油-3-磷酸胆碱的反应，并参与预防呼吸机相关性肺损伤。

亚细胞定位：细胞膜；多通道膜蛋白；内体；膜筏

表达水平：
组织特异性：内皮细胞，以及在较小程度上，血管平滑肌细胞、成纤维细胞、黑素细胞和上皮样细胞。

诱导：在环己酰亚胺存在下，通过肿瘤促进剂佛波醇12-肉豆蔻酸酯13-乙酸酯 (PMA) 进行检测。

亚基：与 GNAI1 和 GNAI3 相互作用。与 CD69 相互作用；这种相互作用促进 S1PR1 降解 (PubMed:37039481)

中文名

S1P1/EDG1 抗体 (YA3874)

同用名

S1PR1; EDG1; S1P1; ECGF1; EDG-1; CHEDG1; D1S3362

文件资料

Select Batch:

Data Sheet (442 KB) SDS (251 KB)

COA (194 KB)

抗体使用指南 (1083 KB)

S1P1/EDG1 Antibody (YA3874) 相关分类

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

S1P1/EDG1 抗体 (YA3874)

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S1P1/EDG1 抗体 (YA3874)

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S1P1/EDG1 Antibody (YA3874) 相关分类

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