2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Reactive Oxygen Species (ROS) GABA Receptor
  4. Anticonvulsant agent 11

Anticonvulsant agent 11 (Compound 8b) 是一种抗惊厥剂。Anticonvulsant agent 11 通过提高细胞活力和降低 ROS 水平发挥神经保护作用。Anticonvulsant agent 11 可以诱导 GABAA α1 的表达，导致神经元超极化。Anticonvulsant agent 11 增加神经突细胞的数量和神经突的长度。Anticonvulsant agent 11 在小鼠中表现出剂量依赖性的抗惊厥作用。Anticonvulsant agent 11 可用于癫痫的研究。

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Anticonvulsant agent 11

Anticonvulsant agent 11 Chemical Structure

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Anticonvulsant agent 11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticonvulsant agent 11 (Compound 8b) is an anticonvulsant agent. Anticonvulsant agent 11 exerts neuroprotective effects by enhancing cell viability and reducing ROS levels. Anticonvulsant agent 11 induces the expression of GABAA α1, resulting in neuronal hyperpolarization. Anticonvulsant agent 11 increases the number of neurite-bearing cells and the length of neurites. Anticonvulsant agent 11 exhibits dose-dependent anticonvulsant effects in mice. Anticonvulsant agent 11 can be used for the research of epilepsy[1].

体外研究
(In Vitro)

Anticonvulsant agent 11 (1-40 μM; 24 h) 在浓度高达 20 μM 时不会对 SHSY-5Y 细胞产生显著的神经毒性，但在 40 μM 浓度下会导致细胞活力下降[1]。
Anticonvulsant agent 11 (1-50 μM; 24 h) 在浓度不超过 10 μM 时不会在 Neuro2a 细胞中诱导显著的神经毒性，但在 50 μM 浓度下会导致细胞活力下降[1]。
Anticonvulsant agent 11 (5-10 μM; 24 h) 可提高 Neuro2a 细胞中带有神经突的细胞比例及神经突长度，其中 10 μM 浓度下的效果相较于 NGF 处理具有显著性[1]。
Anticonvulsant agent 11 (1-10 μM; 24 h) 可通过提高细胞活力保护 SHSY-5Y 细胞免受 PTZ 诱导的神经毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticonvulsant agent 11 相关抗体:

Cell Viability Assay[1]

Cell Line: SHSY-5Y
Concentration: 1-10 μM
Incubation Time: 24 h
Result: Substantially increased cell viability in PTZ-exposed cells compared with PTZ alone-treated cells at 1, 5, and 10 μM.
Induced better cell viability (86.69%) compared to diazepam (75.79%).
体内研究
(In Vivo)

Compound 8b (1-4 mg/kg；腹腔注射；单次) 在戊四氮 (PTZ) 诱导的急性癫痫小鼠模型中呈现剂量依赖性抗惊厥作用，可显著延迟癫痫发作起始时间，缩短发作时长、降低发作频率与严重程度[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (either sex, 20-40 g, acute seizures induced by pentylenetetrazole)[1]
Dosage: 1 mg/kg; 2 mg/kg; 4 mg/kg
Administration: i.p.; single dose (30 minutes prior to seizure induction)
Result: Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group (1 mg/kg).
Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group (2 mg/kg).
Significantly delayed the latency of myoclonic and clonic seizures, reduced the duration of myoclonic and clonic seizures, reduced the number of jerks, and reduced seizure severity score compared to the PTZ-only group; efficacy was comparable to diazepam (4 mg/kg).
分子量

527.23

Formula

C25H15Cl4N5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticonvulsant agent 11 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticonvulsant agent 11Anticonvulsant agent11Anticonvulsant agent-11Reactive Oxygen Species (ROS)GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorPTZ-induced acute seizure mouse modelneuronal excitabilityGABAA α1 receptorGABAA receptor α1/γ2 interfaceepilepsySHSY-5Y cellsNeuro2a cellsneuronal cell lineschloride ionreactive oxygen speciesInhibitorinhibitorinhibit

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